Fas(C-term) Antibody (YA5207)

Fas(C-term) Antibody (YA5207) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fas(C-term).

Fas, also known as CD95, serves as a receptor for TNFSF6/FASLG, initiating a cascade of apoptotic events crucial for programmed cell death. The adapter molecule FADD facilitates the recruitment of caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC) and initiating the cascade of caspases that mediate apoptosis. FAS-mediated apoptosis is implicated in peripheral tolerance induction and the antigen-stimulated suicide of mature T-cells. Additionally, secreted isoforms 2 to 6 of Fas have been identified, which function to block apoptosis in vitro. Fas engages in diverse protein interactions, including DAXX, HIPK3, RIPK1, FAIM2, BABAM2, FEM1B, FADD, NOL3, and CALM, forming a complex network that regulates cell death signaling. The interaction with various molecules highlights the multifaceted roles of Fas in cellular processes, emphasizing its significance in immune regulation and apoptosis modulation.

P25445

Observed band size: 45 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.