2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. GS-6620 PM

GS-6620 PM  (Synonyms: 1'-Cyano-2'-C-methyl 4-aza-7,9-dideaza adenosine)

Cat. No.: HY-177020
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GS-6620 PM (Compound 2) is an analog of 2′-C-methyl 4-aza-7,9-dideaza adenosine. 2′-C-methyl 4-aza-7,9-dideaza adenosine is an inhibitor of HCV replication in cell culture. GS-6620 PM can be used in the study of hepatitis C virus (HCV) infection.

For research use only. We do not sell to patients.

GS-6620 PM

GS-6620 PM Chemical Structure

CAS No. : 1191237-49-6

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GS-6620 PM Related Antibodies

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Description

GS-6620 PM (Compound 2) is an analog of 2′-C-methyl 4-aza-7,9-dideaza adenosine. 2′-C-methyl 4-aza-7,9-dideaza adenosine is an inhibitor of HCV replication in cell culture. GS-6620 PM can be used in the study of hepatitis C virus (HCV) infection[1].

Cellular Effect
Cell Line Type Value Description References
HEp-2 CC50
> 100 μM
Compound: 10
Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 4 to 5 days by CellTiter Glo viability assay
Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 4 to 5 days by CellTiter Glo viability assay
[PMID: 33835812]
HEp-2 CC50
> 100 μM
Compound: 13
Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
[PMID: 28124907]
HEp-2 EC50
> 100 μM
Compound: 10
Antiviral activity against RSV A2 infected in HEp-2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by CellTiter Glo viability assay
Antiviral activity against RSV A2 infected in HEp-2 cells assessed as reduction in virus-induced cytopathic effect after 4 days by CellTiter Glo viability assay
[PMID: 33835812]
HeLa EC50
50 μM
Compound: 13
Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay
[PMID: 28124907]
Huh-7 CC50
> 44 μM
Compound: 13
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 3 days by calcein-AM dye based fluorescence assay
[PMID: 28124907]
Huh-7 CC50
> 89 μM
Compound: 10
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 3 days by dual-Glo luciferase assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 3 days by dual-Glo luciferase assay
[PMID: 33835812]
Huh-7 EC50
> 89 μM
Compound: 2
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay
[PMID: 23547794]
MT4 CC50
> 200 μM
Compound: 10
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by CellTiter Glo viability assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by CellTiter Glo viability assay
[PMID: 33835812]
MT4 CC50
> 57 μM
Compound: 13
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay
[PMID: 28124907]
Molecular Weight

305.29

Formula

C13H15N5O4
CAS No.
SMILES

NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@@](O)(C)[C@H](O)[C@@H](CO)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GS-6620 PM Related Classifications

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  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-6620 PM1191237-49-61'-Cyano-2'-C-methyl 4-aza-7,9-dideaza adenosineNucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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