Torsin 1A Antibody (YA2935)

Torsin 1A Antibody (YA2935) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2935), targeting Torsin 1A, with a predicted molecular weight of 38 kDa (observed band size: 35 kDa). Torsin 1A Antibody (YA2935) can be used for WB, FC experiment in human background.

Torsin 1A is a protein with chaperone functions crucial for regulating protein folding, processing, stability, and localization, as well as reducing misfolded protein aggregates. It collaborates with the COP9 signalosome complex (CSN) to regulate synaptic vesicle recycling and control STON2 protein stability. In the nucleus, Torsin 1A may link the cytoskeleton to the nuclear envelope, a mechanism essential for nuclear polarity, cell movement, and neuronal nuclear envelope integrity. Additionally, it participates in cellular trafficking and may modulate dopamine neurotransmission by influencing the subcellular localization of multipass membrane proteins like the dopamine transporter SLC6A3. Within the endoplasmic reticulum, Torsin 1A contributes to protein folding quality control by enhancing the clearance of misfolded proteins (e.g., SGCE variants) or maintaining them in an intermediate state for proper refolding. In non-neural tissues, it may exhibit redundant functions with TOR1B.

O14656

Predicted band size: 38 kDa; Observed band size: 35 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;FC: 1/50-1/100

WB, FC

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Torsin A