PRK2 Antibody (YA5026)

PRK2 Antibody (YA5026) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PRK2. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, monkey.

PRK2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein involved in specific cellular signal transduction responses. It regulates cell cycle progression, actin cytoskeleton assembly, cell migration, adhesion, tumor invasion, and transcriptional activation. PRK2 phosphorylates CTTN in hyaluronan-induced astrocytes, reducing CTTN's F-actin binding capacity, and HDAC5 to impair its nuclear import. As a direct RhoA target, it mediates primordial-to-apical junction maturation in bronchial epithelial cells. It facilitates G2/M phase progression and cytokinesis abscission via ECT2, stimulates FYN kinase activity for keratinocyte adhesion, and modulates bladder epithelial cell migration direction/speed during tumor invasion. PRK2 inhibits Akt pro-survival signaling, mediates Rho-induced transcription via c-fos SRF, and negatively regulates ciliogenesis. by similar: During microbial infection, it phosphorylates HCV NS5B to enhance HCV RNA replication.

Q16513

Predicted band size: 112 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat, Monkey

WB: 1:500-1:2000; IHC: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human PRK2 expressed in E. Coli.