2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite iGluR
  4. 5'-Guanylic acid disodium salt

5'-Guanylic acid disodium salt  (Synonyms: 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt)

Cat. No.: HY-W010970 Purity: 99.53%
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COA
Handling Instructions Technical Support

5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations.

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5'-Guanylic acid disodium salt Chemical Structure

5'-Guanylic acid disodium salt Chemical Structure

CAS No. : 5550-12-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
1 g In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 5'-Guanylic acid disodium salt:

5'-Guanylic acid disodium salt Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 5'-Guanylic acid disodium salt

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Description

5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

5'-Guanylic acid disodium salt (50-500 μM, 48 h) regulates the expression of genes involved in fatty acid metabolism, affects fatty acid composition in Oncorhynchus mykiss hepatocytes, and regulates fatty acid metabolism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5'-Guanylic acid disodium salt Related Antibodies

Real Time qPCR[1]

Cell Line: Oncorhynchus mykiss hepatocytes
Concentration: 50-500 μM
Incubation Time: 12-48 h
Result: Upregulated the expressions of Δ5 fads2, elovl2, elovl5 and srebp-1.
Downregulated the expression of pparα.
In Vivo

5'-Guanylic acid disodium salt (10-150 mg/kg, ip, single dose) exhibits anti-anxiety effect in Wistar rats models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats models[2].
Dosage: 10-150 mg/kg
Administration: ip, single dose
Result: Increased the time rats spent in the light zone in the light-dark box test.
Increased the time rats spent in the open arms in the elevated plus maze test.
Molecular Weight

407.18

Formula

C10H12N5Na2O8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O1)(O[Na])O[Na]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (122.80 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4559 mL 12.2796 mL 24.5592 mL
5 mM 0.4912 mL 2.4559 mL 4.9118 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (122.80 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.53%

SDS (393 KB)

COA (251 KB) HNMR (243 KB) RP-HPLC (204 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4559 mL 12.2796 mL 24.5592 mL 61.3979 mL
5 mM 0.4912 mL 2.4559 mL 4.9118 mL 12.2796 mL
10 mM 0.2456 mL 1.2280 mL 2.4559 mL 6.1398 mL
15 mM 0.1637 mL 0.8186 mL 1.6373 mL 4.0932 mL
20 mM 0.1228 mL 0.6140 mL 1.2280 mL 3.0699 mL
25 mM 0.0982 mL 0.4912 mL 0.9824 mL 2.4559 mL
30 mM 0.0819 mL 0.4093 mL 0.8186 mL 2.0466 mL
40 mM 0.0614 mL 0.3070 mL 0.6140 mL 1.5349 mL
50 mM 0.0491 mL 0.2456 mL 0.4912 mL 1.2280 mL
60 mM 0.0409 mL 0.2047 mL 0.4093 mL 1.0233 mL
80 mM 0.0307 mL 0.1535 mL 0.3070 mL 0.7675 mL
100 mM 0.0246 mL 0.1228 mL 0.2456 mL 0.6140 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5'-Guanylic acid disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Guanylic acid disodium5550-12-95'-GMP disodium5'-guanosine monophosphate disodiumEndogenous MetaboliteiGluRIonotropic glutamate receptorsanxietylong-chain polyunsaturated fatty acidInhibitorinhibitorinhibit

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