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fluorescence polarization probe,EV-D68 2C

" in MedChemExpress (MCE) Product Catalog:

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1865

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990303

Anti-Mouse 2C TCR Antibody (1B2)	Nuclear Factor of activated T Cells (NFAT)	Others
Anti-Mouse 2C TCR Antibody (1B2) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse 2C TCR. Anti-Mouse 2C TCR Antibody (1B2) recognizes determinants on the variable regions of both the α and β subunits of the TCR (T cell receptor) expressed by the mouse cytotoxic T lymphocyte clone 2C. Anti-Mouse 2C TCR Antibody (1B2) can be used for the detections of immunofluorescence and flow cytometry .

HY-146226

Viral 2C protein inhibitor 1	Enterovirus	Infection
Viral 2C protein inhibitor 1 (compound 6aw) is a potent and broad-spectrum enterovirus antiviral agent, inhibiting viral 2C protein. Viral 2C protein inhibitor 1 inhibits multiple strains of EV-D68, EV-A71 and CVB3 with EC₅₀s of 0.1~3.6 µM, and exhibits high selectivity index and relatively low cytotoxicity .

HY-E70629

Protein phosphatase 2C	Ser/Thr Protease	Cancer
Protein phosphatase 2C is a serine-threonine phosphatase. Protein phosphatase 2C can dephosphorylate the key players of cell death pathways .

HY-N13968

Pyralomicin 2c	Antibiotic Bacterial	Infection
Pyralomicin 2c is an antibiotic with antibacterial activity .

HY-D2898

Jun14157	Fluorescent Dye Enterovirus	Infection
Jun14157 is a fluorescence polarization probe that can specifically bind to the conserved allosteric site of enterovirus 2C proteins (Ex: 485/20; Em: 528/20). Jun14157 has K_d values of 2.3 μM, 1.4 μM, and 1.1 μM for EV-D68 2C, EV-A71 2C, and CVB3 2C, respectively. Jun14157 can be used in research related to enteroviruses .

HY-172030

2C-T hydrochloride	Drug Derivative	Neurological Disease
2C-T hydrochloride is an analog of Mescaline and 2C-T-2 . Mescaline and 2C-T-2 have psychoactive effects.

HY-130394

2C-B-FLY hydrochloride	5-HT Receptor	Neurological Disease
2C-B-FLY hydrochloride is the dihydrodifuran analog of the Schedule I hallucinogen 4-bromo-2,5-dimethoxyphenethylamine (2C-B).

HY-168405

2C-iP	Drug Derivative	Neurological Disease
2C-iP is classified as a phenethylamine.

HY-124296

2C-TFM hydrochloride	5-HT Receptor	Neurological Disease
2C-TFM hydrochloride is a ,5-dimethoxyphenethylamines compound with a para-trifluoromethyl substitution. 2C-TFM hydrochloride is a potent agonist of the 5-HT receptor subtypes 5-HT2A and 5-HT2C .

HY-W722177

β-Methoxy 2C-D hydrochloride	Drug Derivative	Neurological Disease
β-Methoxy 2C-D hydrochloride is a phenethylamine.

HY-170743

β-Hydroxy 2C-B hydrochloride	Drug Derivative	Neurological Disease
β-Hydroxy 2C-B hydrochloride is a phenethylamine.

HY-159619

Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl	PROTAC Linkers	Cancer
Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl is a PROTAC Linker. Boc-azetidine-2C-oxotetrahydropyrimidin-bromophenyl can be used in the synthesis of PROTAC GSPT1 degrader-1 (HY-159609) .

HY-W753724

N-Ethyl 2C-B hydrochloride	Drug Derivative	Neurological Disease
N-Ethyl 2C-B hydrochloride is a phenethylamine with psychoactive properties .

HY-159617

Cbz-Pip-2C-Pip-C-Pip	PROTAC Linkers	Cancer
Cbz-Pip-2C-Pip-C-Pip is a PROTAC linker. Cbz-Pip-2C-Pip-C-Pip can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608) .

HY-165014

2C-I-FLY hydrochloride	Drug Derivative	Neurological Disease
2C-I-FLY hydrochloride is a phenethylamine that induces the head-twitch response in mice .

HY-W725213

α-ethyl 2C-D hydrochloride BL-3912; alpha-EH DOM	Biochemical Assay Reagents	Others
α-ethyl 2C-D (BL-3912) hydrochloride is a phenethylamine and amphetamine compound. In drug discrimination studies, α-ethyl 2C-D hydrochloride can serve as a reference standard for MDMA .

HY-168425

β-Methoxy 2C-B hydrochloride	Drug Derivative	Neurological Disease
β-Methoxy 2C-B hydrochloride is a phenethylamine. This product is intended for research and forensic applications.

HY-159620

Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl is an E3 Ligase Ligand-Linker Conjugate. Thalidomide 5-azetidine-2C-oxotetrahydropyrimidin-bromophenyl can be used to synthesize PROTAC GSPT1 degrader-1 (HY-159609) .

HY-159618

(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip	E3 Ligase Ligand-Linker Conjugates	Cancer
(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip is an E3 Ligase Ligand-Linker Conjugate. (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip can be used to synthesize PROTAC Cbl-b-IN-1 (HY-159608) .

HY-174583

Human MEF2C mRNA	mRNA	Cancer
Human MEF2C mRNA encodes the human myocyte enhancer factor 2C (MEF2C) protein, a member of the MADS box transcription enhancer factor 2 (MEF2) family. MEF2C has both trans-activating and DNA binding activities and may play a role in maintaining the differentiated state of muscle cells.

HY-174479

Mouse Mef2c mRNA	mRNA	Cardiovascular Disease
Mouse Mef2c mRNA encodes the mouse myocyte enhancer factor 2C (Mef2c) protein, a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Mef2c controls cardiac morphogenesis and myogenesis, and is also involved in vascular development, neurogenesis and the development of cortical architecture.

HY-174814

Jun15716	Enterovirus	Infection
Jun15716 is an Enterovirus (EVs) 2C protein (EVs 2C) inhibitor with K_is of 15.9, 44.2 and 17.8 μM for EV-D68, EV-A71 and CVB3, respectively. Jun15716 has a potent antiviral activity against EV-D68 US/MO/14-18947 and CVB3 Nancy cells (EC₅₀s of 1.0 and 0.7 μM, respectively). Jun15716 can be used for viral infections research, such as meningitis, hand, foot and mouth disease (HFMD) and viral myocarditis .

HY-111200

Vabicaserin hydrochloride 3 Publications Verification SCA 136	5-HT Receptor	Neurological Disease
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT_2C) receptor-selective agonist with an EC₅₀ of 8 nM.

HY-15401

WAY 163909	5-HT Receptor	Cancer
WAY 163909 is a potent and selective 5-HT(2C) receptor agonist with a K_i of 10.5±1.1 nM.

HY-155215

Tenilapine	5-HT Receptor	Others
Tenilapine displays potent inverse agonist activity at rat and human *5-HT(2C)* receptors .

HY-P99232

Indusatumab 5F9 Monoclonal antibody	Guanylate Cyclase	Cancer
Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody .

HY-130393

3C-B-FLY hydrochloride	5-HT Receptor	Neurological Disease
3C-B-FLY hydrochloride is an α-methylated analog of 2C-B-FLY.

HY-157260

Propylbenzene-(CH2)2-COOH	Others	Infection
Propylbenzene-(CH2)2-COOH (2c) is a hapten with high titer and inhibition ratio .

HY-174815

Jun15799	Enterovirus	Infection
Jun15799 is an Enterovirus (EVs) 2C protein (EVs 2C) inhibitor with K_is of 0.8, 21.1 and 3.0 μM for EV-D68, EV-A71 and CVB3, respectively. Jun15799 has a significant antiviral activity against EV-D68 US/MO/14-18947, EV-A71 Tainan/4643/1998 and CVB3 Nancy cells (EC₅₀s of 0.3, 11.4 and 0.3 μM, respectively). Jun15799 can be used for viral infections research, such as meningitis, hand, foot and mouth disease (HFMD) and viral myocarditis .

HY-118441

25T-NBOMe hydrochloride	Drug Derivative	Neurological Disease
25T-NBOMe hydrochloride is a derivative of 2C-T having an N-(2-methoxybenzyl) addition at the amine .

HY-133705

Geldanamycin-FITC	HSP	Others
Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 (Ex/Em = 488/515 nm) ^[2] .

HY-163520

IDO1-IN-24	Indoleamine 2,3-Dioxygenase (IDO)	Others
IDO1-IN-24 (compound 2c) inhibits IDO1 production in cell-based assay with an IC₅₀ value of 17 μM .

HY-163095

RH1115	Autophagy	Neurological Disease
RH1115 (compound 2c) is a modulator of the autophagy-lysosome. RH1115 induces changes to LAMP1 vesicle properties and alters lysosome positioning .

HY-138237

25I-NBMD hydrochloride	5-HT Receptor	Neurological Disease
25I-NBMD hydrochloride is a derivative of the phenethylamine 2C-I that increases the affinity and activity at the 5-HT2A receptor .

HY-124332

25T7-NBOMe hydrochloride	5-HT Receptor	Neurological Disease
25T7-NBOMe hydrochloride is a derivative of 2C-T-7, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine .

HY-120858

25T4-NBOMe hydrochloride	Drug Derivative	Neurological Disease
25T4-NBOMe hydrochloride is a derivative of 2C-T-4, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine .

HY-D1653

BDP 581/591 NHS ester	Reactive Oxygen Species (ROS)	Others
BDP 581/591 NHS ester is a a borondipyrromethene dye (Ex=585 nm, Em=594 nm) that has relatively long fluorescence lifetime and two photon excitation cross section. BDP 581/591 NHS ester can be used for fluorescence polarization analysis and also reacts with reactive oxygen species (ROS) and alter fluorescence. BDP 581/591 NHS ester is also an NHS ester derivative that can be used to bind primary and secondary amine groups of proteins, peptides and other molecules.

HY-114814

ORM-10921 free base	Adrenergic Receptor	Neurological Disease
ORM-10921 free base is a selective α-2C adrenergic receptor antagonist with a K_i of 1.4 nM. ORM-10921 free base displays potent antidepressant and antipsychotic-like effects .

HY-144697

p38 MAPK-IN-3	p38 MAPK Apoptosis Reactive Oxygen Species (ROS)	Cancer
p38 MAPK-IN-3 (Compound 2c) is a p38α MAPK inhibitor. p38 MAPK-IN-3 has antitumor activities and induces apoptosis and ROS .

HY-144722

Antitubercular agent-12	Bacterial	Infection
Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL) .

HY-10891

HIV-1 inhibitor-61	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-61 (2c) is a HIV-1 reverse transcriptase inhibitor, with an EC₅₀ of 0.07 nM in NL4-3 wt MT-4 cells .

HY-40269

L-Pyroglutamic acid ethyl ester	Biochemical Assay Reagents Drug Intermediate	Neurological Disease
L-Pyroglutamic acid ethyl ester (Compound 2c) is an intermediate. L-Pyroglutamic acid ethyl ester is involved in the synthesis of γ-aminobutyrate transaminase inactivators. L-Pyroglutamic acid ethyl ester can be used in epilepsy and Huntington's disease research .

HY-163395

3-Tosylimidazolidine-2,4-dione	Parasite	Infection
3-Tosylimidazolidine-2,4-dione (compound 2C) is a hydantoins derivative, and exhibits inhibitory activity against the Pf3D7 strain, with an IC₅₀ value of 3.97  nM .

HY-D1654

BDP 581/591 maleimide	Fluorescent Dye	Others
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.

HY-172121

NMDA agonist 2	iGluR	Neurological Disease
NMDA agonist 2 (compound 8d) is a potent agonist of NMDA receptor, with the EC₅₀ of 0.034 μM for *GluN1/2C*. NMDA agonist 2 plays an important role in neurological and psychiatric disorders .

HY-159801

E3 Ligase Ligand-linker Conjugate 122	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 122 (Compound 2c) is a conjugation of the E3 ligase ligand and the linker, and can be used for synthesis of PROTAC degrader NR-11c (HY-159798) .

HY-100734

Histone Acetyltransferase Inhibitor II 1 Publications Verification	Histone Acetyltransferase	Cancer
Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable p300 histone acetyltransferase inhibitor, with an IC₅₀ of 5 µM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells .

HY-W708033

25E-NBOMe hydrochloride	5-HT Receptor	Neurological Disease
25E-NBOMe hydrochloride is a derivative of 2C-E having an N-(2-methoxybenzyl) addition at the amine. 25E-NBOMe hydrochloride is a selective /b>5-HT2A receptor agonist.

HY-176055

hCAI/II-IN-11	Carbonic Anhydrase	Infection
hCAI/II-IN-11 (compound 2c) is a Carbonic Anhydrase Inhibitor with IC₅₀ values of 12.56 μM and 13.02 μM for hCA I and hCA II, respectively. hCAI/II-IN-11 shows antioxidant and antimicrobial effects .

HY-34887

Acridone-4-carboxylic acid	Drug Derivative	Others
Acridone-4-carboxylic acid (ACA) (Compound 2c) is a heme-interacting acridone derivatives that prevents free heme-mediated protein oxidation and degradation. Acridone-4-carboxylic acid inhibits protein carbonyl formation with an IC₅₀ of 43 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-79494

Glyoxalic acid (50% in water) 2 Publications Verification NSC 27785; Formylformic acid; Oxalaldehydic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glyoxalic acid (NSC 27785) (50% in water) is an organic compound that is both an aldehyde and a carboxylic acid. Glyoxalic acid (50% in water) induces fluorescence. Glyoxalic acid (50% in water) is used to study neurons .

HY-N0730

Diosgenin glucoside	Structural Classification Liliaceae Source classification Trillium tschonoskii Maxim. Plants Steroids	Autophagy Apoptosis
Diosgenin glucoside, a saponin compound extracted from Trillium tschonoskii, provides neuroprotection by regulating microglial M1 polarization. Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosis ^[2].

HY-N8559

Aloesone	Structural Classification Natural Products Monophenols Liliaceae Source classification Phenols Aloe vera (L.) Burm. f. Plants	Reactive Oxygen Species (ROS) Apoptosis
Aloesone is a phenolic compound. Aloesone can inhibit the production of ROS, the release of NO, M1 polarization, and apoptosis in RAW264.7 cells stimulated by LPS (HY-D1056). Aloesone has anti-inflammatory and antioxidant activities ^[2].

HY-N7043

Isosilybin A 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Flavanonols Flavonoids Glycine soya Phenols Polyphenols Disease Research Fields Cancer	Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor
Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity ^[1][2][3].

HY-N13968

Pyralomicin 2c	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic Bacterial
Pyralomicin 2c is an antibiotic with antibacterial activity .

HY-P0260

p2Ca	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Others
p2Ca, an 8-mer peptide, is a ligand that is naturally processed and presented to the Ld-alloreactive T cell clone, 2C.

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy ^[2]. Doxorubicin inhibits human DNA topoisomerase I with an IC₅₀ of 0.8 μM .

HY-N9923

2-C-Methyl-D-erythritol 4-phosphate	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Bacterial
2-C-Methyl-D-erythritol 4-phosphate is a metabolite intermediate exclusive to the non-mevalonate MEP pathway, predominantly found in prokaryotes, serving as a precursor for the synthesis of isoprenoids and non-isoprenoids, including vitamins; its absence in humans makes it a promising target for the development of bacterium-specific drugs aimed at treating infectious diseases.

HY-104026B

L-Kynurenine sulfate	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Aryl Hydrocarbon Receptor
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-N0730R

Diosgenin glucoside (Standard)	Structural Classification Liliaceae Source classification Trillium tschonoskii Maxim. Plants Steroids	Reference Standards Autophagy Apoptosis
Diosgenin glucoside (Standard) is the analytical standard of Diosgenin glucoside. This product is intended for research and analytical applications. Diosgenin glucoside, a saponin compound extracted from Trillium tschonoskii, provides neuroprotection by regulating microglial M1 polarization. Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosis ^[2].

HY-Y0836

Diethyl succinate 1 Publications Verification Diethyl Butanedioate	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Biochemical Assay Reagents Reactive Oxygen Species (ROS)
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings ^[2].

HY-B0282

Acetylcholine chloride 15+ Cited Publications ACh chloride	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	nAChR Calcium Channel Endogenous Metabolite
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) ^[2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-B0282R

Acetylcholine chloride (Standard) ACh chloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards nAChR Calcium Channel Endogenous Metabolite
Acetylcholine (chloride) (Standard) is the analytical standard of Acetylcholine (chloride). This product is intended for research and analytical applications. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) ^[2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-N7043R

Isosilybin A (Standard)	Flavanonols Structural Classification Flavonoids Glycine soya Source classification Phenols Polyphenols Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Reference Standards Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor
Isosilybin A (Standard) is the analytical standard of Isosilybin A (HY-N7043). Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting Erk and p38 signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity ^[1][2][3].

HY-N7032

Uridine 5′-diphosphoglucose disodium 5+ Cited Publications UDP-D-Glucose disodium	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite P2Y Receptor
Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

HY-113044

Uridine 5′-diphosphoglucose UDP-D-Glucose	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite P2Y Receptor
Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue ^[2] .

HY-N3205

Neochamaejasmin B (+)-Neochamaejasmin B	Flavonoids Classification of Application Fields Thymelaeaceae Source classification Stellera chamaejasme Linn. Other Diseases Phenols Polyphenols Plants Biflavones Disease Research Fields	Others
Neochamaejasmin B is a biflavanone compound. Neochamaejasmin B is isolated from Stellera chamaejasme L. (Thymelaeaceae). Neochamaejasmin B has the cis-trans geometry at the C-2/C-3 and C-2″/C-3″ positions .

HY-N16309

Cyanine 7 free acid bromide	Structural Classification Lipid	Fluorescent Dye
Cyanine 7 free acid bromide is a near-infrared fluorescent probe for labelling amine groups such as those on antibodies, nucleic acids, and proteins and can be detected using a variety of fluorescence detection techniques such as microscopy and flow cytometry.

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 558 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy ^[2] .

HY-15142R

Doxorubicin hydrochloride (Standard) 2 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy ^[2] .

HY-Y0836R

Diethyl succinate (Standard) Diethyl Butanedioate (Standard)	Structural Classification Natural Products Microorganisms other families Source classification Plants	Biochemical Assay Reagents Reference Standards Reactive Oxygen Species (ROS)
Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings ^[2].

HY-W007671R

H-Tyr-OMe (Standard)	Monophenols Source classification Phenols Amino acids Endogenous metabolite	Endogenous Metabolite Tyrosinase
H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols ^[2].

HY-W007671

H-Tyr-OMe 1 Publications Verification	Monophenols Classification of Application Fields Source classification Other Diseases Phenols Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Tyrosinase
H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols ^[2].

HY-N0131

Stigmasterol 5+ Cited Publications	Structural Classification Microorganisms Classification of Application Fields Source classification Amaranthaceae Plants Endogenous metabolite Achyranthes bidentata Inflammation/Immunology Disease Research Fields Steroids	MMP Endogenous Metabolite
Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates AMPK, which in turn inhibits NF-κB and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others ^[2] .

HY-N0688

Linderane	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm. Inflammation/Immunology Disease Research Fields	Cytochrome P450
Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp .

HY-N0145R

Puerarin (Standard)	Structural Classification Flavonoids Pueraria edulis Pampan. Leguminosae Source classification Phenols Polyphenols Plants Isoflavones	Reference Standards 5-HT Receptor
Puerarin (Standard) is the analytical standard of Puerarin. This product is intended for research and analytical applications. Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.

HY-N1347

Robinetin 3,3',4',5',7-Pentahydroxyflavone	Infection Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Fungal HIV Integrase Bacterial
Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation ^[2] .

HY-17038A

Agomelatine hydrochloride 4 Publications Verification S-20098 hydrochloride	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and *MT2* receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pK_is of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively ^[2].

HY-17038

Agomelatine 4 Publications Verification S-20098	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine (S-20098) is a specific agonist of MT1 and *MT2* receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pK_is of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively ^[2].

HY-N2909

Aurantiamide	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	NF-κB RIP kinase Mixed Lineage Kinase
Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models ^[2] .

HY-113044R

Uridine 5′-diphosphoglucose (Standard) UDP-D-Glucose (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite P2Y Receptor
Uridine 5′-diphosphoglucose (Standard) (UDP-D-Glucose (Standard)) is the analytical standard of Uridine 5′-diphosphoglucose (HY-113044). This product is intended for research and analytical applications. Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory *P2Y14* receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

HY-17038B

Agomelatine (L(+)-Tartaric acid) 4 Publications Verification S-20098 L(+)-Tartaric acid	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and *MT2* receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine L(+)-Tartaric acid is a selective 5-HT2C receptor antagonist with pK_is of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively ^[2].

HY-N16316

Meso-Cl cyanine 7 free acid chloride	Structural Classification Lipid	Fluorescent Dye
Meso-Cl cyanine 7 free acid chloride is a Meso-Cl cyanine fluorescent dye. Meso-Cl cyanine 7 free acid chloride can be used for labelling amine groups such as those on antibodies, nucleic acids, and proteins and can be detected using a variety of fluorescence detection techniques such as microscopy and flow cytometry (Ex/Em = 778/805 nm) .

HY-17038R

Agomelatine (Standard) S-20098 (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Endogenous metabolite	Reference Standards Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine (Standard) is the analytical standard of Agomelatine. This product is intended for research and analytical applications. Agomelatine (S-20098) is a specific agonist of MT1 and *MT2* receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pK_is of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively ^[2].

HY-17038AR

Agomelatine hydrochloride (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Endogenous metabolite	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine (hydrochloride) (Standard) is the analytical standard of Agomelatine (hydrochloride). This product is intended for research and analytical applications. Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively ^[2].

HY-N8200

Cassiaside B2	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Inflammation/Immunology Disease Research Fields	Phosphatase Monoamine Oxidase 5-HT Receptor
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a *5-HT2C* receptor agonist ^[2]. ..

HY-N16307

Meso-Cl cyanine 7.5 free acid chloride	Structural Classification Lipid	Fluorescent Dye
Meso-Cl cyanine 7.5 free acid chloride is a Meso-Cl cyanine fluorescent dye. Meso-Cl cyanine 7.5 free acid chloride can be used for labelling amine groups such as those on antibodies, nucleic acids, and proteins and can be detected using a variety of fluorescence detection techniques such as microscopy and flow cytometry (Ex/Em = 815/825 nm) .

HY-N0688R

Linderane (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Reference Standards Cytochrome P450
Linderane (Standard) is the analytical standard of Linderane. This product is intended for research and analytical applications. Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp .

HY-N0145

Puerarin 20+ Cited Publications	Structural Classification Flavonoids Pueraria edulis Pampan. Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	5-HT Receptor
Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which in turn leads to decreased fat absorption ^[2] .

HY-N1347R

Robinetin (Standard) 3,3',4',5',7-Pentahydroxyflavone (Standard)	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	Reference Standards Fungal HIV Integrase Bacterial
Robinetin (Standard) is the analytical standard of Robinetin. This product is intended for research and analytical applications. Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation ^[2] .

HY-W040821R

DL-Homocysteine (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Reference Standards Endogenous Metabolite
Metoprolol acid (Standard) is the analytical standard of Metoprolol acid. This product is intended for research and analytical applications. Metoprolol acid (Atenolol acid) is a urinary metabolite with no pharmacological activity. Metoprolol acid does not exert its pharmacological effects in vivo. Metoprolol acid can be detected by solid phase extraction and reversed phase high performance liquid chromatography. The analysis of metoprolol acid requires specific conditions, such as the use of fluorescence detection and specific eluents .

HY-N0319

Salvianolic acid C 4 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Cytochrome P450
Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with K_is of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-W008772

4-Hydroxymephenytoin	Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Drug Metabolite
4-Hydroxymephenytoin is a metabolism of an antiepileptic agent mephenytoin, which is used as a CYP2C19 substrate.

HY-N1201

Apigenin 30+ Cited Publications 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1	Structural Classification Classification of Application Fields Flavones Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Umbelliferae Baccharis sarothroides A.Gray Disease Research Fields Cancer	Autophagy Cytochrome P450 Endogenous Metabolite
Apigenin (4',5,7-Trihydroxyflavone) is a competitive *CYP2C9* inhibitor with a K_i of 2 μM.

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species (ROS) PPAR
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and *Bcl-2* related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses ^[2] .

HY-N6023

Thermopsoside	Flavonoids Classification of Application Fields Flavones Astragalus microcephalus Willd. Source classification Other Diseases Phenols Polyphenols Plants Compositae Disease Research Fields	Cytochrome P450
Thermopsoside is a flavone derivative isolated from Aspalathus linearis. Thermopsoside exhibits inhibitory effects on CYP450 isozymes with IC₅₀ values of 6.0 μM, 9.5 μM, 12.0 μM, 32.0 μM, for CYP3A4, CYP2C19, CYP2D6 and CYP2C9, respectively .

HY-N10869

Pseudolaric acid C2-O-β-D-glucoside	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Pseudolarix amabilis (J. Nelson) Rehder Plants	Others
Pseudolaric acid C2-O-β-D-glucoside is a natural product isolated from Pseudolarix kaempferi .

HY-N0893

Tetrahydrocurcumin 2 Publications Verification HZIV 81-2	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Microorganisms Phenols Polyphenols Curcuma longa Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	Cytochrome P450 Autophagy Endogenous Metabolite
Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit *CYP2C9* and CYP3A4.

HY-N0319R

Salvianolic acid C (Standard)	Structural Classification Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Plants	Reference Standards Cytochrome P450
Salvianolic acid C (Standard) is the analytical standard of Salvianolic acid C. This product is intended for research and analytical applications. Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-165424

NIR-BG2	Structural Classification Alkaloids Other Alkaloids Cananga odorata Source classification Plants Annonaceae Indole Alkaloids	Fluorescent Dye Glycosidase
NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence ^[2].

Cat. No.	Product Name	Chemical Structure

HY-14541S

Olanzapine-d3
Olanzapine-d₃ is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic ^[2].

HY-104026CS

L-Kynurenine-13C10 sulfate hemihydrate
L-Kynurenine- ¹³C10 (sulfate hemihydrate) is the ¹³C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype ^[2].

HY-142140S

3-epi-25-Hydroxy Vitamin D3-d6
3-epi-25-Hydroxy Vitamin D3-d₆ is the deuterium labeled 3-epi-25-Hydroxy Vitamin D3 (HY-142140) . 3-epi-25-Hydroxy Vitamin D3 is the vitamin D metabolite, while vitamin D metabolism highly dependent on macrophage polarization. The C3-epimerase pathway for vitamin D is active in macrophages ^[2].

HY-B0258S

Gemfibrozil-d6
Gemfibrozil-d₆ is the deuterium labeled Gemfibrozil. Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

HY-16567S

Asenapine-13C,d3 hydrochloride
Asenapine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Asenapine (hydrochloride). Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-14541S2

Olanzapine-d8

Olanzapine-d8 is a deuterated labeled Olanzapine . Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic ^[2] .

HY-W090625S

*5H-Benzofuro[3,2-c]carbazole-d10*
5H-Benzofuro[3,2-c]carbazole-d₁₀ is the deuterium labeled 5H-Benzofuro[3,2-c]carbazole (HY-W090625) .

HY-40171S

NH2-C2-NH-Boc-d4
NH2-C2-NH-Boc-d₄ is the deuterium labeled NH2-C2-NH-Boc . NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs ^[2].

HY-104026BS

L-Kynurenine-13C10 sulfate
L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype ^[2].

HY-124891S

1-Phenylpyrrole-d9
1-Phenylpyrrole-d9 (N-Phenylpyrrole-d9) is the deuterium labeled 1-Phenylpyrrole (HY-124891). 1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents .

HY-10285S1

(rel)-Saxagliptin-13C,d2 TFA
(rel)-Saxagliptin- ¹³C,d₂ ((rel)-BMS-477118- ¹³C,d₂) TFA is ¹³C-labeled Saxagliptin (HY-10285) .

HY-17038S1

Agomelatine-d4
Agomelatine-d₄ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively ^[2].

HY-17038S2

Agomelatine-d3
Agomelatine-d₃ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively ^[2].

HY-176436S

GW-117
GW-117 is a 5-HT2C receptor antagonist and a melatonin (MT1/MT2) receptor agonist. GW-117 shows antidepressant-like and anxiolytic-like effects .

HY-B0258S1

Gemfibrozil-d6-1
Gemfibrozil-d6-1 (CI-719-d6-1) is the deuterium labeled Gemfibrozil (HY-B0258). Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with K_i values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively .

HY-17356S

Fenofibrate-d6
Fenofibrate-d₆ is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

HY-133111S

3-Hydroxy agomelatine-d3
3-Hydroxy agomelatine-d₃ is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC₅₀ of 3.2 μM and a K_i of 1.8 μM .

HY-17356S2

Fenofibrate-13C6
Fenofibrate-13C6 is a deuterated labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for *CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4*, respectively.

HY-17356S1

Fenofibrate-d4
Fenofibrate-d₄ is the deuterium labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively ^[2] .

HY-B1449S3

Uridine-13C-2
Uridine- ¹³C-2 is the ¹³C labeled Uridine .

HY-N7032S

Uridine 5′-diphosphoglucose-13C disodium

Uridine 5′-diphosphoglucose- ¹³C (UDP-D-Glucose- ¹³C) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue ^[2] .

HY-N7032S1

Uridine 5′-diphosphoglucose-13C6 disodium

Uridine 5′-diphosphoglucose- ¹³C₆ (UDP-D-Glucose- ¹³C₆) disodium is the ¹³C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue ^[2] .

HY-I0400S2

N-Acetylneuraminic acid-13C-2
N-Acetylneuraminic acid- ¹³C-2 is the ¹³C labeled N-Acetylneuraminic acid.

HY-100641S

4-Hydroxytolbutamide-d9
4-Hydroxytolbutamide-d₉ is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic ^[2].

HY-144198S

Saxagliptin-13C,d2 hydrochloride
Saxagliptin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Saxagliptin .

HY-146994S2

L-Idose-13C-2
L-Idose- ¹³C-2 is the ¹³C labeled L-Idose .

HY-W011240S

Hydroflumethiazide-13C,d2
Hydroflumethiazide- ¹³C,d₂ is the deuterium and ¹³C labeled Hydroflumethiazide .

HY-W777166

Aprepitant-13C2,d2 (Major)
Aprepitant- ¹³C₂,d₂ (Major) (MK-0869- ¹³C₂,d₂) is ¹³C labeled Aprepitant. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K_d of 86 pM.

HY-77956S2

Thyminose-13C-2
Thyminose- ¹³C-2 is the ¹³C labeled Thyminose. Thyminose is an endogenous metabolite .

HY-W777877

Carbovir-13C,d2
Carbovir- ¹³C,d₂ is the deuterium labeled and ¹³C-labeled Carbovir.

HY-N0378S6

D-Mannitol-13C,d2
D-Mannitol- ¹³C,d₂ is the deuterium and ¹³C labeled D-Mannitol.

HY-B0214S3

Prednisone-13C2,d2
Prednisone- ¹³C₂,d₂ (Dehydrocortisone- ¹³C₂,d₂) is ¹³C labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus ^[2].

HY-W338294S1

2'-Deoxycytidine-13C-2 monohydrate
2'-Deoxycytidine- ¹³C-2 (monohydrate) Monohydrate is the ¹³C labeled 2'-Deoxycytidine .

HY-15550S

4'-Hydroxy diclofenac-d4
4'-Hydroxy diclofenac-d₄ is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties ^[2].

HY-B0781S

Promethazine-d4 hydrochloride
Promethazine-d₄ (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

HY-14264S

Cyamemazine-d6
Cyamemazine-d₆ is the deuterium labeled Cyamemazine. Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity ^[2].

HY-15550S1

4'-Hydroxy diclofenac-13C6
4'-Hydroxy diclofenac- ¹³C₆ is the ¹³C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties ^[2] .

HY-128753S3

D-Lyxose-13C-2
D-Lyxose- ¹³C-2 is the ¹³C labeled D-Lyxose. D-Lyxose is an endogenous metabolite .

HY-W005355S7

Sodium 2-oxobutanoate-13C,d2
Sodium 2-oxobutanoate- ¹³C,d₂ is the deuterium and ¹³C labeled Sodium 2-oxobutanoate .

HY-W777577

ent-Calindol Hydrochloride-13C,d2
ent-Calindol Hydrochloride- ¹³C,d₂ is the deuterium and ¹³C labeled (S)-Calindol hydrochloride (HY-122819A).

HY-A0118S1

Naloxegol-13C,d2
Naloxegol- ¹³C,d₂ (NKTR-118- ¹³C,d₂) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation ^[2].

HY-B0781S1

Promethazine-d3 hydrochloride

Promethazine-d₃ (hydrochloride) is deuterium labeled Promethazine (hydrochloride). Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors ^[2].

HY-W011240S1

Hydroflumethiazide-15N2,13C,d2
Hydroflumethiazide- ¹⁵N₂, ¹³C,d₂ is the ¹³C- and ¹⁵N-labeled Hydroflumethiazide .

HY-157077S

5-Hydroxysaxagliptin-13C,d2 TFA
5-Hydroxysaxagliptin- ¹³C,d₂ (TFA) is ¹³C-labeled 5-Hydroxysaxagliptin .

HY-B1184S1

Mephenytoin-d5
Mephenytoin-d₅ is the deuterium labeled Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate .

HY-126857AS1

5-Hydroxyomeprazole-13C,d2 sodium
5-Hydroxyomeprazole- ¹³C,d₂ sodium is ¹³C and deuterated labeled 5-Hydroxyomeprazole sodium (HY-126857A).

HY-Y0781S3

Pyruvic acid-13C-2 sodium
Pyruvic acid- ¹³C-2 (sodium) is the ¹³C labeled Pyruvic acid . Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats ^[2].

HY-144199S

5-Hydroxy Saxagliptin-13C,d2 hydrochloride
5-Hydroxy Saxagliptin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled 5-Hydroxy Saxagliptin .

HY-W005355S

Sodium 2-oxobutanoate-13C4,d2 hydrate
Sodium 2-oxobutanoate- ¹³C₄,d₂ (hydrate) is the deuterium and ¹³C labeled Sodium 2-oxobutanoate hydrate .

HY-B1184S2

Mephenytoin-d8
Mephenytoin-d₈ is the deuterium labeled Mephenytoin . Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate ^[2].

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