CD11b Antibody (YA3751)

CD11b Antibody (YA3751) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ITGAM. It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

CD11b, also known as integrin ITGAM/ITGB2, is involved in various adhesive interactions of monocytes, macrophages, and granulocytes, as well as mediating the uptake of complement-coated particles and pathogens. It is identical to CR-3, the receptor for the iC3b fragment of the third complement component, and likely recognizes the R-G-D peptide in C3b. Additionally, CD11b serves as a receptor for fibrinogen, factor X, and ICAM1, recognizing the P1 and P2 peptides of the fibrinogen gamma chain. It regulates neutrophil migration and, in association with the beta subunit ITGB2/CD18, is required for CD177-PRTN3-mediated activation of TNF-primed neutrophils. By similarity, CD11b may regulate phagocytosis-induced apoptosis in extravasated neutrophils and play a role in mast cell development. By similarity, it is also required with TYROBP/DAP12 in microglia to control the production of superoxide ions, promoting neuronal apoptosis during brain development.

P11215

Predicted band size: 127 kDa; Observed band size: 127 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.