Uridine 5′-diphosphoglucose (Synonyms: UDP-D-Glucose)

Cat. No.: HY-113044: Data Sheet Handling Instructions
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Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Uridine 5′-diphosphoglucose disodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Uridine 5′-diphosphoglucose Chemical Structure

CAS No. : 133-89-1

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
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Other Forms of Uridine 5′-diphosphoglucose:

Uridine 5′-diphosphoglucose-¹³C₆ disodium In-stock
Uridine 5′-diphosphoglucose disodium In-stock
Uridine 5′-diphosphoglucose (Standard) In-stock
Uridine 5′-diphosphoglucose-¹³C disodium Get quote
Uridine 5′-diphosphoglucose disodium dihydrate Get quote

5 Publications Citing Use of MCE Uridine 5′-diphosphoglucose

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P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Human Endogenous Metabolite

P2Y14 Receptor

Microbial Metabolite

In Vitro

Uridine 5’-diphosphoglucose (0-100 μM, 24 h) upregulates the expression of P2Y14 receptor, which induces neutrophil apoptos^[2].
Uridine 5’-diphosphoglucose (1 μM, 24 h) and PPTN (HY-110322A) result in suppressed mRNA level of inflammatory factors including CCL3, IL1β,IL12a, TNF-α in neutrophils compared to cells treated with Uridine 5’-diphosphoglucose disodium salt alone, on the contrary, anti-inflammatory factors including IL10, TGF-β1, YM1 are upregulated upon Uridine 5’-diphosphoglucose disodium salt and PPTN (HY-110322A) in neutrophils^[2].
Depletion of the pools of uridine 5’-diphosphoglucose (5 or 20 mM, incubation for 3 h) in the liver of the rat was associated with decreased glycosylation of secreted and tissue glycoproteins, influencing the rate of glomerular basement membrane (GBM) synthesis in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Neutrophils
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Decreased cell viability and elevated apoptosis of neutrophils, which was blunted by PPTN (HY-110322A).

Cell Migration Assay ^[2]

Cell Line:	Neutrophils
Concentration:	1 μM
Incubation Time:	24 h
Result:	Resulted in impaired neutrophil migration, which was inverted by PPTN (HY-110322A).

Molecular Weight

566.30

Formula

C₁₅H₂₄N₂O₁₇P₂

CAS No.

133-89-1

SMILES

O[C@@H]1[C@H](O)[C@@H](COP(O)(OP(O)(O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)=O)=O)O[C@H]1N3C=CC(NC3=O)=O

Structure Classification

Others

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.

[2]. Li K, et al. Upregulation of P2Y14 receptor in neutrophils promotes inflammation after myocardial ischemia/reperfusion injury[J]. Life Sci. 2023 Aug 1;326:121805. [Content Brief]

[3]. Cortes P, Dumler F, Levin NW. De novo pyrimidine nucleotide biosynthesis in isolated rat glomerul[J]i. Kidney Int. 1986 Jul;30(1):27-34. [Content Brief]

[4]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. [Content Brief]

Uridine 5′-diphosphoglucose Related Classifications

Metabolic Disease Inflammation/Immunology Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine 5′-diphosphoglucose133-89-1UDP-D-GlucoseEndogenous MetaboliteP2Y ReceptorUridine5′-diphosphoglucosedisodiumendogenousmetaboliteP2YreceptorInhibitorinhibitorinhibit

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