ASIC1a antagonist-1

Cat. No.: HY-176550: Data Sheet
SDS
Handling Instructions
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ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC₅₀ of 27 nM (pH 6.7). ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research.

For research use only. We do not sell to patients.

ASIC1a antagonist-1 Chemical Structure

CAS No. : 1787243-08-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8 Na_v1.9

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

ASIC1a

27 nM (IC₅₀)

Molecular Weight

499.86

Formula

C₂₃H₂₉Cl₃N₄O₂

CAS No.

1787243-08-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1OC2=C(C=C1C(N)=N)C=CC(N(CCN(CC)CC)CC3=CC=C(C=C3)Cl)=C2.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (200.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0006 mL	10.0028 mL	20.0056 mL
5 mM	0.4001 mL	2.0006 mL	4.0011 mL
10 mM	0.2001 mL	1.0003 mL	2.0006 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (275 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Buta A, et al. Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction. J Med Chem. 2015 Jun 11;58(11):4449-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0006 mL	10.0028 mL	20.0056 mL	50.0140 mL
	5 mM	0.4001 mL	2.0006 mL	4.0011 mL	10.0028 mL
	10 mM	0.2001 mL	1.0003 mL	2.0006 mL	5.0014 mL
	15 mM	0.1334 mL	0.6669 mL	1.3337 mL	3.3343 mL
	20 mM	0.1000 mL	0.5001 mL	1.0003 mL	2.5007 mL
	25 mM	0.0800 mL	0.4001 mL	0.8002 mL	2.0006 mL
	30 mM	0.0667 mL	0.3334 mL	0.6669 mL	1.6671 mL
	40 mM	0.0500 mL	0.2501 mL	0.5001 mL	1.2504 mL
	50 mM	0.0400 mL	0.2001 mL	0.4001 mL	1.0003 mL
	60 mM	0.0333 mL	0.1667 mL	0.3334 mL	0.8336 mL
	80 mM	0.0250 mL	0.1250 mL	0.2501 mL	0.6252 mL
	100 mM	0.0200 mL	0.1000 mL	0.2001 mL	0.5001 mL