CY5.5-COOH chloride  (Synonyms: Cyanine 5.5 carboxylic acid chloride)

Cy5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH chloride possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH chloride can be used for bioimaging and disease diagnosis^[1].

Brief steps for labeling polypropylene (PP) microplastics with Cy5.5-COOH chloride for bioimaging^[1]:
1. Labeling PP microplastics: Mix PP microplastics with tetrahydrofuran and distilled water, add Cy5.5-COOH chloride solution in DMSO, stir for 4 days, then filter, wash, and dry.
2. Verifying labeling efficiency: Confirm particle size and morphology via SEM and PSA, validate chemical structure by FT-IR, and detect fluorescence intensity using IVIS imaging.
3. Stability tests: Evaluate fluorescence stability in corn oil and digestive stability in simulated gastrointestinal fluids.
4. Biodistribution study: After oral administration of Cy-PP to mice, monitor real-time in vivo distribution at different time points via IVIS, and detect fluorescence signals in organs and feces at 24 hours.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

619.23

C₄₀H₄₃ClN₂O₂

2410537-32-3

C[N+]1=C(/C=C/C=C/C=C2N(CCCCCC(O)=O)C3=C(C4=CC=CC=C4C=C3)C/2(C)C)C(C)(C)C5=C1C=CC6=CC=CC=C56.[Cl-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sijoon Lee, et al. Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice. Int J Mol Sci. 2023 May 9;24(10):8463.  [Content Brief]