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Gln

" in MedChemExpress (MCE) Product Catalog:

1579

Inhibitors & Agonists

2

Fluorescent Dye

2

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1819

Peptides

40

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Products

1

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45

Isotope-Labeled Compounds

1

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1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101710
    Benzgalantamine

    Gln-1062

    		 Drug Intermediate Neurological Disease
    Benzgalantamine (GLN-1062) is a pro-agent of galantamine, used for the treatment for Alzheimer’s disease.
    Benzgalantamine
  • HY-112861A
    Gln-AMS TFA
    1 Publications Verification

    		 Aminoacyl-tRNA Synthetase Bacterial Infection
    Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 µM.
    Gln-AMS TFA
  • HY-112861
    Gln-AMS
    1 Publications Verification

    		 Aminoacyl-tRNA Synthetase Bacterial Infection
    Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes.
    Gln-AMS
  • HY-P1366
    des-​Gln14-​Ghrelin

    		GHSR Metabolic Disease
    des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca 2+]i in CHO-GHSR62 cells, with an EC50 of 2.4 nM .
    des-​Gln14-​Ghrelin
  • HY-W009339
    Z-Gln-OH

    		Amino Acid Derivatives Others
    Z-Gln-OH is a glutamine derivative .
    Z-Gln-OH
  • HY-P1905
    [Gln8]-C517 (LH-RH), chicken

    		GnRH Receptor Endocrinology
    [Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.
    [Gln8]-C517 (LH-RH), chicken
  • HY-P4585
    (Gln22)-Amyloid β-Protein (1-42)

    		Amyloid-β Neurological Disease
    (Gln22)-Amyloid β-Protein (1-42) is a Dutch mutation (E22Q) form of β-Amyloid (1-42) (HY-P1363). (Gln22)-Amyloid β-Protein (1-42) exhibits enhanced fibrillogenic and pathogenic properties .
    (Gln22)-Amyloid β-Protein (1-42)
  • HY-P10040
    (Gln22)β-Amyloid (1-40) human

    		Amyloid-β Neurological Disease
    (Gln22)β-Amyloid (1-40) human is an amyloid beta protein (Aβ)-containing peptide used in Alzheimer's disease research .
    (Gln22)β-Amyloid (1-40) human
  • HY-P10315
    [Gln144]-PLP (139-151)

    Q144-PLP(139-151)

    		 Transmembrane Glycoprotein Others
    [Gln144]-PLP (139-151) is an experimental antigen used to study T cells respond to both autoantigens and cross-reactive non-autoantigens. [Gln144]-PLP (139-151) activates T cells by binding to T-cell Receptor (TCR), which triggers an immune response. [Gln144]-PLP (139-151) can be used to study the regulation of autoimmune diseases .
    [Gln144]-PLP (139-151)
  • HY-P1366A
    des-​Gln14-​Ghrelin TFA

    		GHSR Metabolic Disease
    des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca 2+]i in CHO-GHSR62 cells, with an EC50 of 2.4 nM .
    des-​Gln14-​Ghrelin TFA
  • HY-P3726
    Lys-Gln-Ala-Gly-Asp-Val

    		Integrin Inflammation/Immunology Cancer
    Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .
    Lys-Gln-Ala-Gly-Asp-Val
  • HY-P4323
    Boc-Gln-Arg-Arg-AMC

    		Fluorescent Dye Others
    Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Boc-Gln-Arg-Arg-AMC
  • HY-P4323A
    Boc-Gln-Arg-Arg-AMC acetate

    		Fluorescent Dye Others
    Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Boc-Gln-Arg-Arg-AMC acetate
  • HY-P4488
    H-Pro-Pro-Gln-OH

    		Dipeptidyl Peptidase Others
    H-Pro-Pro-Gln-OH is a oligopeptide with excellent dipeptidyl peptidase-IV (DPP-IV) inhibitory activity .
    H-Pro-Pro-Gln-OH
  • HY-134432A
    Boc-Gln-Ala-Arg-AMC hydrochloride

    		Ser/Thr Protease Others
    Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 .
    Boc-Gln-Ala-Arg-AMC hydrochloride
  • HY-134432B
    Boc-Gln-Ala-Arg-AMC acetate

    		Ser/Thr Protease Others
    Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
    Boc-Gln-Ala-Arg-AMC acetate
  • HY-P5415
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS

    		HIV Others
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS
  • HY-W010714
    Fmoc-D-Gln(Trt)-OH

    		Amino Acid Derivatives Others
    Fmoc-D-Gln(Trt)-OH is a glutamine derivative .
    Fmoc-D-Gln(Trt)-OH
  • HY-113003
    H-γ-Glu-Gln-OH

    γ-Glutamylglutamine; γ-Glu-Gln

    		 Amino Acid Derivatives Others Cancer
    H-γ-Glu-Gln-OH is a hydrophilic peptide and can be conjugated to drugs. The carrier composed of H-γ-Glu-Gln-OH has the characteristics of high water solubility and drug-loading capacity, good biocompatibility, low toxicity, improved tumor targeting ability, and anti-tumor efficacy .
    H-γ-Glu-Gln-OH
  • HY-W013081
    Fmoc-Gln(Trt)-OH

    		Biochemical Assay Reagents Others
    Fmoc-Gln(Trt)-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Fmoc-Gln(Trt)-OH
  • HY-P3882
    Fmoc-Ala-Glu-Gln-Lys-NH2

    		Amino Acid Derivatives Neurological Disease
    Fmoc-Ala-Glu-Gln-Lys-NH2 (AEQK) is a tetrapeptide. Fmoc-Ala-Glu-Gln-Lys-NH2 is the inactive control for Fmoc-Ala-Glu-Asn-Lys-NH2 (AENK) peptide inhibitor. AENK blocks proteolysis of UNC5C protein .
    Fmoc-Ala-Glu-Gln-Lys-NH2
  • HY-P3794
    Glu-Ala-Leu-Phe-Gln-pNA

    		Virus Protease Infection
    Glu-Ala-Leu-Phe-Gln-pNA is a Chiba virus 3C-like protease (CVP) substrate .
    Glu-Ala-Leu-Phe-Gln-pNA
  • HY-P2411
    Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH

    		Amino Acid Derivatives Others
    Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH is a dipeptide.
    Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH
  • HY-P2391
    Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH

    		Amino Acid Derivatives Others
    Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH is a dipeptide.
    Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH
  • HY-P4725
    Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2

    		Fluorescent Dye Others
    Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 is a fluorogenic substrate, that can be used for the fluorescence screening assay .
    Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2
  • HY-P4019
    Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2

    		HIV Protease Others
    Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 acts as the variable substrate in a peptidolytic assay to quantify the inhibition of the protease .
    Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
  • HY-P1324
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

    		Neuropeptide Y Receptor Neurological Disease
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake .
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
  • HY-P4331
    Boc-Gln-Gly-Arg-AMC

    		Fluorescent Dye Ser/Thr Protease Cardiovascular Disease
    Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
    Boc-Gln-Gly-Arg-AMC
  • HY-P1324A
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA

    		Neuropeptide Y Receptor Neurological Disease
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake .
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA
  • HY-134563
    Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK

    		Caspase Apoptosis Cancer
    Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK is an inhibitor for caspase-3, and inhibits Dihydroartemisinin (HY-N0176) and Dictamnine (HY-N0849) co-induced apoptosis .
    Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK
  • HY-P3307
    Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2

    		Tau Protein Neurological Disease
    Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ42.
    Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
  • HY-W101889
    Boc-Gln(Xan)-OH

    N-Boc-N'-xanthyl-L-glutamine

    		 Amino Acid Derivatives Others
    Boc-Gln(Xan)-OH (N-Boc-N'-xanthyl-L-glutamine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antigenic activity .
    Boc-Gln(Xan)-OH
  • HY-120522
    L-659877

    Cyclo(Gln-Trp-Phe-Gly-Leu-Met)

    		 Neurokinin Receptor Others
    L-659877 (Cyclo(Gln-Trp-Phe-Gly-Leu-Met)) is a compound used to study the chemical properties of peptide fragments in collision-induced dissociation. A series of experiments were conducted to study the structural changes of b-fragment ions of different lengths in collision-induced dissociation.
    L-659877
  • HY-W011391
    GPNA hydrochloride
    5+ Cited Publications

    		 Apoptosis ASCT Cancer
    GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na +-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na +-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .
    GPNA hydrochloride
  • HY-159170
    Quorum sensing-IN-7

    		Bacterial Infection
    Quorum sensing-IN-7 (compound HSL 4) is a potent quorum sensing (QS) inhibitor. Quorum sensing-IN-7 interacts with Leu 72 and Gln 95 in the CviR binding pocket. Quorum sensing-IN-7, an antibacterial agent, is highly effective at inhibiting the production of homoserine lactones (HSLs) and biofilm in C. violaceum at 0.25-1 mg/mL .
    Quorum sensing-IN-7
  • HY-P3885
    Substance P (alligator)

    		Neurokinin Receptor Endogenous Metabolite Neurological Disease
    Substance P (alligator), a Substance P (Substance P (HY-P0201)) extracted from alligator, is a neuropeptide. The primary structure of Substance P (alligator) is: Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 .
    Substance P (alligator)
  • HY-E70528
    PreScission protease

    		Biochemical Assay Reagents Others
    PreScission Protease is a recombinant protease that combines human rhinovirus (HRV) type 14 3C protease and a GST-tag. PreScission Protease can specifically recognize the short peptide Leu-Glu-Val-Leu-Phe-Gln-Gly-Pro at 4°C and cleave between Gln and Gly amino acids .
    PreScission protease
  • HY-W348072
    SARS-CoV-2-IN-59

    		SARS-CoV Infection
    SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule inhibitor of SARS-CoV-2 that targets the main protease (Mpro) of the coronavirus. SARS-CoV-2-IN-59 has a strong interaction with residues on Mpro (Met 165, Gln 166, Met 165, His 41, Gln 189) .
    SARS-CoV-2-IN-59
  • HY-E70018
    Picornain 3C

    		Endogenous Metabolite Infection Metabolic Disease
    Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses .
    Picornain 3C
  • HY-P10803
    FLDKFNHEAEDLFYQSSL

    		SARS-CoV Infection
    FLDKFNHEAEDLFYQSSL is an 18-residue peptide that binds to SARS-CoV-2 receptor-binding domain (RBD). FLDKFNHEAEDLFYQSSL inhibits the entry of SARS-Cov-2. FLDKFNHEAEDLFYQSSL also interacts with binding residues (Leu455, Phe456, Ala475 and Gln493) .
    FLDKFNHEAEDLFYQSSL
  • HY-P5380
    TNO211

    Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

    		 MMP Others
    TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)
    TNO211
  • HY-B1692
    L-Methionine-DL-sulfoximine
    2 Publications Verification

    MSX; MSO

    		 Glutaminase Neurological Disease
    L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS) .
    L-Methionine-DL-sulfoximine
  • HY-117541
    Glycyl-glutamine

    Glycyl-L-glutamine

    		 Others Neurological Disease
    Glycyl-glutamine (Glycyl-L-glutamine), as a enzymatic cleavage product of β-endorphin, is apparently an endogenous antagonist of beta-endorphin(1-31) in several systems . Glycyl-glutamine (Glycyl-L-glutamine) is an activate and stable glutamine-containing neuropeptide over glutamine (Gln) .
    Glycyl-glutamine
  • HY-162654
    FXIIIa-IN-1

    		Factor VIII Cardiovascular Disease
    FXIIIa-IN-1 (Compound 16) is a potent and selective FXIIIa (Factor XIIIa) inhibitor with an IC50 value of 2.4 μM. FXIIIa-IN-1 inhibits FXIIIa by competing with the Gln-donor protein substrate (dimethylcasein). FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants .
    FXIIIa-IN-1
  • HY-153766
    PDE5-IN-9

    		Phosphodiesterase (PDE) Cardiovascular Disease
    PDE5-IN-9 (Compound 59) is a PDE5 inhibitor (IC50: 11.2 μM). PDE5-IN-9 shows interaction with Gln 817, Tyr 612, and Ala 767 amino acid residues. PDE5-IN-9 can be used for research of cardiovascular disease .
    PDE5-IN-9
  • HY-151381
    hDHODH-IN-10

    		Dihydroorotate Dehydrogenase Cancer
    hDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer .
    hDHODH-IN-10
  • HY-P2019
    Levitide

    		Neuropeptide Y Receptor Neurological Disease
    Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus .
    Levitide
  • HY-152086
    DRP1i27

    		Dynamin Cardiovascular Disease
    DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .
    DRP1i27
  • HY-152086A
    DRP1i27 dihydrochloride

    		Dynamin Cardiovascular Disease
    DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .
    DRP1i27 dihydrochloride
  • HY-N0667
    L-Asparagine
    3 Publications Verification

    (-)-Asparagine; Asn; Asparamide

    		 Endogenous Metabolite Apoptosis DNA/RNA Synthesis Inflammation/Immunology
    L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
    L-Asparagine

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