2. Anti-infection
  3. VSV
  4. SMU-V18

SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor, with an EC50 of 6.2 μM. SMU-V18 inhibits VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with early viral infection stages, also effective against wild-type VSV (VSV-WT). SMU-V18 inhibits VSV-GFP in mouse tissues and prolongs survival. SMU-V18 can be used for the study of vesicular stomatitis virus (VSV) infection.

For research use only. We do not sell to patients.

SMU-V18

SMU-V18 Chemical Structure

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SMU-V18 Related Antibodies

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Description

SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor, with an EC50 of 6.2 μM. SMU-V18 inhibits VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with early viral infection stages, also effective against wild-type VSV (VSV-WT). SMU-V18 inhibits VSV-GFP in mouse tissues and prolongs survival. SMU-V18 can be used for the study of vesicular stomatitis virus (VSV) infection[1].

In Vitro

SMU-V18 (1.2-40 μM, 24 h) significantly inhibits VSV-GFP replication (EC50 = 6.2 μM) in HeLa cells, reduces GFP fluorescence intensity, VSV-P mRNA, and GFP expression[1].
SMU-V18 (5-20 μM, 24 h) effectively suppresses progeny VSV-GFP release[1].
SMU-V18 (5-20 μM, 6-24 h) significantly inhibits VSV-WT replication in Vero cells and reduces VSV-WT plaque formation and decreases viral mRNA levels under different MOIs and incubation times[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMU-V18 Related Antibodies

Real Time qPCR[1]

Cell Line: HeLa cells
Concentration: 5, 10, 20, 40 μM
Incubation Time: 6, 12, 24 h
Result: Reduced the VSV-P mRNA levels.
In Vivo

SMU-V18 (25-50 mg/kg, i.p., once daily, 5 days) significantly reduces VSV-GFP replication in mouse tissues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: VSV-GFP (5×107 PFU) was intraperitoneally injected into 6-week-old male BALB/c mice to establish a VSV infection animal model[1]
Dosage: 25 mg/kg, 50 mg/kg
Administration: i.p., once daily, 5 days
Result: Achieved significant inhibition of VSV-GFP replication in multiple tissues (intestine, liver, kidney, brain) of infected mice.
Showed no severe weight loss (body weight decreased initially then gradually recovered) and significantly improved survival rate.
Reduced VSV-induced splenomegaly, with a significant decrease in the spleen index.
Appeared reduced progeny VSV replication in mouse serum.
Showed alleviation of VSV-GFP-induced pathological damage in multiple organs (heart, lung, intestine), restoring myocardial fiber order, improving alveolar structure, and maintaining intestinal villus integrity .
Molecular Weight

387.31

Formula

C19H12F3N3O3
SMILES

O=C(C1=NC(C2=CC=C3OCCOC3=C2)=NC=C1)NC4=CC(F)=C(F)C(F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMU-V18 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMU-V18VSVVesicular Stomatitis VirusInhibitorinhibitorinhibit

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