Phaseic acid 

Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC₅₀ of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect^[1][2].

Phaseic acid (10 µM, 3 h) promotes the stomatal closure, reduces water evaporation in Commelina communis leaves^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phaseic acid (50 mg/mL, intraventricular injection, continuous infusion for 3 days) ameliorates ischemic brain lesions in mouse cerebral artery occlusion (MCAO) models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

280.32

C₁₅H₂₀O₅

24394-14-7

Solid

White to off-white

O=C(O)/C=C(C)\C=C\[C@]1(O)[C@]2(C)CC(C[C@@]1(C)OC2)=O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Pedro L Rodriguez, et al. Abscisic Acid Catabolism Generates Phaseic Acid, a Molecule Able to Activate a Subset of ABA Receptors. Mol Plant. 2016 Nov 7;9(11):1448-1450.  [Content Brief]

  [2]. Hou ST, et al., Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain. J Biol Chem. 2016 Dec 30;291(53):27007-27022.  [Content Brief]

  [3]. Sharkey TD, et al., Effects of phaseic Acid and dihydrophaseic Acid on stomata and the photosynthetic apparatus. Plant Physiol. 1980 Feb;65(2):291-7.  [Content Brief]