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Results for "

1b

" in MedChemExpress (MCE) Product Catalog:

895

Inhibitors & Agonists

2

Fluorescent Dye

7

Biochemical Assay Reagents

33

Peptides

22

Inhibitory Antibodies

77

Natural
Products

243

Recombinant Proteins

52

Isotope-Labeled Compounds

177

Antibodies

3

Click Chemistry

231

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158301
    MY-1B
    1 Publications Verification

    		 DNA Methyltransferase RNA MTase Others
    MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes [1] .
    MY-1B
  • HY-137584
    1a,1b-Dihomo prostaglandin E1

    1a,1b-Dihomo PGE1

    		 Prostaglandin Receptor Endocrinology
    1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is a class of prostaglandin compound [1].
    1a,1b-Dihomo prostaglandin E1
  • HY-N10683
    1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran

    		Others Others
    1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran is a sesquiterpenoid isolated from the root bark of Tripterygium hypoglaucum containing a benzoyl and a cinnamoyl group [1].
    1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran
  • HY-154130
    1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil

    		Nucleoside Antimetabolite/Analog Cancer
    1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
    1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil
  • HY-154129
    1-(b-D-Xylofuranosyl)-5-methoxyuracil

    		Nucleoside Antimetabolite/Analog Cancer
    1-(b-D-Xylofuranosyl)-5-methoxyuracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
    1-(b-D-Xylofuranosyl)-5-methoxyuracil
  • HY-154128
    1-(b-D-Xylofuranosyl)-5-fluorouracil

    		Nucleoside Antimetabolite/Analog Cancer
    1-(b-D-Xylofuranosyl)-5-fluorouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
    1-(b-D-Xylofuranosyl)-5-fluorouracil
  • HY-154132
    1-(b-D-Xylofuranosyl)-N6-(p-methoxybenzyl) adenine

    		Nucleoside Antimetabolite/Analog Cancer
    1-(b-D-Xylofuranosyl)-N6-(p-methoxybenzyl) adenine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
    1-(b-D-Xylofuranosyl)-N6-(p-methoxybenzyl) adenine
  • HY-W766078
    1-beta-D-Arabinofuranosyluracil-13C,15N2

    1-b-D-Arabinofuranosyluracil-13C,15N2; Uracil 1-β-D-arabinofuranoside-13C,15N2

    		 Isotope-Labeled Compounds Infection Cardiovascular Disease Cancer
    1-beta-D-Arabinofuranosyluracil- 13C, 15N2 (1-b-D-Arabinofuranosyluracil- 13C, 15N2; Uracil 1-β-D-arabinofuranoside- 13C, 15N2) is the 13C- and 15N-labeled labeled 1-beta-D-Arabinofuranosyluracil (HY-N6652). 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties [1]. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
    1-beta-D-Arabinofuranosyluracil-13C,15N2
  • HY-N13947
    Pyralomicin 1b

    		Antibiotic Bacterial Infection
    Pyralomicin 1b is an antibiotic with antibacterial activity [1].
    Pyralomicin 1b
  • HY-N14584
    Roselipin 1B

    		Acyltransferase Infection
    Roselipin 1B inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm [1].
    Roselipin 1B
  • HY-P99139
    Anti-Mouse IL-1b Antibody (B122)

    		Interleukin Related Reactive Oxygen Species (ROS) Ferroptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Anti-Mouse IL-1b Antibody (B122) is an anti-mouse IL-1b IgG monoclonal antibody. Anti-Mouse IL-1b Antibody (B122) enhances ferroptosis and increases levels of reactive oxygen species (ROS) combinated with Sulfasalazine (SAS) (HY-14655). Anti-Mouse IL-1b Antibody (B122) can reduce monocyte infiltration and alleviate T cell exhaustion by blocking IL-1β signaling. Anti-Mouse IL-1b Antibody (B122) can be used for research on cancer and cardiovascular conditions such as oral squamous cell carcinoma (OSCC), glioblastoma (GBM) and heart failure [1] .
    Anti-Mouse IL-1b Antibody (B122)
  • HY-131632
    1a,1b-Dihomo prostaglandin F2α

    1a,1b-Dihomo-PGF2α

    		 Endogenous Metabolite Others
    1a,1b-Dihomo prostaglandin F2α (1a,1b-Dihomo-PGF2α) is the derivative of Prostaglandin F2α (HY-12956) [1].
    1a,1b-Dihomo prostaglandin F2α
  • HY-100462
    PTP1B-IN-2
    3 Publications Verification

    		 Phosphatase Metabolic Disease
    PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
    PTP1B-IN-2
  • HY-162480
    PTP1B-IN-27

    		Glycosidase Phosphatase Endocrinology
    PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC50=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC50=120 µM) and shows competitive inhibition (Ki=118 µM) [1].
    PTP1B-IN-27
  • HY-144062
    INSCoV-614(1B)

    		SARS-CoV Infection
    INSCoV-614(1B) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-614(1B) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) [1].
    INSCoV-614(1B)
  • HY-162479
    PTP1B-IN-26

    		Phosphatase Amyloid-β Metabolic Disease
    PTP1B-IN-26 (Compound 7a) is a derivative of phenylthiosemicarbazide‐phenoxy‐1,2,3‐triazole‐N‐phenylacetamide. PTP1B-IN-26 is an inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP1B-IN-26 is a competitive inhibitor. PTP1B-IN-26 can be used to research in type 2 diabetes [1].
    PTP1B-IN-26
  • HY-N1111
    Uncaric acid

    6β,19α-Dihydroxyursolic acid

    		 HIV Infection
    Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity [1].
    Uncaric acid
  • HY-136267
    HCV-IN-30

    		HCV Infection
    HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively [1].
    HCV-IN-30
  • HY-131626
    1a,1b-Dihomo prostaglandin E2

    1a,1b-Dihomo PGE2

    		 COX Metabolic Disease
    1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
    1a,1b-Dihomo prostaglandin E2
  • HY-108196
    PTP1B-IN-15

    		Phosphatase Endocrinology
    PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity [1].
    PTP1B-IN-15
  • HY-R02809
    mmu-miR-1b-5p mimic

    		MicroRNA Cancer
    mmu-miR-1b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-1b-5p mimic
    mmu-miR-1b-5p mimic
  • HY-R02808
    mmu-miR-1b-3p mimic

    		MicroRNA Cancer
    mmu-miR-1b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-1b-3p mimic
    mmu-miR-1b-3p mimic
  • HY-144717
    PTP1B-IN-18

    		Phosphatase Metabolic Disease
    PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research [1].
    PTP1B-IN-18
  • HY-153018
    PTP1B-IN-22

    		Phosphatase Metabolic Disease
    PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes [1].
    PTP1B-IN-22
  • HY-144718
    PTP1B-IN-17

    		Phosphatase Metabolic Disease
    PTP1B-IN-17 (Compound 45), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 30.2 μM. PTP1B-IN-17 can be used for the research of type 2 diabetes.
    PTP1B-IN-17
  • HY-144716
    PTP1B-IN-19

    		Phosphatase Metabolic Disease
    PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.
    PTP1B-IN-19
  • HY-144713
    PTP1B-IN-16

    		Phosphatase Metabolic Disease
    PTP1B-IN-16 (Compound 46), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 12.6 μM. PTP1B-IN-16 can be used for the research of type 2 diabetes.
    PTP1B-IN-16
  • HY-115982
    NS5A-IN-3

    		HCV Protease Infection
    NS5A-IN-3 (Compound 15) is a potent inhibitor of NS5A. NS5A-IN-3 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability. NS5A-IN-3 exhibits a higher resistance barrier than daclatasvir against genotype 1b [1]. NS5A-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NS5A-IN-3
  • HY-118335
    Prazobind

    SZL 49

    		 Adrenergic Receptor Cardiovascular Disease
    Prazobind (SZL 49), a prazosin analog, is a selective α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind can be used for the study of blood pressure [1] .
    Prazobind
  • HY-N10378
    Rubrofusarin 6-O-β-D-glucopyranoside

    		Phosphatase Neurological Disease Metabolic Disease
    Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC50 of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression [1].
    Rubrofusarin 6-O-β-D-glucopyranoside
  • HY-N10064
    Ficusonolide

    		Others Metabolic Disease
    Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
    Ficusonolide
  • HY-N10648
    PTP1B-IN-20

    		Phosphatase Metabolic Disease
    PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition [1].
    PTP1B-IN-20
  • HY-170582
    PTP1B-IN-29

    		Phosphatase Metabolic Disease
    PTP1B-IN-29 (Compound A2B5) is an inhibitor for phosphatase, that inhibits protein tyrosine phosphatase 1B (PTP1B), TCPTP and λPPase with IC50s of 1.27 μM, 4.38 μM and 8.79 μM, respectively. PTP1B-IN-29 can be used in research of diabete and obesity [1].
    PTP1B-IN-29
  • HY-110248
    MI 14

    		PI4K HCV Infection
    MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a [1].
    MI 14
  • HY-12312
    TCS 401
    2 Publications Verification

    		 Phosphatase Metabolic Disease
    TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
    TCS 401
  • HY-RI02808
    mmu-miR-1b-3p inhibitor

    		MicroRNA Cancer
    mmu-miR-1b-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-1b-3p inhibitor
    mmu-miR-1b-3p inhibitor
  • HY-RI02809
    mmu-miR-1b-5p inhibitor

    		MicroRNA Cancer
    mmu-miR-1b-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-1b-5p inhibitor
    mmu-miR-1b-5p inhibitor
  • HY-N2659
    5,7-Diacetoxyflavone

    		Others Others
    5,7-Diacetoxyflavone (compound 1b) is a flavonoid [1].
    5,7-Diacetoxyflavone
  • HY-159694
    IONIS PTP1BRx

    ISIS 404173

    		 Phosphatase Metabolic Disease
    IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity [1].
    IONIS PTP1BRx
  • HY-159694A
    IONIS PTP1BRx sodium

    ISIS 404173 sodium

    		 Phosphatase Metabolic Disease
    IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity [1].
    IONIS PTP1BRx sodium
  • HY-12312A
    TCS 401 free base

    		Phosphatase Metabolic Disease
    TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
    TCS 401 free base
  • HY-N1743
    1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)

    		Phosphatase Metabolic Disease
    1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes [1].
    1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)
  • HY-124896
    Bonannione A

    6-Geranylnaringenin; Mimulone

    		 Phosphatase Apoptosis Autophagy Inflammation/Immunology Cancer
    Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity [1] .
    Bonannione A
  • HY-111087
    AZD-7295

    		HCV Protease Infection Inflammation/Immunology
    AZD-7295 is a HCV NS5A protein inhibitor, with an EC50 of 7 nM for GT-1b replicon [1] .
    AZD-7295
  • HY-101356
    CPCCOEt

    		mGluR Neurological Disease
    CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of metabotropic glutamate receptor 1b (mGluR1b) [1] .
    CPCCOEt
  • HY-N7256
    Dihydrocephalomannine

    		Microtubule/Tubulin Cancer
    Dihydrocephalomannine (compound 1b), an analogue of Paclitaxel, shows reduced cytotoxicity and tubulin binding compared to Paclitaxel [1].
    Dihydrocephalomannine
  • HY-R02809A
    mmu-miR-1b-5p agomir

    		MicroRNA Cancer
    mmu-miR-1b-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-1b-5p agomir
    mmu-miR-1b-5p agomir
  • HY-R02808A
    mmu-miR-1b-3p agomir

    		MicroRNA Cancer
    mmu-miR-1b-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-1b-3p agomir
    mmu-miR-1b-3p agomir
  • HY-145060
    HBV-IN-13

    		HBV Infection
    HBV-IN-12 is a potent hepatitis B surface antigen (HBsAg) inhibitor. From patent WO2021204252A1, compound 1_B [1].
    HBV-IN-13
  • HY-117820
    TASP0390325

    		Vasopressin Receptor Cardiovascular Disease Neurological Disease
    TASP0390325 is a high affinity and orally active arginine vasopressin receptor 1B (V1B receptor) antagonist with antidepressant and anxiolytic activities [1].
    TASP0390325

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