2. Immunology/Inflammation Cell Cycle/DNA Damage NF-κB Apoptosis Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Reactive Oxygen Species (ROS) ATM/ATR MDM-2/p53 MMP Keap1-Nrf2 HSP
  4. Hexapeptide-11

Hexapeptide-11 is an anti-aging peptide that can protect fibroblasts from premature cell senescence mediated by oxidative stress. Hexapeptide-11 is also a potential stimulator of hyaluronic acid in keratinocytes, and can enhance skin barrier function by upregulating the expression of HAS2 and EGR3, and downregulating the expression of HYAL2. Hexapeptide-11 can also improve skin elasticity.

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Hexapeptide-11 Chemical Structure

Hexapeptide-11 Chemical Structure

CAS No. : 161258-30-6

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Based on 1 publication(s) in Google Scholar

Hexapeptide-11 Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

Hexapeptide-11 is an anti-aging peptide that can protect fibroblasts from premature cell senescence mediated by oxidative stress. Hexapeptide-11 is also a potential stimulator of hyaluronic acid in keratinocytes, and can enhance skin barrier function by upregulating the expression of HAS2 and EGR3, and downregulating the expression of HYAL2. Hexapeptide-11 can also improve skin elasticity[1][2][3].

In Vitro

Hexapeptide-11 (2-5% v/v; 24-96 h) upregulates the expression of genes related to the proteostasis network in a dose- and time-dependent manner in human lung embryonic fibroblasts (IMR90) and human newborn foreskin fibroblasts (BJs), including genes related to proteasome, autophagy, chaperones, and antioxidant responses[1].
Hexapeptide-11 (5% v/v; 144 h) protects IMR90 cells against H2O2-mediated premature senescence and suppresses the upregulation of p53 and p21[1].
Hexapeptide-11 (1-5% v/v; 24 h) dose-dependently activates the enzymatic activity of MMP-2 and MMP-9 in IMR90 cells[1].
Hexapeptide-11 (1%-5% v/v; 24-72 h) can inhibit the migration activity of IMR90 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hexapeptide-11 Related Antibodies

Real Time qPCR[1]

Cell Line: IMR90 cells
Concentration: 2 % and 5 % v/v
Incubation Time: 24 h
Result: Increased the expression of 20S and 19S proteasome subunits genes (α7, β1, β2, β5, rpn6, rpn11).
Increased the expression of genes related to ALS functionality (i.e. becn1, sqstm1 and hdac6, along with the cathepsins ctsl and ctsd).
Resulted in the upregulation of molecular chaperones genes (hsf1, hsp27, hsp70, hsp90 and clu).
Increased the expression of genes related to cellular antioxidant responses, namely nrf2 and keap1, along with downstream transcriptional targets of Nrf2 (i.e. the nqo1 and txnrd1 genes).
Molecular Weight

676.80

Formula

C36H48N6O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Phe-Val-Ala-Pro-Phe-Pro
Sequence Shortening

FVAPFP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (147.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4775 mL 7.3877 mL 14.7754 mL
5 mM 0.2955 mL 1.4775 mL 2.9551 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4775 mL 7.3877 mL 14.7754 mL 36.9385 mL
5 mM 0.2955 mL 1.4775 mL 2.9551 mL 7.3877 mL
10 mM 0.1478 mL 0.7388 mL 1.4775 mL 3.6939 mL
15 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4626 mL
20 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8469 mL
25 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL
30 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2313 mL
40 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
50 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7388 mL
60 mM 0.0246 mL 0.1231 mL 0.2463 mL 0.6156 mL
80 mM 0.0185 mL 0.0923 mL 0.1847 mL 0.4617 mL
100 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.3694 mL
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Hexapeptide-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hexapeptide-11161258-30-6Hexapeptide11Hexapeptide 11Reactive Oxygen Species (ROS)ATM/ATRMDM-2/p53MMPKeap1-Nrf2HSPAtaxia telangiectasia mutatedATM and RAD3 relatedMatrix metalloproteinasesHeat shock proteinsdegenerative aging pathologiesoxidative stresspremature cellularIMR90BJsInhibitorinhibitorinhibit

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