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  5. AGO3 Antibody (YA3124)

AGO3 Antibody (YA3124)

Cat. No.: HY-P83379
User Guide for Antibodies Technical Support

AGO3 Antibody (YA3124) is a non-conjugated IgG antibody, targeting AGO3, with a predicted molecular weight of 97 kDa (observed band size: 97 kDa). AGO3 Antibody (YA3124) can be used for WB experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

AGO3 Antibody (YA3124) is a non-conjugated IgG antibody, targeting AGO3, with a predicted molecular weight of 97 kDa (observed band size: 97 kDa). AGO3 Antibody (YA3124) can be used for WB experiment in human, mouse, rat background.
Background

AGO3, an integral player in RNA-mediated gene silencing (RNAi), exerts its regulatory role by binding to short RNAs, including microRNAs (miRNAs), and effectively repressing the translation of mRNAs that bear complementary sequences. Its involvement extends to the stabilization of small RNA derivatives, particularly small interfering RNAs (siRNAs), originating from processed RNA polymerase III-transcribed Alu repeats that harbor a DR2 retinoic acid response element (RARE) in stem cells. AGO3 is proposed to orchestrate the subsequent siRNA-dependent degradation of a specific subset of RNA polymerase II-transcribed coding mRNAs by recruiting an mRNA decapping complex, which includes EDC4. While possessing RNA slicer activity, AGO3 exhibits this cleavage function selectively, targeting RNAs with distinct 5'- and 3'-flanking sequences within the region of guide-target complementarity.
Gene ID
SwissProt ID
Synonyms
EIF2C3; Argonaute3; Argonaute 3; AGO3; EIF-2C 3; HAgo3; EIF2C 3; Protein argonaute-3
Molecular Weight

Predicted band size: 97 kDa; Observed band size: 97 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human EIF2C3
Database

Entrez Gene: 192669 Human ; 214150 Mouse ; 313593 Rat

SwissProt: Q9H9G7 Human ; Q8CJF9 Mouse ;

OMIM: 607355 Human

Documentation
User Guide for Antibodies (1077 KB)

AGO3 Antibody (YA3124) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AGO3 Antibody (YA3124)
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