Fas Ligand Antibody (YA4042)

Fas Ligand Antibody (YA4042) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD178. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

CD178 is a cytokine that binds to the TNFRSF6/FAS receptor, transmitting apoptotic signals into cells. It is involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis, and T-cell development. CD178 initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells, contributing to the termination of immune responses (by similar). TNFRSF6/FAS-mediated apoptosis also plays a role in peripheral tolerance induction (by similar). Additionally, CD178 binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. It induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (by similar). While CD178 can induce apoptosis, it does not appear to be essential for this process. Its cytoplasmic form also inhibits gene transcription.

P48023

Predicted band size: 31 kDa; Observed band size: 31 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IF: 1/50-1/200; FC: 1/200-1/400; ELISA: 1/10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CD178 (AA: extra 103-281) expressed in E. Coli.