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Pyridine-3-sulfonic acid  (Synonyms: Pyridine-3-sulphonic acid)

Cat. No.: HY-W015467 Purity: 98.0%
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Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid.

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Pyridine-3-sulfonic acid

Pyridine-3-sulfonic acid Chemical Structure

CAS No. : 636-73-7

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Pyridine-3-sulfonic acid Related Antibodies

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Description

Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid[1][2].

In Vivo

Pyridine-3-sulfonic acid (1%, 1 g/100 g daily diet, p.o. with food, for 21 days) significantly reduces liver cholesterol synthesis in rats[1].
Pyridine-3-sulfonic acid (0.5-2 g, p.o. with food) does not interfere with the binding or metabolism of nicotinamide to coenzyme I/II in normal dogs or dogs deficient in Niacin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal diet and high cholesterol diet model established in male Wistar rats (150-160 g)[1]
Dosage: 1%, 1 g/100 g daily diet
Administration: Oral administration (p.o.) with food, for 21 days
Result: Did not significantly alter serum cholesterol levels in the normal diet group.
Did not show cholesterol-lowering activity in the high-cholesterol diet group.
Significantly reduced liver cholesterol synthesis.
Molecular Weight

159.17

Formula

C5H5NO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(C1=CC=CN=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

SDS (476 KB)

COA (254 KB) HNMR (118 KB)

Handling Instructions (2659 KB)
References
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Pyridine-3-sulfonic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridine-3-sulfonic acid636-73-7Pyridine-3-sulphonic acidOthersNicotinic acidWistar ratsAntimetabolitesHypocholesterolemic effectInhibitorinhibitorinhibit

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