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Valproic acid β-D-glucuronide-d<sub>6</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Decarboxylase (2) Amino Acid Derivatives (1334) Amino acid Transporter (4) Apical Sodium-Dependent Bile Acid Transporter (7) Fatty Acid Synthase (FASN) (15) Free Fatty Acid Receptor (8) G protein-coupled Bile Acid Receptor 1 (18) Hydroxycarboxylic Acid Receptor (HCAR) (2) P-glycoprotein (21) 11β-HSD (7) 5 alpha Reductase (6) 5-HT Receptor (110) ABA Receptor (1) Acetolactate Synthase (ALS) (2) Acetyl-CoA Carboxylase (6) Acyltransferase (5) ADC Linker (6) ADC Payload (15) Adenosine Receptor (20) Adenylate Cyclase (4) Adrenergic Receptor (110) AIM2 (2) Akt (27) Aldehyde Dehydrogenase (ALDH) (3) Aldose Reductase (1) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (3) AMPK (13) Amyloid-β (18) Anaplastic lymphoma kinase (ALK) (10) Androgen Receptor (29) Angiotensin Receptor (27) Angiotensin-converting Enzyme (ACE) (33) Antibiotic (253) Antifolate (18) AP-1 (4) Apelin Receptor (APJ) (1) Apolipoprotein (1) Apoptosis (449) Arenavirus (1) Aryl Hydrocarbon Receptor (12) ASCT 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Carboxylase (PC) (2) Pyruvate Kinase (3) Quinone Reductase (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (11) RAR/RXR (25) Ras (4) Reactive Oxygen Species (ROS) (104) Reference Standards (203) Renin (2) RET (7) Reverse Transcriptase (19) RIP kinase (1) ROCK (8) ROR (5) ROS Kinase (10) RSV (9) RXFP Receptor (1) SARS-CoV (60) Scavenger Receptor Class B type I (SR-BI） (2) Secretin Receptor (2) Ser/Thr Protease (6) Serotonin Transporter (37) SGLT (9) Sialyltransferase (1) Sigma Receptor (4) Sirtuin (9) Small Interfering RNA (siRNA) (5) Smo (1) SOD (2) Sodium Channel (51) Somatostatin Receptor (3) Src (9) STAT (16) Stearoyl-CoA Desaturase (SCD) (6) Steroid Sulfatase (1) STING (2) Succinate Dehydrogenase (1) Survivin (1) Syk (1) TAM Receptor (3) Taste Receptor (4) Tau Protein (4) Telomerase (1) TET Protein (1) TGF-beta/Smad (9) Thrombin (12) Thrombopoietin Receptor (5) Thymidylate Synthase (5) Thyroid Hormone Receptor (8) TMV (2) TNF Receptor (17) Toll-like Receptor (TLR) (9) TOPK (5) Topoisomerase (31) Transmembrane Glycoprotein (1) Trk Receptor (5) TRP Channel (27) TrxR (1) Tryptophan Hydroxylase (1) Tyrosinase (13) Tyrosine Hydroxylase (1) URAT1 (10) Urea Transporter (1) Vasopressin Receptor (6) VD/VDR (18) VEGFR (36) Virus Protease (19) VKOR (1) WDR5 (1) Wee1 (1) Wnt (1) Xanthine Oxidase (14) YAP (1) α-synuclein (4) β-catenin (5) β-glucuronidase (2) γ-Glutamyl Transferase (GGT) (1) γ-secretase (1)
By Research Areas:	Cancer (1456) Cardiovascular Disease (473) Endocrinology (318) Infection (766) Inflammation/Immunology (785) Metabolic Disease (1004) Neurological Disease (814)
Click Chemistry:	Labeling and Fluorescence Imaging (6) Azide (41) Alkynes (55)
Oligonucleotides:	A (1) C (4) G (2) Phospholipids (4) siRNA drugs (2) siRNAs (5) Pegylated Lipids (4) U (2) Liposomal Film-forming Agents (1) Disintegrants (1) Mouse Pre-designed siRNA Sets (1) Cationic Lipids (7) Human Pre-designed siRNA Sets (1) Polymers (1) Nucleosides and their Analogs (4) Thickeners (1) Nucleoside Phosphoramidites (3) Rat Pre-designed siRNA Sets (1) Suspending Agents (1) Solubilizing Agents (1) Freeze-drying Protective Agents (1) Cholesterol (2) Nucleotides and their Analogs (9) Emulsifiers (2) Sweetening Agents (1)

7604

Inhibitors & Agonists

Fluorescent Dye

301

Biochemical Assay Reagents

1631

Peptides

MCE Kits

Inhibitory Antibodies

526

Natural
Products

Recombinant Proteins

4262

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Amino Acid Oxidase Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter P-glycoprotein G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142119S

*5-Hydroxy tryptophol β-D-glucuronide-d4*	NF-κB mAChR Isotope-Labeled Compounds	Others
5-Hydroxy tryptophol β-D-glucuronide-d₄ is the deuterium labeled 5-Hydroxy tryptophol β-D-glucuronide .

HY-132723AS

*17β-Estradiol-3-β-D-glucuronide-d3 sodium*	Isotope-Labeled Compounds	Others
17β-Estradiol-3-β-D-glucuronide-d₃ (sodium) is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-W769286

Valproic acid β-D-glucuronide-d15	Isotope-Labeled Compounds HDAC	Cancer
Valproic acid β-D-glucuronide-d₁₅ is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .

HY-W700378

Valproic acid β-D-glucuronide-d6-1	Isotope-Labeled Compounds HDAC	Cancer
Valproic acid β-D-glucuronide-d₆-1 is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .

HY-137522S

*Zidovudine O-β-D-glucuronide-d3 sodium* 3'-Azido-3'-deoxythymidine β-D-glucuronide-d<sub>3sub> sodium	Isotope-Labeled Compounds Drug Metabolite	Others
Zidovudine O-β-D-glucuronide-d₃ (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .

HY-W008917S1

*Estrone β-D-glucuronide-d4 sodium*	Isotope-Labeled Compounds	Others
Estrone β-D-glucuronide-d₄ (sodium) is deuterium labeled Estrone beta-D-glucuronide sodium salt.

HY-W744370

*Raloxifene 6-β-D-glucuronide-d4 lithium*	Isotope-Labeled Compounds	Others
Raloxifene 6-β-D-glucuronide-d₄ lithium is the deuterium labeled Raloxifene 6-β-D-glucuronide lithium.

HY-142581S

*1-Naphthol β-D-glucuronide-d7 sodium*	Isotope-Labeled Compounds	Others
1-Naphthol β-D-glucuronide-d₇ (sodium) is the deuterium labeled 1-Naphthol β-D-glucuronide sodium .

HY-132723S

*17β-Estradiol-3-β-D-glucuronide-d3*	Isotope-Labeled Compounds	Others
17β-Estradiol-3-β-D-glucuronide-d₃ is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-113018S

*Ibuprofen acyl-β-D-glucuronide-d3* Ibuprofen glucuronide-d<sub>3sub>	Isotope-Labeled Compounds	Others
Ibuprofen acyl-β-D-glucuronide-d₃ is the deuterium labeled Ibuprofen acyl-β-D-glucuronide .

HY-W766293

*1-Hydroxypyrene β-D-glucuronide-d9*	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
1-Hydroxypyrene β-D-glucuronide-d₉ is the deuterium labeled 1-Hydroxypyrene β-D-glucuronide (HY-W699225). 1-Hydroxypyrene β-D-glucuronide is a biochemical reagent.

HY-142279S

*17β-Estradiol 17-acetate 3-β-D-glucuronide-d3*	Isotope-Labeled Compounds	Others
17β-Estradiol 17-acetate 3-β-D-glucuronide-d₃ is the deuterium labeled 17β-Estradiol 17-acetate 3-β-D-glucuronide .

HY-10585S1

Valproic acid-d6 VPA-d<sub>6sub>; 2-Propylpentanoic acid-d<sub>6sub>	HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₆ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-G0020S1

*Nicotine N-β-D-glucuronide-d3* Nicotine N-glucuronide-d<sub>3sub>	Isotope-Labeled Compounds	Others
Nicotine N-β-D-glucuronide-d₃ (Nicotine N-glucuronide-d₃) is a deuterium labeled compound.

HY-W701013

*Propofol beta-D-glucuronide-d17*	Isotope-Labeled Compounds	Others
Propofol beta-D-glucuronide-d₁₇ is deuterium labeled Propofol beta-D-glucuronide .

HY-142266S

*Retigabine N-β-D-glucuronide-d4*	Isotope-Labeled Compounds	Others
Retigabine N-β-D-glucuronide-d₄ is the deuterium labeled Retigabine N-β-D-glucuronide .

HY-10585AS1

Valproic acid-d14 sodium Sodium Valproate-d<sub>14sub> sodium	Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₁₄ (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

HY-122813S1

*Dabigatran acyl-β-D-glucuronide-d3 TFA*	Isotope-Labeled Compounds	Others
Dabigatran acyl-β-D-glucuronide-d₃ (TFA) is the deuterium labeled Dabigatran Acyl-β-D-Glucuronide trifluoroacetate .

HY-10585AS

Valproic acid-d7 sodium Sodium Valproate-d<sub>7sub>(sodium)	Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₇ (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-W768439

*Diosmetin 7-O-β-D-Glucuronide-d3 Sodium Salt*	Isotope-Labeled Compounds	Others
Diosmetin 7-O-β-D-Glucuronide-d₃ Sodium Salt is the deuterium labeled Diosmetin 7-O-β-D-Glucuronide Sodium Salt.

HY-W705647

*rac Erythro Dihydrobupropion Beta-D-Glucuronide-d9*	Isotope-Labeled Compounds	Others
rac Erythro Dihydrobupropion Beta-D-Glucuronide-d₉ is the deuterium labeled rac Erythro Dihydrobupropion Beta-D-Glucuronide.

HY-W740902

*(E,Z)-Tamoxifen-N-β-D-glucuronide-d5*	Isotope-Labeled Compounds	Others
(E,Z)-Tamoxifen-N-β-D-glucuronide-d₅ is the deuterium labeled (E,Z)-Tamoxifen-N-β-D-glucuronide.

HY-10585S3

Valproic acid-d4 sodium VPA-d<sub>4sub> sodium; 2-Propylpentanoic acid-d<sub>4sub> sodium	Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₄ (sodium) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

HY-10585S2

Valproic acid-d15 VPA-d<sub>15sub>; 2-Propylpentanoic acid-d<sub>15sub>	HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₁₅ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-10585S

Valproic acid-d4 1 Publications Verification VPA-d<sub>4sub>; 2-Propylpentanoic acid-d<sub>4sub>	HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₄ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

HY-10585S4

Valproic acid-d4-1 VPA-d<sub>4sub>-1; 2-Propylpentanoic acid-d<sub>4sub>-1	Isotope-Labeled Compounds HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite	Cancer
Valproic acid-d₄-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-W756134

*Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium*	Isotope-Labeled Compounds Drug Metabolite FXR	Metabolic Disease
Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d₅ sodium is the deuterium labeled Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium. Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium is a metabolite of Chenodeoxycholic Acid (HY-76847) .

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-10585

Valproic acid 45+ Cited Publications Dipropylacetic acid	Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Valproic acid (VPA) is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-W400421

3-Hydroxyvalproic acid 3-Hydroxy VPA	Endogenous Metabolite	Metabolic Disease
3-Hydroxyvalproic acid (3-Hydroxy VPA) is a metabolite of valproic acid. 3-Hydroxyvalproic acid is a weak inhibitor of enzymes related to the mitochondrial β-oxidation pathway. 3-Hydroxyvalproic acid is promising for research of diseases related to abnormal valproic acid metabolism .

HY-10585R

Valproic acid (Standard) 30+ Cited Publications Dipropylacetic acid (Standard)	Reference Standards Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Valproic acid (Dipropylacetic Acid) (Standard) is an analytical standard for valproic acid. This product is intended for research and analytical applications. Valproic acid is an orally active HDAC inhibitor (IC₅₀=0.5-2 mM), inhibits the activity of HDAC1 (IC₅₀=400 μM), and induces the degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits the proliferation of small cell lung cancer (SCLC) cells. Valproic acid is used in the study of epilepsy, bipolar disorder, metabolic diseases, HIV infection, and migraine ^[6] .

HY-10585AR

Valproic acid sodium (Standard) Sodium Valproate sodium (Standard)	Organoid Reference Standards HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Valproic acid (sodium) (Standard) is the analytical standard of Valproic acid (sodium). This product is intended for research and analytical applications. Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-W400496

**Valproic acid β-D-glucuronide**	HDAC	Cancer
Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .

HY-10585A

Valproic acid sodium 45+ Cited Publications Sodium Valproate sodium	Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-124087

(±)-2-Propyl-4-pentenoic acid 4-en-VPA; 2-Allylpentanoic acid	Drug Metabolite	Others
(±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-158238S

*Silodosin β-D-glucuronide-d4* Silodosin glucuronide-d<sub>4sub>	Isotope-Labeled Compounds	Others
Silodosin glucoronide-d₄ is deuterium labeled Silodosin glucoronide .

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-17623S

Tegoprazan-d6 CJ-12420-d<sub>6sub>; RQ-00000004-d<sub>6sub>	Proton Pump Na+/K+ ATPase	Metabolic Disease
Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H ⁺/K ⁺-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases .

HY-124087R

(±)-2-Propyl-4-pentenoic acid (Standard) 4-en-VPA (Standard); 2-Allylpentanoic acid (Standard)	Reference Standards Drug Metabolite	Others
(±)-2-Propyl-4-pentenoic acid (Standard) is the analytical standard of (±)-2-Propyl-4-pentenoic acid. This product is intended for research and analytical applications. (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].

HY-10585AG

Valproic acid (sodium) Sodium Valproate (sodium)	Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-133160

Valproic acid hydroxamate VPA-HA	Drug Derivative	Neurological Disease
Valproic acid hydroxamate (VPA-HA) has shown anticonvulsant activity in a mouse neural tube defect model, without any teratogenic effects .

HY-135391S

*Ezetimibe phenoxy glucuronide-d4* Ezetimibe glucuronide-d<sub>4sub>; Ezetimibe β-D-glucuronide-d<sub>4sub>	Drug Metabolite	Metabolic Disease
Ezetimibe phenoxy glucuronide-d₄ is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .

HY-W016034S

*Acetaminophen glucuronide-d3 sodium salt* p-Acetamidophenyl β-D-glucuronide-d<sub>3sub> sodium salt; p-AAPG-d<sub>3sub> sodium salt	Isotope-Labeled Compounds	Others
Acetaminophen glucuronide-d₃ sodium salt is the deuterium labeled Acetaminophen glucuronide sodium salt.

HY-B0715S

Pentoxifylline-d6 BL-191-d<sub>6sub>; PTX-d<sub>6sub>; Oxpentifylline-d<sub>6sub>	Phosphodiesterase (PDE) Autophagy HIV	Cardiovascular Disease Cancer
Pentoxifylline-d₆ is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-15494S1

Picropodophyllin-d6 AXL1717-d<sub>6sub>; Picropodophyllotoxin-d<sub>6sub>; PPP-d<sub>6sub>	Isotope-Labeled Compounds IGF-1R Apoptosis	Endocrinology Cancer
Picropodophyllin-d₆ (AXL1717-d₆) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-B1873S

Methoxychlor-d6 DMDT-d<sub>6sub>; Methoxcide-d<sub>6sub>; Methoxy-DDT-d<sub>6sub>	Isotope-Labeled Compounds	Others
Methoxychlor-d₆ is the deuterium labeled Methoxychlor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10585

Valproic acid Maximum Cited Publications 48 Publications Verification Dipropylacetic acid	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
Valproic acid (VPA) is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-10585A

Valproic acid sodium Maximum Cited Publications 48 Publications Verification Sodium Valproate sodium	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-10585AR

Valproic acid sodium (Standard) Sodium Valproate sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Organoid Reference Standards HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
Valproic acid (sodium) (Standard) is the analytical standard of Valproic acid (sodium). This product is intended for research and analytical applications. Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-10585B

Valproic acid (sodium)(2:1) VPA (sodium)(2:1); 2-Propylpentanoic acid (sodium)(2:1)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium (2:1) activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium (2:1) is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches ^[6] .

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Other disease Disease markers Endogenous metabolite	Endogenous Metabolite
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

HY-125833R

Alpha-Naphthoflavone (Standard)	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	Reference Standards NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-N15496

Fusaproliferin FUS	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reactive Oxygen Species (ROS) NO Synthase Interleukin Related TNF Receptor p38 MAPK ERK IKK NF-κB
Fusaproliferin is a sesterterpene mycotoxin isolated from Fusarium solani. Fusaproliferin reverse Lipopolysaccharides (HY-D1056) stimulation and the NF-κB and MAPKs signaling pathways contribute to the anti-inflammatory process. Fusaproliferin exhibits affinity for the TLR4 protein with K_D values of 28.6 μM. Fusaproliferin shows cytotoxicity against pancreatic cancer cell with rapid and sub-micromolar IC₅₀ .

HY-W011370

Pelargonidin chloride 1 Publications Verification	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Quinone Reductase Reactive Oxygen Species (ROS)
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment .

HY-P2274R

Argifin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards Parasite
Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

HY-N0662R

Amentoflavone (Standard) Didemethyl-ginkgetin (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-B0504S

Creatinine-d3 5 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Isotope-Labeled Compounds Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle .

HY-W015424

N-Methyl-DL-glutamic acid 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Methyl-DL-glutamic acid is a L-Glutamic acid (HY-14608) analog with cytotoxic effects .

HY-30216AR

Leucic acid (Standard) α-Hydroxyisocaproic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Reference Standards
Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite .

HY-30216A

Leucic acid α-Hydroxyisocaproic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Leucic acid is an amino acid metabolite .

HY-N9140

Hulupinic acid	Structural Classification Natural Products Humulus lupulus L. Source classification Plants Moraceae	Others
Hulupinic acid is a prominent oxidation product of hop acids .

HY-N11420

Coronatine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields Agricultural Research	Bacterial Phytohormone
Coronatine is a plant growth regulator that mimicks the jasmonic acid-isoleucine conjugate (JA-Ile), targets the jasmonic acid receptor COI1, activates the jasmonic acid signaling pathway, thereby inhibiting salicylic acid (SA)-dependent defense responses. Coronatine antagonizes the stomatal closure, induces plant cell necrosis and chlorosis, interfers with plant hormone balance, thereby promoting pathogen infection .

HY-20897A

5-Bromo-L-tryptophan 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

HY-20897AR

5-Bromo-L-tryptophan (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
5-Bromo-L-tryptophan (Standard) is the analytical standard of 5-Bromo-L-tryptophan. This product is intended for research and analytical applications. 5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp. .

HY-W399297

Isodeoxycholic acid 1 Publications Verification 7α,12α-Dihydroxycholanoic acid	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is the 3β-epimer of ursodeoxycholic acid. Isodeoxycholic acid has the effect on choleresis and liver biochemistry .

HY-W399297R

Isodeoxycholic acid (Standard) 7α,12α-Dihydroxycholanoic acid (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite Reference Standards
Amprenavir (Standard) is the analytical standard of Amprenavir. This product is intended for research and analytical applications. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.

HY-N8268R

Nordeoxycholic acid (Standard) 3α,12α-Dihydroxynorcholanic acid (Standard)	Animals Source classification	Drug Metabolite Reference Standards
Reproterol (hydrochloride) (Standard) is the analytical standard of Reproterol (hydrochloride). This product is intended for research and analytical applications. Reproterol hydrochloride is a dual-acting beta2-adrenoceptor agonist and phosphodiesterase inhibitor. Reproterol hydrochloride is more potent than albuterol and feterol in stimulating cAMP production in human monocytes, demonstrating its potential in enhancing airway function. Furthermore, Reproterol significantly inhibited the production of LTB4, indicating its anti-inflammatory properties. Reproterol hydrochloride may have inhibitory effects in respiratory diseases such as asthma and COPD .

HY-W751418

N-Nervonoyl taurine (Z)-2-tetracos-15-enamidoethanesulfonic acid	Structural Classification Natural Products Source classification Endogenous metabolite	FAAH
N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .

HY-W013214

Ethyl arachidonate	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA) and can be added into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. Ethyl arachidonate is the main species of fatty acid ethyl esters (FAEE) in brain of alcohol-intoxicated subjects .

HY-N8268

Nordeoxycholic acid 3α,12α-Dihydroxynorcholanic acid	Animals Source classification	Others
Nordeoxycholic acid is a 23-carbon bile acid. Nordeoxycholic acid is a norcholic acid metabolite and a steroid human metabolite .

HY-N15317

Phocaecholic acid β-Phocaecholic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Drug Metabolite
Phocaecholic acid (β-Phocaecholic acid) is a bile acid found in duck bile. Phocaecholic acid can be excreted into bile and partially decarboxylated to nor-chenodeoxycholic acid in rats. Phocaecholic acid is promising for research of bile acid metabolism and related diseases .

HY-N0169B

Murideoxycholic acid 1 Publications Verification	Structural Classification Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields Steroids	Endogenous Metabolite
Murideoxycholic acid is a 6 beta-hydroxylated bile acid .

HY-N11909

8-O-4,8-O-4-Dehydrotriferulic acid	Structural Classification Zea mays L. Ketones, Aldehydes, Acids Gramineae Source classification Plants	Others
8-O-4,8-O-4-Dehydrotriferulic acid is a dehydrotriferulic acid that can be isolated from saponified corn bran insoluble fiber .

HY-N8500

Aristolochic acid Ia	Structural Classification Natural Products Aristolochia debilis Sieb. et Zucc. Source classification Plants Aristolochiaceae	Drug Metabolite
Aristolochic acid Ia is an oxidative metabolite of aristolochic acid I, which can be used to study the detoxification pathway of aristolochic acid metabolism .

HY-112653A

(±)8-HETE 8-Hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE).

HY-W051164

5-Hydroxyvanillin	Infection Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxyvanillin is the product of the bacterial and fungal breakdown of ferulic acid, an abundant component in cell walls of found in many seed and leaves .

HY-N6072

Seco-neokadsuranic acid A	Triterpenes Structural Classification Ketones, Aldehydes, Acids Terpenoids Source classification Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Seco-neokadsuranic acid A is a triterpene acid isolated from Kadsura coccinea .

HY-W747583

Apocholic acid	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite
Apocholic acid, a Bile acid, is an endogenous metabolite .

HY-157732

1,2-Dimyristoyl-3-palmitoyl-rac-glycerol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,2-Dimyristoyl-3-palmitoyl-rac-glycerol (MMP) is a triacylglycerol that contains myristic acid and palmitic acid .

HY-W403933R

12-Ketochenodeoxycholic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Autophagy Reference Standards
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an intermediate fatty acid in the biosynthetic pathway from α-linolenic acid to VLC ω-3 PUFA. The conversion efficiency of stearidonic acid is higher than that of alpha-linolenic acid. Increasing the intake of stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can also be isolated from methanolic extracts of the brown alga Brachyphyllum gracilis .

HY-W403933

12-Ketochenodeoxycholic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Autophagy
12-Ketochenodeoxycholic acid 12 is a direct precursor of cholodeoxycholic acid (CDCA). Cholodeoxycholic acid is used to cholesterol gallstones and has chemotherapeutic properties that dissolve gallstones .

HY-116688R

2-Hydroxy-4-(methylthio)butyric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
2-Hydroxy-4-(methylthio)butyric acid (Standard) is the analytical standard of 2-Hydroxy-4-(methylthio)butyric acid. This product is intended for research and analytical applications. 2-Hydroxy-4-(methylthio)butyric acid is a dietary essential amino acid which is converted to Methionine (HY-13694) by 2-hydroxy acid dehydrogenase and 2-hydroxy acid oxidase. 2-Hydroxy-4-(methylthio)butyric acid is promising for research of gut disease .

HY-116688

2-Hydroxy-4-(methylthio)butyric acid	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Bacterial
2-Hydroxy-4-(methylthio)butyric acid is a dietary essential amino acid which is converted to Methionine (HY-13694) by 2-hydroxy acid dehydrogenase and 2-hydroxy acid oxidase. 2-Hydroxy-4-(methylthio)butyric acid is promising for research of gut disease .

HY-N7856

3-Oxooctadecanoic acid 3-Oxostearic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Others
3-Oxooctadecanoic acid (3-Oxostearic acid) is a saturated fatty acid (SFA). 3-Oxooctadecanoic acid is an intermediate product in fatty acid biosynthesis and it was converted from malonic acid via the enzyme .

HY-N0593

Deoxycholic acid 15+ Cited Publications Cholanoic acid; Desoxycholic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-N2855

Alphitolic acid 1 Publications Verification Aophitolic acid	Triterpenes Source classification Myrica nagi Plants Myricaceae	Apoptosis Autophagy TNF Receptor Akt NF-κB
Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research .

HY-N1652

2,3,8-Tri-O-methylellagic acid 3,3′,4-Tri-O-methylellagic acid	Monophenols Classification of Application Fields Neoboutonia macrocalyx Pax Source classification Other Diseases Phenols Euphorbiaceae Plants Disease Research Fields	Others
2,3,8-Tri-O-methylellagic acid is a terpenoids that can be isolated from the stem bark of Neoboutonia macrocalyx. 2,3,8-Tri-O-methylellagic acid is found to be 50 times more active than the parent ellagic acid .

Cat. No.	Product Name	Chemical Structure

HY-142119S

*5-Hydroxy tryptophol β-D-glucuronide-d4*
5-Hydroxy tryptophol β-D-glucuronide-d₄ is the deuterium labeled 5-Hydroxy tryptophol β-D-glucuronide .

HY-132723AS

*17β-Estradiol-3-β-D-glucuronide-d3 sodium*
17β-Estradiol-3-β-D-glucuronide-d₃ (sodium) is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-W769286

Valproic acid β-D-glucuronide-d15
Valproic acid β-D-glucuronide-d₁₅ is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .

HY-W700378

Valproic acid β-D-glucuronide-d6-1
Valproic acid β-D-glucuronide-d₆-1 is the deuterium labeled Valproic acid β-D-glucuronide (HY-W400496). Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .

HY-W008917S1

*Estrone β-D-glucuronide-d4 sodium*
Estrone β-D-glucuronide-d₄ (sodium) is deuterium labeled Estrone beta-D-glucuronide sodium salt.

HY-W744370

*Raloxifene 6-β-D-glucuronide-d4 lithium*
Raloxifene 6-β-D-glucuronide-d₄ lithium is the deuterium labeled Raloxifene 6-β-D-glucuronide lithium.

HY-142581S

*1-Naphthol β-D-glucuronide-d7 sodium*
1-Naphthol β-D-glucuronide-d₇ (sodium) is the deuterium labeled 1-Naphthol β-D-glucuronide sodium .

HY-132723S

*17β-Estradiol-3-β-D-glucuronide-d3*
17β-Estradiol-3-β-D-glucuronide-d₃ is the deuterium labeled 17β-Estradiol-3-β-D-glucuronide .

HY-113018S

*Ibuprofen acyl-β-D-glucuronide-d3*
Ibuprofen acyl-β-D-glucuronide-d₃ is the deuterium labeled Ibuprofen acyl-β-D-glucuronide .

HY-W766293

*1-Hydroxypyrene β-D-glucuronide-d9*
1-Hydroxypyrene β-D-glucuronide-d₉ is the deuterium labeled 1-Hydroxypyrene β-D-glucuronide (HY-W699225). 1-Hydroxypyrene β-D-glucuronide is a biochemical reagent.

HY-142279S

*17β-Estradiol 17-acetate 3-β-D-glucuronide-d3*
17β-Estradiol 17-acetate 3-β-D-glucuronide-d₃ is the deuterium labeled 17β-Estradiol 17-acetate 3-β-D-glucuronide .

HY-10585S1

Valproic acid-d6

Valproic acid-d₆ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-G0020S1

*Nicotine N-β-D-glucuronide-d3*
Nicotine N-β-D-glucuronide-d₃ (Nicotine N-glucuronide-d₃) is a deuterium labeled compound.

HY-W701013

*Propofol beta-D-glucuronide-d17*
Propofol beta-D-glucuronide-d₁₇ is deuterium labeled Propofol beta-D-glucuronide .

HY-142266S

*Retigabine N-β-D-glucuronide-d4*
Retigabine N-β-D-glucuronide-d₄ is the deuterium labeled Retigabine N-β-D-glucuronide .

HY-10585AS1

Valproic acid-d14 sodium

Valproic acid-d₁₄ (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

HY-122813S1

*Dabigatran acyl-β-D-glucuronide-d3 TFA*
Dabigatran acyl-β-D-glucuronide-d₃ (TFA) is the deuterium labeled Dabigatran Acyl-β-D-Glucuronide trifluoroacetate .

HY-10585AS

Valproic acid-d7 sodium

Valproic acid-d₇ (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-W768439

*Diosmetin 7-O-β-D-Glucuronide-d3 Sodium Salt*
Diosmetin 7-O-β-D-Glucuronide-d₃ Sodium Salt is the deuterium labeled Diosmetin 7-O-β-D-Glucuronide Sodium Salt.

HY-W705647

*rac Erythro Dihydrobupropion Beta-D-Glucuronide-d9*
rac Erythro Dihydrobupropion Beta-D-Glucuronide-d₉ is the deuterium labeled rac Erythro Dihydrobupropion Beta-D-Glucuronide.

HY-W740902

*(E,Z)-Tamoxifen-N-β-D-glucuronide-d5*
(E,Z)-Tamoxifen-N-β-D-glucuronide-d₅ is the deuterium labeled (E,Z)-Tamoxifen-N-β-D-glucuronide.

HY-10585S3

Valproic acid-d4 sodium

Valproic acid-d₄ (sodium) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

HY-10585S2

Valproic acid-d15

Valproic acid-d₁₅ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-10585S

Valproic acid-d4

1 Publications Verification

Valproic acid-d₄ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

HY-10585S4

Valproic acid-d4-1

Valproic acid-d₄-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .

HY-W756134

*Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium*
Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d₅ sodium is the deuterium labeled Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium. Chenodeoxycholic acid 24-acyl-β-D-glucuronide sodium is a metabolite of Chenodeoxycholic Acid (HY-76847) .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-158238S

*Silodosin β-D-glucuronide-d4*
Silodosin glucoronide-d₄ is deuterium labeled Silodosin glucoronide .

HY-17623S

Tegoprazan-d6

Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H ⁺/K ⁺-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases .

HY-135391S

*Ezetimibe phenoxy glucuronide-d4*
Ezetimibe phenoxy glucuronide-d₄ is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .

HY-W016034S

*Acetaminophen glucuronide-d3 sodium salt*
Acetaminophen glucuronide-d₃ sodium salt is the deuterium labeled Acetaminophen glucuronide sodium salt.

HY-B0715S

Pentoxifylline-d6

Pentoxifylline-d₆ is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-15494S1

Picropodophyllin-d6
Picropodophyllin-d₆ (AXL1717-d₆) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

HY-B1873S

Methoxychlor-d6
Methoxychlor-d₆ is the deuterium labeled Methoxychlor .

HY-B0236S

6-Aminocaproic acid-d6

6-Aminocaproic acid-d₆ is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders .

HY-B1850S

Halosulfuron-methyl-d6
Halosulfuron-methyl-d₆ (Inpool-d₆) is deuterium labeled Halosulfuron-methyl. Halosulfuron-methyl is a pyrazole sulfonylurea herbicide .

HY-N1214S

Squalene-d6
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-N0537S9

Xylose-d6
Xylose-d₆ is the deuterium labeled Xylose.

HY-B0696S

Tiagabine-d6
Tiagabine-d₆ (NO050328-d₆) is deuterium labeled Tiagabine. Tiagabine (NO050328) is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC₅₀s of 67, 446 and 182 nM for [ ³H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .

HY-B0457S1

Clomipramine-d6 hydrochloride
Clomipramine-d₆ (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC₅₀ value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .

HY-76542S

Vitamin D2-d6
Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D .

HY-16069S

Tucatinib-d6
Tucatinib-d₆ (Irbinitinib-d₆) is deuterium labeled Tucatinib. Tucatinib (Irbinitinib) is a potent, orally active and selective HER2 inhibitor with an IC₅₀ of 8 nM .

HY-41681S

6-Chloro-1-hexanol-d6
6-Chloro-1-hexanol-d₆ is the deuterium labeled 6-Chloro-1-hexanol .

HY-W019596S

Ethyl 4-(dimethylamino)benzoate-d6
Ethyl 4-(dimethylamino)benzoate-d₆ (PI-EDB-d₆) is deuterium labeled Ethyl 4-(dimethylamino)benzoate .

HY-50896S

Erlotinib-d6
Erlotinib-d₆ (CP-358774 D₆) is a deuterium labeled Erlotinib (CP-358774). Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC₅₀ of 2 nM for human EGFR . Erlotinib-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13011S1

Alectinib-d6
Alectinib-d₆ is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

HY-14740S1

Elvitegravir-d6
Elvitegravir-d₆ (GS-9137-d₆) is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively .

HY-12008S

Erlotinib-d6 hydrochloride
Erlotinib-d₆ hydrochloride a deuterium labeled Erlotinib Hydrochloride. Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC₅₀ of 2 nM . Erlotinib-d6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15531S1

Venetoclax-d6
Venetoclax-d₆ (ABT-199-d₆) is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy .

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