1. Metabolic Enzyme/Protease Neuronal Signaling
  2. COMT Endogenous Metabolite
  3. 5-Hydroxyferulic acid

5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate.

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5-Hydroxyferulic acid Chemical Structure

5-Hydroxyferulic acid Chemical Structure

CAS No. : 1782-55-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 462 In-stock
Solution
10 mM * 1 mL in DMSO USD 462 In-stock
Solid
5 mg USD 420 In-stock
10 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Hydroxyferulic acid:

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  • Purity & Documentation

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Description

5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

The product of the alfalfa Caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase (COMT) catalyzed methylation of 5-Hydroxyferulic acid is sinapic acid. 5-Hydroxyferulic acid O-methyltransferase activities (pkat mg-1 protein) in stem material from COMT downregulates transgenic alfalfa[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

210.18

Formula

C10H10O5

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)/C=C/C1=CC(OC)=C(O)C(O)=C1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (475.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7578 mL 23.7891 mL 47.5783 mL
5 mM 0.9516 mL 4.7578 mL 9.5157 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.80%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7578 mL 23.7891 mL 47.5783 mL 118.9457 mL
5 mM 0.9516 mL 4.7578 mL 9.5157 mL 23.7891 mL
10 mM 0.4758 mL 2.3789 mL 4.7578 mL 11.8946 mL
15 mM 0.3172 mL 1.5859 mL 3.1719 mL 7.9297 mL
20 mM 0.2379 mL 1.1895 mL 2.3789 mL 5.9473 mL
25 mM 0.1903 mL 0.9516 mL 1.9031 mL 4.7578 mL
30 mM 0.1586 mL 0.7930 mL 1.5859 mL 3.9649 mL
40 mM 0.1189 mL 0.5947 mL 1.1895 mL 2.9736 mL
50 mM 0.0952 mL 0.4758 mL 0.9516 mL 2.3789 mL
60 mM 0.0793 mL 0.3965 mL 0.7930 mL 1.9824 mL
80 mM 0.0595 mL 0.2974 mL 0.5947 mL 1.4868 mL
100 mM 0.0476 mL 0.2379 mL 0.4758 mL 1.1895 mL
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Product Name:
5-Hydroxyferulic acid
Cat. No.:
HY-133068
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