PPM1A Antibody (YA3864)

Cat. No.: HY-P84167: Data Sheet User Guide for Antibodies
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PPM1A Antibody (YA3864) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PPM1A. It can be applicated for WB, FC, ELISA assays, in the background of human, monkey.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
Properties
Documentation

Description	PPM1A Antibody (YA3864) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PPM1A. It can be applicated for WB, FC, ELISA assays, in the background of human, monkey.
Background	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) is an enzyme characterized by its broad specificity. It functions as a negative regulator of TGF-beta signaling by dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4 and subsequent nuclear export. This enzymatic activity ultimately terminates the TGF-beta-mediated signaling pathway. Additionally, PPM1A dephosphorylates PRKAA1 and PRKAA2, contributing to the regulation of cellular processes associated with AMP-activated protein kinase. Furthermore, PPM1A plays a crucial role in the termination of TNF-alpha-mediated NF-kappa-B activation by dephosphorylating and inactivating IKBKB/IKKB. The diverse substrate specificity of PPM1A underscores its importance in modulating key signaling pathways, highlighting its regulatory functions in cellular responses to TGF-beta and TNF-alpha signaling (
Gene ID	5494 [NCBI]
SwissProt ID	P20265
Synonyms	PP2CA; PP2Calpha; PP2C-ALPHA
Molecular Weight	Predicted band size: 42 kDa; Observed band size: 42 kDa
Purity	affinity purified.
Conjugation	Non-conjugated
Product Categories	Primary Antibody; Mouse Monoclonal Antibody
Host	Mouse
Reactivity	Human, Monkey
Dilution Ratio	WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000
Application	WB, FC, ELISA
Appearance	Liquid
Formulation	Supplied in PBS with 0.05% sodium azide
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG1
Immunogen	Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.
Documentation	Data Sheet (234 KB) User Guide for Antibodies (1077 KB)

PPM1A Antibody (YA3864) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PPM1A Antibody (YA3864)

Biological Activity

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PPM1A Antibody (YA3864) Related Classifications

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