ACVR1 Antibody (YA4179)

ACVR1 Antibody (YA4179) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ACVR1. It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

Activin Receptor Type IA (ACVR1) is a bone morphogenetic protein (BMP) type I receptor involved in diverse biological processes including bone, heart, cartilage, nervous system and reproductive system development. Forming heterotetrameric complexes with type II receptors (AMHR2, ACVR2A or ACVR2B), it becomes transphosphorylated upon ligand (e.g., BMP7 or GDF2/BMP9) binding, subsequently phosphorylating SMAD1/5/8 to mediate BMP signaling (by similar: may activate non-canonical p38 MAPK pathways). ACVR1 also suppresses TGFβ/activin pathway signaling by competitively inhibiting activin binding to type II receptors (by similar: potentially promotes HAMP expression through BMP6 interaction).

Q04771

Predicted band size: 57 kDa; Observed band size: 57 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human ACVR1 (AA: 21-120) expressed in E. Coli.