CD80 Antibody (YA3963)

CD80 Antibody (YA3963) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD80. It can be applicated for IHC-P, FC, ELISA assays, in the background of human, mouse, rat, rabbit.

B7-1 is a costimulatory molecule belonging to the immunoglobulin superfamily and plays a crucial role in T-lymphocyte activation. It acts as the primary auxiliary signal, augmenting the MHC/TCR signal in naive T-cells alongside the constitutively expressed CD28 receptor. This interaction activates signaling pathways such as NF-kappa-B and MAPK, leading to cytokine production. Additionally, the CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis in T-cells via the PI3K/Akt pathway. B7-1 also regulates PDL1/PDCD1 interactions to limit excessive PDL1 engagement and its immunosuppressive effects. Expressed on B-cells, it is critical for modulating B-cell and T-cell interactions during germinal center responses, essential for effective humoral immunity (By similarity). Furthermore, B7-1 serves as a receptor for adenovirus subgroup B (Microbial infection).

P33681

Predicted band size: 33 kDa; Observed band size: 50-75 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Rat, Rabbit

IHC: 1/100-1/500; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CD80 (AA: 35-288) expressed in E. Coli.