2. Immunology/Inflammation Apoptosis NF-κB Metabolic Enzyme/Protease
  3. Complement System Apoptosis Reactive Oxygen Species (ROS)
  4. BM213

BM213 is a selective C5aR agonist, with an EC50 of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury.

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Custom Peptide Synthesis

BM213

BM213 Chemical Structure

CAS No. : 2891606-02-1

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Based on 2 publication(s) in Google Scholar

BM213 Related Antibodies

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Description

BM213 is a selective C5aR agonist, with an EC50 of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury[1].

IC50 & Target[1]

C5aR

59 nM (EC50)

In Vivo

BM213 (1 mg/kg, i.p., once daily in the evening, 3 days) significantly induces ventricular dilationin in male Sprague-Dawley (SD) rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley (SD) rats (200±20 g)[1]
Dosage: 1 mg/kg
Administration: i.p., once daily in the evening, 3 days
Result: Induced significant ventricular dilation.
Elevated serum levels of CK-MB, cTnT and IL-1β.
Up-regulated plasma concentrations of C5a, C5b-9, CCL3, CXCL1 and NETs.
Increased myocardial mRNA expression of C5ar1, Mpo and Ne.
Enhanced myocardial protein levels of C5aR1, MPO, NE and CitH3.
Promoted myocardial ROS production.
Induced cardiomyocyte apoptosis.
Molecular Weight

915.09

Formula

C43H70N12O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Phe-Lys-Pro-Leu-Ala-Ala-Ala-Arg
Sequence Shortening

Ac-FKPLAAAR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (54.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0928 mL 5.4639 mL 10.9279 mL
5 mM 0.2186 mL 1.0928 mL 2.1856 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (109.28 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0928 mL 5.4639 mL 10.9279 mL 27.3197 mL
5 mM 0.2186 mL 1.0928 mL 2.1856 mL 5.4639 mL
10 mM 0.1093 mL 0.5464 mL 1.0928 mL 2.7320 mL
15 mM 0.0729 mL 0.3643 mL 0.7285 mL 1.8213 mL
20 mM 0.0546 mL 0.2732 mL 0.5464 mL 1.3660 mL
25 mM 0.0437 mL 0.2186 mL 0.4371 mL 1.0928 mL
30 mM 0.0364 mL 0.1821 mL 0.3643 mL 0.9107 mL
40 mM 0.0273 mL 0.1366 mL 0.2732 mL 0.6830 mL
50 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5464 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BM213 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BM2132891606-02-1BM 213BM-213Complement SystemApoptosisReactive Oxygen Species (ROS)myocardial ischemia/reperfusion (I/R) injuryC5aRcardiomyocyteInhibitorinhibitorinhibit

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