JNK3 Antibody (YA4929)

JNK3 Antibody (YA4929) is a mouse-derived and non-conjugated monoclonal antibody, targeting to JNK3. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse.

JNK3, a serine/threonine-protein kinase, is a key player in diverse neuronal processes, including proliferation, differentiation, migration, and programmed cell death. Activation of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway by extracellular stimuli, such as pro-inflammatory cytokines or physical stress, involves the phosphorylation and activation of JNK3 by dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7. Within this cascade, JNK3 phosphorylates critical transcription factors, particularly components of AP-1 like JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 plays pivotal roles in neuronal apoptosis by modulating signaling pathways, and it phosphorylates the neuronal microtubule regulator STMN2. Additionally, in the regulation of amyloid-beta precursor protein/APP signaling during neuronal differentiation, JNK3 phosphorylates APP. Furthermore, JNK3 contributes to neurite growth in spiral ganglion neurons and phosphorylates the CLOCK-BMAL1 heterodimer, influencing the photic regulation of the circadian clock. Notably, JNK3 phosphorylates JUND, and this phosphorylation is inhibited in the presence of MEN1.

P53779

Predicted band size: 53 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

WB: 1:500-1:2000; ICC/IF: 1:200-1:1000; ELISA: 1:10000

WB, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human JNK3 (aa28-233) expressed in E. Coli.