2. Antibodies
  3. Primary Antibodies
  4. Polyclonal Antibodies
  5. IL-8/CXCL8 Antibody

IL-8/CXCL8 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL-8/CXCL8.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

Publications Citing Use of MCE IL-8/CXCL8 Antibody

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

IL-8/CXCL8 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL-8/CXCL8.
Background

IL-8/CXCL8 protein serves as a pivotal chemotactic factor, playing a central role in mediating inflammatory responses by attracting neutrophils, basophils, and T-cells to effectively clear pathogens and protect the host from infections. It also contributes significantly to neutrophil activation. Released in response to inflammatory stimuli, IL-8/CXCL8 exerts its effects by binding to G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes, and endothelial cells. The G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptors, and activation by IL-8 leads to the release of beta and gamma subunits from Galpha (GNAI2 in neutrophils) and subsequent activation of downstream signaling pathways, including PI3K and MAPK pathways. IL-8/CXCL8 forms homodimers, and this dimerization is disrupted by tick evasin-3. Furthermore, IL-8/CXCL8 interacts with TNFAIP6 via its Link domain, and this interaction interferes with chemokine binding to glycosaminoglycans, suggesting a regulatory role in modulating chemokine activity within the inflammatory microenvironment.
Gene ID
SwissProt ID
Synonyms
Interleukin 8; Interleukin8; (Ala-IL-8)77; (Ser-IL-8)72; 3 10C; 310C; AMCF1; b ENAP; CXC chemokine ligand 8; CXCL 8; CXCL8; Emoctakin; GCP-1; GCP1; IL 8; IL-8; IL-8(1-77); IL-8(9-77); IL8; LYNAP; MDNCF; MDNCF-b; MDNCF-c; MONAP; NAF; NAP-1; NAP1; Protein 3 10C; Protein 3-10C; SCYB 8; SCYB8; TSG1.
Molecular Weight

Predicted band size: 8/9 kDa; Observed band size: 10 kDa
Purity

affinity purified
Subcellular Location

Secreted.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Product Categories

Primary Antibody; Rabbit Polyclonal Antibody
Clonality

Polyclonal
Host

Rabbit
Reactivity

Human, Rabbit
Predicted Reactivity

Pig, Cow, Sheep

Note: The predicted reactivity is for reference only, not as a product performance guarantee.
Dilution Ratio

ELISA: 1:5000-10000; IHC-P: 1:100-500; IHC-F: 1:100-500; IF: 1:100-500
Application

ELISA, IHC-P, IHC-F, ICC/IF
Appearance

Liquid
Formulation

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

KLH conjugated synthetic peptide derived from human IL-8: 31-99/99
Database

Entrez Gene: 3576 Human ;

SwissProt: P10145 Human ;

OMIM: 146930 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

IL-8/CXCL8 Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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IL-8/CXCL8 Antibody
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HY-P81106
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