2. Neuronal Signaling
  3. Amyloid-β
  4. Pittsburgh Compound B

Pittsburgh Compound B  (Synonyms: PiB; 6-OH-BTA-1)

Cat. No.: HY-126192 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research.

For research use only. We do not sell to patients.

Pittsburgh Compound B

Pittsburgh Compound B Chemical Structure

CAS No. : 566169-93-5

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Pittsburgh Compound B Related Antibodies

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Description

Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research[1].

Clinical Trial
Molecular Weight

256.33

Formula

C14H12N2OS
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

OC1=CC=C2N=C(SC2=C1)C3=CC=C(C=C3)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (195.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9012 mL 19.5061 mL 39.0122 mL
5 mM 0.7802 mL 3.9012 mL 7.8024 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (245 KB) HNMR (114 KB) MS (191 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9012 mL 19.5061 mL 39.0122 mL 97.5305 mL
5 mM 0.7802 mL 3.9012 mL 7.8024 mL 19.5061 mL
10 mM 0.3901 mL 1.9506 mL 3.9012 mL 9.7531 mL
15 mM 0.2601 mL 1.3004 mL 2.6008 mL 6.5020 mL
20 mM 0.1951 mL 0.9753 mL 1.9506 mL 4.8765 mL
25 mM 0.1560 mL 0.7802 mL 1.5605 mL 3.9012 mL
30 mM 0.1300 mL 0.6502 mL 1.3004 mL 3.2510 mL
40 mM 0.0975 mL 0.4877 mL 0.9753 mL 2.4383 mL
50 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9506 mL
60 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6255 mL
80 mM 0.0488 mL 0.2438 mL 0.4877 mL 1.2191 mL
100 mM 0.0390 mL 0.1951 mL 0.3901 mL 0.9753 mL
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Pittsburgh Compound B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pittsburgh Compound B566169-93-5PiB 6-OH-BTA-1Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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