2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Caspase PARP Bcl-2 Family
  4. Apoptosis inducer 45

Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer.

For research use only. We do not sell to patients.

Apoptosis inducer 45

Apoptosis inducer 45 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Apoptosis inducer 45 Related Antibodies

Top Publications Citing Use of Products

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer[1].

IC50 & Target[1]

Caspase 3

 

Caspase 9

 

Caspase 8

 

PARP

 

Bax

 

Bcl-2

 

In Vitro

Apoptosis inducer 45 (Compound 11s) inhibits cell proliferation with IC50 values of 3.56, 4.93, 7.76 and 13.35 μM against A549, MCF-7, HL-7702 and MDA-MB-231 cells[1].
Apoptosis inducer 45 (2.5-10 μM, 24 h) induces MCF-7 cell apoptosis via both the exogenous and endogenous pathways[1].
Apoptosis inducer 45 (2.5-10 μM, 24 h-14 d) shows a concentration- and time-dependent inhibition of MCF-7 cell growth and inhibits colony formation[1].
Apoptosis inducer 45 (2.5-10 μM, 72 h) significantly reduces the migration ability of the MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 45 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2.5, 5 and 10 μM
Incubation Time: 24 h
Result: led to the typical apoptotic morphological characteristics of MCF-7 cells.
Increased apoptosis rates as the concentration rises.

Cell Migration Assay [1]

Cell Line: MCF-7 cells
Concentration: 2.5, 5 and 10 μM
Incubation Time: 72 h
Result: Significantly reduced the migration ability, and the migration inhibition effect persisted for 72 hours of observation.
Molecular Weight

639.91

Formula

C41H57N3O3
SMILES

[H][C@]1(C(CC[C@@]2(C(C)([C@@H](CC[C@@]12C)O)C)[H])=C)CC/C(C)=C/C(N3CCN(CC3)CC4=CC=C(C=C4)C(NCCC5=CC=C(C=C5)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Apoptosis inducer 45 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 45Apoptosis inducer45Apoptosis inducer-45ApoptosisCaspasePARPBcl-2 Familypoly ADP ribose polymeraseAlepterolic acidStructural modificationPiperazineBreast cancerHybridInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Apoptosis inducer 45
Cat. No.:
HY-178099
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.