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Phe

" in MedChemExpress (MCE) Product Catalog:

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2415

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

2639

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0249A

Phe-Met-Arg-Phe amide trifluoroacetate	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K ⁺ current, with ED₅₀ of 23 nM in the peptidergic caudodorsal neurons.

HY-P4678

*(Phe2,Orn8)-Oxytocin*	Vasopressin Receptor	Neurological Disease
(Phe2,Orn8)-Oxytocin is a selective V1 vasopressin agonist. (Phe2,Orn8)-Oxytocin induces a sustained contractility of rabbit epididymis with EC₅₀ value of 280 nM .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-P4680

*(Phe13,Tyr19)-MCH (human, mouse, rat)*	MCHR1 (GPR24)	Neurological Disease
(Phe13,Tyr19)-MCH (human, mouse, rat) is a potent SLC-1 and S643b receptor ligand. (Phe13,Tyr19)-MCH (human, mouse, rat) can be used as an agonist for SLC-1 and S643b receptor .

HY-W141936

Phe-Gly	Amino Acid Derivatives	Others
Phe-Gly hydrate is a Glycine (HY-Y0966) derivative .

HY-P0249

Phe-Met-Arg-Phe, amide	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe, amide dose dependently (ED₅₀=23 nM) activates a K ⁺ current in the peptidergic caudodorsal neurons.

HY-P0249B

Phe-Met-Arg-Phe, amide acetate	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe, amide acetate dose dependently (ED₅₀=23 nM) activates a K ⁺ current in the peptidergic caudodorsal neurons .

HY-P4678A

*(Phe2,Orn8)-Oxytocin acetate*	Vasopressin Receptor	Neurological Disease
(Phe2,Orn8)-Oxytocin acetate is a selective V1 vasopressin agonist. (Phe2,Orn8)-Oxytocin acetate induces a sustained contractility of rabbit epididymis with EC₅₀ value of 280 nM .

HY-P4565

Phe-Arg-Arg-Gly	Cathepsin	Others
Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling .

HY-P4681

*(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)*	Melanocortin Receptor	Metabolic Disease
(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) is a fragment of the ACTH hormone. (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) can be labeled with I125 on Tyr23 to produce a radiolabeled ligand .

HY-W092109

*H-Phe-Trp-OH* Phenylalanyltryptophan	Endogenous Metabolite	Neurological Disease Cancer
H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite. H-Phe-Trp-OH can be used in the research of hepatocellular carcinoma and tic disorders .

HY-129362

Phe-Lys(Fmoc)-PAB	ADC Linker	Cancer
Phe-Lys(Fmoc)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-129349

Phe-Lys(Trt)-PAB	ADC Linker	Cancer
Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-W009602

Phenylalanylalanine Phe-ala	Neprilysin	Others
Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism .

HY-W009602R

Phenylalanylalanine (Standard)	Neprilysin	Others
Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism .

HY-101444A

PAβN dihydrochloride 10+ Cited Publications MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride	Bacterial	Infection
PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.

HY-P10034

Pheromonotropin (pseudaletia separata) Pss-PT	Endogenous Metabolite	Endocrinology
Pheromonotropin (Pseudaletia separata) (Pss-PT) is an armyworm (Pseudaletia separata) pheromone with the C-terminal pentapeptide FXPRL-amide. Pheromonotropin (Pseudaletia separata) belongs to the PK/PBAN family and stimulates sex pheromone biosynthesis in moths, mediating feeding (intestinal muscle contraction), development (embryonic diapause, pupal diapause, and pupation), and defense against natural enemy insects wait .

HY-P4683A

(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate	Vasopressin Receptor	Cardiovascular Disease
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats .

HY-P4683

(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin	Vasopressin Receptor	Cardiovascular Disease
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats .

HY-W006069

*H-Phe(3,5-DiF)-OH*	Protease Activated Receptor (PAR)	Others
H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction .

HY-P4556

*H-Phe-Gly-His-p-nitro-Phe-Phe-Ala-Phe-OMe*	Biochemical Assay Reagents	Others
H-Phe-Gly-His-p-nitro-Phe-Phe-Ala-Phe-OMe is a polypeptide that can be hydrolyzed by Rennin (HY-P2810). H-Phe-Gly-His-p-nitro-Phe-Phe-Ala-Phe-OMe is commonly used as a biochemical reaction reagent .

HY-P4524

FA-Phe-Phe	Angiotensin-converting Enzyme (ACE)	Others
FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A .

HY-P3318

Boc-Phe-Leu-Phe-Leu-Phe L-BOC2	Leukotriene Receptor	Inflammation/Immunology
Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology .

HY-P4306

*Z-Phe-Phe-Diazomethylketone*	Cathepsin	Inflammation/Immunology
Z-Phe-Phe-Diazomethylketone is a selective inhibitor of cathepsin L .

HY-P4364

*Suc-Phe-Leu-Phe-4MβNA*	Biochemical Assay Reagents	Others
Suc-Phe-Leu-Phe-4MβNA is a fluorescent peptide substrate .

HY-P2355

BOC-FlFlF BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (K_D) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation .

HY-P2355A

BOC-FlFlF TFA BOC2 TFA; Boc-Phe-dLeu-Phe-dLeu-Phe TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
BOC-FlFlF (TFA) (Boc-Phe-dLeu-Phe-dLeu-Phe (TFA)) is a selective FPR1 antagonist. BOC-FlFlF has an apparent dissociation constant (K_D) of 230 nM as determined by the intracellular calcium mobilization assay. BOC-FlFlF can be used for the study of inflammation .

HY-W007970

*H-Phe-Phe-OH*	Endogenous Metabolite	Neurological Disease
H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine.

HY-P4561

*H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH*	Cathepsin	Others
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis .

HY-115733

Cathepsin L-IN-2 1 Publications Verification (Rac)-Z-Phe-Phe-FMK	Cathepsin	Cancer
Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC₅₀ of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.

HY-P4270

*Met-Arg-Phe-Ala*	Neprilysin	Neurological Disease
Met-Arg-Phe-Ala is a peptide. Met-Arg-Phe-Ala also is a potent competitive inhibitor for enkephalin-generating endopeptidase (EGE). Met-Arg-Phe-Ala can be used for the research of neurological disease .

HY-P10095

*D-Val-Phe-Lys-CMK* D-Val-Phe-Lys Chloromethyl ketone	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) can inhibit plasmin activity .

HY-137164A

*Ala-Ala-Phe-AMC TFA*	Fluorescent Dye	Others
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .

HY-P4464

*Ala-Phe-Pro-pNA*	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .

HY-P10095A

*D-Val-Phe-Lys-CMK diTFA* D-Val-Phe-Lys Chloromethyl ketone diTFA	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) diTFA can inhibit plasmin activity .

HY-P4554

*H-Phe-Arg-OH*	Endogenous Metabolite	Metabolic Disease
H-Phe-Arg-OH is a dipeptide containing phenylalanine and arginine. H-Phe-Arg-OH can be separated from Bradykinin (HY-P0206) through Angiotensin-converting enzyme (ACE, HY-P2983). H-Phe-Arg-OH can be used for metabolic research .

HY-P4641

*H-Trp-Phe-OH*	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice .

HY-P4334

Bz-RGFFL-4MβNA Bz-Arg-Gly-Phe-Phe-Leu-4MβNA	Fluorescent Dye	Others
Bz-RGFFL-4MβNA (Bz-Arg-Gly-Phe-Phe-Leu-4MβNA) is a peptide and can be used fluorogenic substrate .

HY-P4464A

*Ala-Phe-Pro-pNA TFA*	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .

HY-P4295

*Z-Phe-Ala-diazomethylketone* PADK	Cathepsin γ-secretase	Neurological Disease
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research .

HY-P4579

*Pyr-Phe-OH*	Biochemical Assay Reagents	Others
Pyr-Phe-OH is an effective pyrene-based hydrogel. Pyr Phe OH can self-assemble into hydrogels in the range of pH=7.5-14.0, and also shows a very low gel concentration (0.037% (w/v)) in phosphate buffer .

HY-P4360

*Suc-Ala-Phe-Lys-AMC*	Fluorescent Dye	Others
Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K .

HY-P2376

*Arg-Phe-Asp-Ser*	ADC Linker	Cancer
Arg-Phe-Asp-Ser is a cleavable ADC linker.

HY-P4515

*Z-Phe-Arg-pNA*	Cathepsin	Others
Z-Phe-Arg-pNA is a substrate of Cathepsin L .

HY-P4582

*Suc-Phe-Ala-Ala-Phe-pNA* Suc-FAAF-pNA	Ser/Thr Protease	Others
Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a synthetic polypeptide that can serve as a substrate for the protease from Aeribacillus pallidus VP3 (SPVP), the serine alkaline protease from Caldicoprobacter guelmensis (SAPCG) strain D2C22 ^T, the alcalase ultra 2.5 L and the thermolsyin type X .

HY-79131S5

*Fmoc-Phe-OH-13C*	Isotope-Labeled Compounds	Others
Fmoc-Phe-OH- ¹³C is the ¹³C labeled Fmoc-Phe-OH . Fmoc-Phe-OH is a phenylalanine derivative .

HY-114437

Fusion Inhibitory Peptide Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication Inhibitory Peptide	Influenza Virus	Infection
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein .

HY-P4196

Met-Enkephalin-Arg-Phe	Opioid Receptor	Neurological Disease
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity .

HY-103292

*[Phe8Ψ(CH-NH)Arg9]-Bradykinin*	Bradykinin Receptor	Cardiovascular Disease
[Phe8Ψ(CH-NH)Arg9]-Bradykinin is a selective Bradykinin receptor B₂ agonist (not cleaved by protein kinase I/II). [Phe8Ψ(CH-NH)Arg9]-Bradykinin has potential for the research of hypertension .

HY-P3962

*[Phe2]-TRH*	Thyroid Hormone Receptor	Endocrinology
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin .

Cat. No.	Product Name	Type

HY-P4202

*Suc-Ala-Glu-Pro-Phe-pNA* Suc-AEPF-pNA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-W010991

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

FAPGG

Chromogenic Substrates Amino acids and Derivatives

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 ^-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .

HY-164762

Trastuzumab rezetecan SHR-A1811	Chromogenic Assays
Trastuzumab rezetecan (SHR-A1811) is a HER2-targeting antibody-drug conjugate (ADC). Trastuzumab rezetecan is composed of a humanized anti-HER2 antibody (HY-P9907), a cleavable linker MC-Gly-Gly-Phe-Gly (HY-44246), and a topoisomerase I inhibitor payload Rezetecán (HY-147408). Trastuzumab rezetecan can be used for research in HER2-positive breast cancer .

HY-P1363F3

5-FAM-β-Amyloid (1-42), human Tris 5-FAM-Amyloid β-peptide (1-42) (human) Tris	Fluorescent Dyes/Probes
5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) TFA is a5-FAM labeled β-Amyloid (1-42), human TFA (HY-P1363).

HY-D1532

*DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS*	Fluorescent Dyes/Probes
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .

HY-D1503

*Glut-Phe-AMC*	Fluorescent Dyes/Probes
Glut-Phe-AMC is a fluorescent dye.

HY-131833G

*Fmoc-Gly-Gly-Phe-OH (GMP)*	Fluorescent Dye
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-P4202A

*Suc-Ala-Glu-Pro-Phe-pNA TFA* Suc-AEPF-pNA TFA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-131990G

*MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)*	Fluorescent Dye
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-45672G

*Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)*	Fluorescent Dye
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

Cat. No.	Product Name	Type

HY-P5282

ApoA-I mimetic peptide	Drug Delivery
ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) is an ApoA-I mimetic peptide. ApoA-I mimetic peptide has good phosphatidylcholine: cholesterol acyltransferase (LCAT) activation activity. ApoA-I mimetic peptide can be used to synthesize peptide/lipid complexes. ApoA-I mimetic peptide can be used in atherosclerosis research.

HY-131833G

*Fmoc-Gly-Gly-Phe-OH (GMP)*	Biochemical Assay Reagents
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-137164

*Ala-Ala-Phe-AMC*	Biochemical Assay Reagents
Ala-Ala-Phe-AMC serves as a fluorogenic substrate that exhibits positively charged properties, making it suitable for assessing proteolytic activity.

HY-P1759A

*N-CBZ-Phe-Arg-AMC hydrochloride* Z-FR-AMC hydrochloride	Cell Assay Reagents
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a tissue protease substrate that can be used to assess the activity of lysosomal tissue proteases .

HY-131990G

*MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)*	Biochemical Assay Reagents
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-45672G

*Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)*	Biochemical Assay Reagents
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

HY-142994

Wybutosine	Drug Delivery
Wybutosine is a modified base adjacent to the anticodon of tRNA(Phe) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1904

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa	Natural Products Animals Source classification	Others
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues .

HY-W092109

*H-Phe-Trp-OH* Phenylalanyltryptophan	Natural Products Animals Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite. H-Phe-Trp-OH can be used in the research of hepatocellular carcinoma and tic disorders .

HY-W009602

Phenylalanylalanine Phe-ala	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Neprilysin
Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism .

HY-W007970

*H-Phe-Phe-OH*	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine.

HY-W009602R

Phenylalanylalanine (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Neprilysin
Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism .

HY-P4196

Met-Enkephalin-Arg-Phe	Monophenols Source classification Phenols Endogenous metabolite	Opioid Receptor
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity .

HY-W092109R

*H-Phe-Trp-OH (Standard)*	Natural Products Animals Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
H-Phe-Trp-OH (Standard) is an analytical standard of H-Phe-Trp-OH (HY-W092109). This product is intended for research and analytical applications. H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite. H-Phe-Trp-OH can be used in the research of hepatocellular carcinoma and tic disorders .

HY-N13450

*Cyclo(Phe-Hpro)*	Alkaloids Piperidine Alkaloids Rubia schumanniana E. Pritz. Source classification Rubiaceae Plants	Others
Cyclo(Phe-Hpro) is a natural product .

HY-N13432

*Cyclo(Ala-Phe)*	Natural Products Rubia schumanniana E. Pritz. Source classification Rubiaceae Plants	Others
Cyclo(Ala-Phe) is a natural product .

HY-N13459

*Cyclo(Phe-Leu)*	Alkaloids Rubia schumanniana E. Pritz. Other Alkaloids Source classification Rubiaceae Plants	Others
Cyclo(Phe-Leu) is a natural product .

HY-N13465

*Cyclo(Tyr-Phe)*	Alkaloids Animals Other Alkaloids Source classification	Others
Cyclo(Tyr-Phe) is a natural product .

HY-101399

γ-Glu-Phe γ-GlutamylPhenylalanine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-P1934A

*Cyclo(L-Phe-L-Pro)*	Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Cancer	Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-101399A

*γ-Glu-Phe* TFA** γ-GlutamylPhenylalanine TFA	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-W295873

*Cyclo(Phe-Gly)* 1 Publications Verification	Infection Natural Products Classification of Application Fields Source classification Plants Compositae Disease Research Fields Gueldenstaedtia verna (Georgi) Boriss. Cancer	Bacterial
Cyclo(Phe-Gly) is a cyclodipeptides with antimicrobial and anticancer activities, isolated from broth culture of endophytic Streptomyces YIM 64018 associated with Paraboea sinensis .

HY-P1934AR

*Cyclo(L-Phe-L-Pro) (Standard)*	Natural Products Microorganisms Source classification	Reference Standards Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)
Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-N12513

*Cyclo(L-Phe-trans-4-OH-L-Pro)*	Natural Products Microorganisms Source classification	Fungal
Cyclo(L-Phe-trans-4-OH-L-Pro) is an antifungal peptides .

HY-107378

L-Valyl-L-phenylalanine ValylPhenylalanine; H-VAL-Phe-OH	Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

HY-N3655

*Cyclo(D-Phe-L-Pro)* NSC 255998	Alkaloids Microorganisms Other Alkaloids Source classification	Others
Cyclo(D-Phe-L-Pro) (NSC 255998) is a flavonoid product that can be isolated from Rhododendron mucronulatum .

HY-W141810

4-Amino-L-phenylalanine hydrochloride H-Phe(4-NH2)-OH hydrochloride	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Amino-L-phenylalanine (H-Phe(4-NH2)-OH) hydrochloride is an endogenous metabolite.

HY-N2355

Solasurine	Alkaloids Piperidine Alkaloids Classification of Application Fields Solanum surattense Burm. F. Source classification Other Diseases Plants Solanaceae Disease Research Fields	SARS-CoV
Solasurine is a steroidal alkaloid that can be isolated from Solanum surrattence. Solasurine can interact with the C3-like protease (SARS-CoV-2 main protease) amino acids Phe8, Pro9, Ile152, Tyr154, Pro293, Phe294, Val297, and Arg298 .

HY-150012

N-Lactoyl-Phenylalanine 4 Publications Verification Lac-Phe	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-Phenylalanine can reduce obesity and improve glucose tolerance .

HY-107378R

L-Valyl-L-phenylalanine (Standard)	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
L-Valyl-L-phenylalanine (Standard) is the analytical standard of L-Valyl-L-phenylalanine. This product is intended for research and analytical applications. L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

HY-N12513R

*Cyclo(L-Phe-trans-4-OH-L-Pro) (Standard)*	Natural Products Microorganisms Source classification	Reference Standards Fungal
5α-Cholestan-3β-ol (Standard) is the analytical standard of 5α-Cholestan-3β-ol. This product is intended for research and analytical applications. 5α-Cholestan-3β-ol is a derivitized steroid compound.

HY-W012161

Alanylphenylalanine L-Alanyl-L-Phenylalanine; H-Ala-Phe-OH	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Alanylphenylalanine is a potential antitumor agent that targets DNA via metal coordination. The complex of Alanylphenylalanine and Au (III) can bind to DNA and inhibit tumor cell proliferation[1][2].

HY-101399R

*γ-Glu-Phe* (Standard)** γ-GlutamylPhenylalanine (Standard)	Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-P2358

PSMα3	Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR)
PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) .

HY-P3065

Calcicludine	Natural Products Animals Source classification	Calcium Channel
Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel .

HY-P0017

Aprotinin 25+ Cited Publications	Cardiovascular Disease Natural Products Animals Source classification Disease Research Fields	Influenza Virus Ser/Thr Protease
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with K_is of 0.06 pM and 9 nM, respectively.

HY-105088A

Pexiganan acetate MSI 78	Natural Products Animals Source classification	Bacterial
Pexiganan acetate (MSI 78) is the acetate salt form of Pexiganan (HY-105088). Pexiganan acetate is an orally active broad-spectrum antimicrobial peptide, which inhibits 99% gram-positive and Gram-negative aerobic bacteria through disruption of cell membrane/cells permeability. Pexiganan acetate can be used in the research of infections, such as diabetic foot ulcer infections .

HY-P0269

Magainin 1 Magainin I	Infection Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial Fungal Antibiotic
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-P0269A

Magainin 1 TFA Magainin I TFA	Infection Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial Fungal Antibiotic
Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-P0270

Magainin 2 Magainin II	Infection Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial Antibiotic Fungal
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-P5689

Maximin 42	Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Maximin 42 is an antimicrobial peptide. Maximin 42 has antibacterial activity against S. aureus (MIC: 37.5 μg/mL). Maximin 42 has hemolytic activities against human red cells .

HY-106302

Duramycin Moli1901; Lancovutide	Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Bacterial
Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) .

HY-P5714

Abaecin	Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Abaecin is an antibacterial response peptide. Abaecin shows specific activity against an Apidaecin-resistant Xanthomonas strain .

HY-P5719

Andropin	Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Andropin is a male-specific antibacterial peptide that can be found in Drosophila melanogaster .

HY-P3055

Dendrotoxin-I DTX-I	Animals Cyclopeptides Source classification Animal Venoms	Potassium Channel
Dendrotoxin-I (DTX-I) is a potent K ⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .

HY-P0260

p2Ca	Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Others
p2Ca, an 8-mer peptide, is a ligand that is naturally processed and presented to the Ld-alloreactive T cell clone, 2C.

HY-N13127

Segetalin C	Natural Products Source classification Plants Vaccaria hispanica Caryophyllaceae	Others
Segetalin C is a cyclic peptide that increases uterine weight in ovariectomized rats (2.5 mg/kg).

HY-P6294

Pseudostellarin G	Natural Products Pseudostellaria heterophylla (Miq.) Pax Source classification Plants Caryophyllaceae	Tyrosinase
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-P0206

Bradykinin 10+ Cited Publications	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P0303

Crustacean cardioactive peptide，free acid	Cardiovascular Disease Natural Products Animals Neurological Disease Classification of Application Fields Source classification Disease Research Fields	G Protein-coupled Receptor Kinase (GRK)
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.

HY-P0201

Substance P 20+ Cited Publications Neurokinin P	Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Neurokinin Receptor Endogenous Metabolite
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P5664

Maximin S4	Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Maximin S4 is an antimicrobial peptide derived from toad Bombina maxima. Maximin S4 has antibacterial activity against mycoplasma .

HY-P0259

Xenin	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.

HY-P5672

Maximin 39	Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .

HY-P1866A

β-Endorphin, equine TFA	Natural Products Source classification Endogenous metabolite	Opioid Receptor
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. β-Endorphin, equine TFA has analgesic properties .

HY-P1866

β-Endorphin, equine	Natural Products Source classification Endogenous metabolite	Opioid Receptor
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors . Analgesic properties .

HY-P1841

Glucagon-Like Peptide (GLP) II, human	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes .

Species:	Human (3)
Tag:	His (2) Myc (1) GST (2)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P704073

	PDHA1 Protein, Human (GST) Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; PDHA1; Phe1A	Human	E. coli
	The PDHA1 protein is an important component of the pyruvate dehydrogenase complex and is responsible for coordinating the conversion of pyruvate to acetyl-CoA and CO2. It establishes an important link between glycolysis and the tricarboxylic acid (TCA) cycle, ensuring seamless integration of metabolic pathways. PDHA1 Protein, Human (GST) is the recombinant human-derived PDHA1 protein, expressed by E. coli, with N-GST labeled tag.

HY-P704071

	PDHA1 Protein, Human (His, GST) Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; PDHA1; Phe1A	Human	E. coli
	The PDHA1 protein is an important component of the pyruvate dehydrogenase complex and is responsible for coordinating the conversion of pyruvate to acetyl-CoA and CO2. It establishes an important link between glycolysis and the tricarboxylic acid (TCA) cycle, ensuring seamless integration of metabolic pathways. PDHA1 Protein, Human (His, GST) is the recombinant human-derived PDHA1 protein, expressed by E. coli, with C-6*His and N-GST labeled tag.

HY-P704072

	PDHA1 Protein, Human (His, Myc) Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; PDHA1; Phe1A	Human	E. coli
	The PDHA1 protein is an important component of the pyruvate dehydrogenase complex and is responsible for coordinating the conversion of pyruvate to acetyl-CoA and CO2. It establishes an important link between glycolysis and the tricarboxylic acid (TCA) cycle, ensuring seamless integration of metabolic pathways. PDHA1 Protein, Human (His, Myc) is the recombinant human-derived PDHA1 protein, expressed by E. coli, with C-Myc and N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-79131S5

*Fmoc-Phe-OH-13C*
Fmoc-Phe-OH- ¹³C is the ¹³C labeled Fmoc-Phe-OH . Fmoc-Phe-OH is a phenylalanine derivative .

HY-79131S2

*Fmoc-Phe-OH-d5*
Fmoc-Phe-OH-d₅ is the deuterium labeled Fmoc-Phe-OH .

HY-79131S1

*Fmoc-Phe-OH-13C9,15N*
Fmoc-Phe-OH- ¹³C₉, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .

HY-159191S

*VQPGQN(Phe-13C9,15N)HMFTKEKLEEVIKDI TFA*
VQPGQN(Phe- ¹³C9, ¹⁵N)HMFTKEKLEEVIKDI (TFA) is the ¹³C and ¹⁵N labeled isotope of VQPGQN-HMFTKEKLEEVIKDI (TFA) .

HY-79131S3

*Fmoc-Phe-OH-15N*
Fmoc-Phe-OH- ¹⁵N is a ¹⁵N-labeled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .

HY-W738325

*H-Phe-OMe.hydrochloride-d5*
H-Phe-OMe.hydrochloride-d₅ is the deuterium labeled H-Phe-OMe.hydrochloride (HY-Y1394). H-Phe-OMe.hydrochloride is a phenylalanine derivative .

HY-79131S4

*Fmoc-Phe-OH-d8*
Fmoc-Phe-OH-d₈ is the deuterium labeled Fmoc-Phe-OH.

HY-79131S

*Fmoc-Phe-OH-13C6*
Fmoc-Phe-OH- ¹³C₆ is a ¹³C-labeled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .

HY-W011026S1

*Fmoc-D-Phe-OH-d8*
Fmoc-D-Phe-OH-d₈ is the deuterium labeled Fmoc-D-Phe-OH.

HY-W011026S

*Fmoc-D-Phe-OH-d5*
Fmoc-D-Phe-OH-d₅ is the deuterium labeled Fmoc-D-Phe-OH.

HY-131990S

*MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d5*
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d₅ is deuterated labeled MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH .

HY-101399S

*γ-Glu-(Phe-13C9,15N)*
γ-Glu-(Phe- ¹³C9, ¹⁵N) is the ¹³C and ¹⁵N labeled isotope of γ-Glu-Phe(HY-101399).γ-Glu-Phe or the postenzymatic reaction mixture enhanced the umami intensity of commercial soy sauce and model chicken soup.

HY-101399SA

*γ-Glu-(Phe-13C9,15N) TFA*
γ-Glu-(Phe-13C9,15N) (γ-Glutamylphenylalanine-13C9,15N) TFA is the ¹³C- and ¹⁵N-labeled γ-Glu-Phe TFA (HY-101399A). γ-Glu-Phe TFA is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-150012S1

N-Lactoyl-Phenylalanine-13C6
N-Lactoyl-Phenylalanine- ¹³C₆ (Lac-Phe- ¹³C₆) is ¹³C labeled N-Lactoyl-Phenylalanine. N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-Phenylalanine can reduce obesity and improve glucose tolerance .

HY-15448S1

Tezacaftor-d6

Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-W585934S

Fructose-phenylalanine-13C6
Fructose-phenylalanine- ¹³C₆ is ¹³C labeled Fructose-phenylalanine.

HY-176178S

LFVFAVCFSCWV(Leu-13C6,15N)PQGQYGR
LFVFAVCFSCWV(Leu- ¹³C₆, ¹⁵N)PQGQYGR is the ¹³C- and ¹⁵N-labeled LFVFAVCFSCWVPQGQYGR.

HY-P0265AS

β-Amyloid-15N (1-40) TFA
β-Amyloid- ¹⁵N (1-40) (TFA) is the ¹⁵N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease .

HY-P1363S

β-Amyloid-15N (1-42), human TFA
β-Amyloid- ¹⁵N (1-42), human (TFA) is the ¹⁵N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .

HY-P1363S1

β-Amyloid (1-42), human, Ala(13C3,15N) TFA

β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 ℃, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 ℃ to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P0206S1

RPP-(Gly-13C2,15N)-FSPFR TFA
RPP-(Gly-1 ¹³C₂, ¹⁵N)-FSPFR TFA is ¹³C- and ¹⁵N-labeled Bradykinin (HY-P0206). Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P0206S

RPPGFSPF-(Arg-13C6,15N) TFA
RPPGFSPF-(Arg- ¹³C₆, ¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled RPPGFSPF.

HY-176179S

LFFAADHLV(Val-13C5,15N)CE
LFFAADHLV(Val- ¹³C₅, ¹⁵N)CE is the ¹³C- and ¹⁵N-labeled LFFAADHLVCE.

HY-156345S1

LPFTFGQGTK-(Lys-13C6,15N2) (TFA)
LPFTFGQGTK-(Lys- ¹³C₆, ¹⁵N₂) TFA is the peptide containing ¹³C- and ¹⁵N-labeled Lys.

HY-163426S

AFFGHYLYEVAR-(Arg-13C6,15N4)
AFFGHYLYEVAR-(Arg- ¹³C₆, ¹⁵N₄) is ¹³C and ¹⁵N labeled AFFGHYLYEVAR-(Arg) .

HY-176277S

Fibrinopeptide B, human-(Val-13C5,15N, Arg-13C6,15N4) TFA
Fibrinopeptide B, human-(Val- ¹³C₅, ¹⁵N, Arg- ¹³C₆, ¹⁵₄) TFA is the ¹³C- and ¹⁵N-labeled Fibrinopeptide B, human (HY-P1493). Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin .

HY-163427S

FNLEALVTHTLPFEK-(Lys-13C6,15N2)
FNLEALVTHTLPFEK-(Lys- ¹³C₆, ¹⁵N₂) is ¹³C and ¹⁵N labeled FNLEALVTHTLPFEK-(Lys) .

HY-176177S

DEKM(Leu-13C6,15N)VLWVVALSGISTLFFAA
DEKM(Leu- ¹³C₆, ¹⁵N)VLWVVALSGISTLFFAA is the ¹³C- and ¹⁵N-labeled DEKMVLWVVALSGISTLFFAA.

HY-P2625S

GLP-2(3-33) (Leu-13C6,15N)
GLP-2(3-33) (Leu- ¹³C₆, ¹⁵N) is ¹³C and ¹⁵N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM).

HY-P2625S1

GLP-2(3-33) (Leu-13C6,15N) TFA
GLP-2(3-33) (Leu- ¹³C₆, ¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM).

HY-P1142S

GLP-2(rat) (Ala-13C3,15N)
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

HY-P1142S1

GLP-2(rat) (Ala-13C3,15N) TFA
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

HY-P0014AS

Liraglutide-d8 tetraTFA
Liraglutide-d₈ tetraTFA is deuterium labeled Liraglutide (HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-P0014S2

Liraglutide-13C6,15N TFA
Liraglutide- ¹³C₆, ¹⁵N (TFA)is the ¹³C and ¹⁵N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .

HY-P0014S1

Liraglutide-13C5,15N TFA
Liraglutide- ¹³C₅, ¹⁵N (tetraTFA) is the ¹³C and ¹⁵N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .

HY-114118S3

Semaglutide-13C6,15N TFA

Semaglutide- ¹³C₆, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Semaglutide TFA (HY-114118A). Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-13443S

Exendin-4 (Leu-13C6,15N) TFA
Exendin-4 (Leu- ¹³C₆, ¹⁵N) (Exenatide (Leu- ¹³C₆, ¹⁵N)) TFA is the ¹³C- and ¹⁵N-labeled Exendin-4 TFA (HY-13443). Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM .

HY-P0058S

Pramlintide-(Ala-13C3,15N)
Pramlintide-(Ala- ¹³C₃, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Pramlintide. Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-P0119S

Lixisenatide (Leu-13C6,15N) TFA

Lixisenatide (Leu- ¹³C₆, ¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled Lixisenatide (HY-P0119). Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis .

HY-173106S

YTASD(Leu-13C6,15N)FR TFA
YTASD(Leu- ¹³C₆, ¹⁵N)FR TFA is the ¹³C- and ¹⁵N-labeled YTASD(Leu)FR TFA.

HY-173103S

FYDPL(Ala-13C3,15N)GK TFA
FYDPL(Ala- ¹³C₃, ¹⁵N)GK TFA is the ¹³C- and ¹⁵N-labeled FYDPL(Ala)GK TFA.

HY-173100S

GIFP(Leu-13C6,15N)AER TFA
GIFP(Leu- ¹³C₆, ¹⁵N)AER TFA is the ¹³C- and ¹⁵N-labeled GIFP(Leu)AER TFA.

HY-173101S

GHFP(Leu-13C6,15N)AER TFA
GHFP(Leu- ¹³C₆, ¹⁵N)AER TFA is the ¹³C- and ¹⁵N-labeled GHFP(Leu)AER TFA.

HY-163424S

SSVFVADPK-(Lys-13C6,15N2)
SSVFVADPK-(Lys- ¹³C₆, ¹⁵N₂) is ¹³C and ¹⁵N labeled SSVFVADPK-(Lys).

HY-P3207S

DLPLTFGGGT-Lys-13C6,15N2 TFA
DLPLTFGGGT-Lys-13C6,15N2 (TFA) is a deuterated labeled DLPLTFGGGTK .

HY-P5168AS

GPSVFPLAPSSK-13C6,15N2 TFA
GPSVFPLAPSSK- ¹³C₆, ¹⁵N₂ TFA is the ¹³C- and ¹⁵N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .

HY-P5168S

GPSVFPLAPSSK-13C6,15N2
GPSVFPLAPSSK- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .

HY-P1033S

[Pyr1]-Apelin-13, Gly(15N) TFA
Pyr1]-Apelin-13, Gly(15N) TFA is a Gly ¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor agonist .

HY-159046S

ASGITFSNSGMHW(Val-13C5,15N)R TFA
ASGITFSNSGMHW(Val-13C5,15N)R TFA is an isotope of ASGITFSNSGMHWVR TFA labeled with ¹³C and ¹⁵N .

HY-P11344S

LLIYFASQSISGIPDR-13C2,15N
LLIYFASQSISGIPDR- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled LLIYFASQSISGIPDR.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80878

	Pyruvate Dehydrogenase E1 alpha Antibody (YA681) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; Phe1A; Pyruvate Dehydrogenase (lipoamide) alpha 1; Pyruvate dehydrogenase complex; E1 alpha polypeptide 1; Pyruvate Dehydrogenase E1 alpha; Pyruvate dehydrogenase E1 com	WB, ICC/IF	Human, Mouse
	Pyruvate Dehydrogenase E1 alpha Antibody (YA681) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P81951

	PAH Antibody (YA1696) Phe-4-monooxygenase	WB	Human, Mouse, Rat
	PAH Antibody (YA1696) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAH.

HY-P84011

	Pyruvate Dehydrogenase E1 alpha Antibody (YA3708) PDHA; PDHAD; Phe1A; PDHCE1A	WB, IP, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 alpha Antibody (YA3708) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P81949

	Lipoamide Dehydrogenase Antibody (YA1694) Diaphorase; Dihydrolipoamide dehydrogenase; DLDD; DLDH; GCSL; LAD; lipoamide dehydrogenase; Lipoamide reductase; Lipoyl dehydrogenase; Phe3	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Lipoamide Dehydrogenase Antibody (YA1694) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lipoamide Dehydrogenase.

HY-P82629

	Pyruvate Dehydrogenase E1 beta Antibody (YA2374) pdhB; DHBD; PDHE1 B; PDHE1-B; Phe1B	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 beta Antibody (YA2374) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 beta.

HY-P85449

	Pyruvate Dehydrogenase E1 alpha Antibody (YA5141) PDHA1; Phe1A; Pyruvate dehydrogenase E1 component subunit alpha; somatic form, mitochondrial; PDHE1-A type I	WB, ICC/IF	Human, Mouse, Rat, Bovine, Dog, Pig
	Pyruvate Dehydrogenase E1 alpha Antibody (YA5141) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P86544

	Pyruvate Dehydrogenase E1 alpha Antibody (YA6236) PDHA1; Phe1A; Pyruvate dehydrogenase E1 component subunit alpha; somatic form, mitochondrial; PDHE1-A type I	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Pyruvate Dehydrogenase E1 alpha Antibody (YA6236) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

HY-P85504

	Pyruvate Dehydrogenase E1 alpha Antibody (YA5196) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; Phe1A; Pyruvate Dehydrogenase; lipoamide; alpha 1; Pyruvate dehydrogenase complex, E1 alpha polypeptide 1; Pyruvate Dehydrogenase E1 alpha; Pyruvate dehydrogenase E1 component subunit alpha; Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; somatic form.	WB, ICC	Human, Mouse
	Pyruvate Dehydrogenase E1 alpha Antibody (YA5196) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pyruvate Dehydrogenase E1 alpha.

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Cat. No.	Product Name		Classification

HY-P10303

*Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]* Cyclo[RGDfK(Azide)]		Azide
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .

HY-162946

Alkyne-P60		Alkynes
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).

HY-P10758

Alkyne-βAG-TOCA		Alkynes
Alkyne-βAG-TOCA, an octreotide derivative, targets somatostatin receptor type 2 (SST2) . Alkyne-βAG-TOCA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-131088

*N3-PEG8-Phe-Lys-PABC-Gefitinib*		Azide
N3-PEG8-Phe-Lys-PABC-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC. N3-PEG8-Phe-Lys-PABC-Gefitinib is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151837

*H-L-Phe(4-NH-Poc)-OH hydrochloride*		Alkynes
H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151825

*Fmoc-L-Phe(4-NH-Poc)-OH*		Alkynes
Fmoc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in solid-phase peptide synthesis. Poc-group can be further modified using Click-chemistry .

HY-151824

*Boc-L-Phe(4-NH-Poc)-OH*		Alkynes
Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-B0361

Aspartame 1 Publications Verification SC-18862		Sweetening Agents
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

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