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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Metabotropic Glutamate Receptor 2 Antibody (YA3218)

Metabotropic Glutamate Receptor 2 Antibody (YA3218)

Cat. No.: HY-P83473
User Guide for Antibodies Technical Support

Metabotropic Glutamate Receptor 2 Antibody (YA3218) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3218), targeting Metabotropic Glutamate Receptor 2, with a predicted molecular weight of 96 kDa (observed band size: 99 kDa). Metabotropic Glutamate Receptor 2 Antibody (YA3218) can be used for WB, IHC-P experiment in human, mouse background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Metabotropic Glutamate Receptor 2 Antibody (YA3218) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3218), targeting Metabotropic Glutamate Receptor 2, with a predicted molecular weight of 96 kDa (observed band size: 99 kDa). Metabotropic Glutamate Receptor 2 Antibody (YA3218) can be used for WB, IHC-P experiment in human, mouse background.
Background

GRM2 is a dimeric G protein-coupled receptor activated by the excitatory neurotransmitter L-glutamate. It plays critical roles in modulating synaptic transmission and neuronal excitability. Upon glutamate activation, GRM2 inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (by similar). Mechanistically, ligand binding induces a conformational change that triggers G protein-mediated signaling and modulates downstream effectors such as adenylate cyclase. Additionally, GRM2 may mediate neurotransmission suppression or participate in synaptogenesis and synaptic stabilization. In microbial infections, GRM2 facilitates influenza virus internalization and serves as a host entry factor for rabies virus and SARS-CoV-2, which hijack its endocytosis pathway for cellular entry.
Gene ID
SwissProt ID
Synonyms
GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; MGLUR3; Metabotropic glutamate receptor 3; mGluR3
Molecular Weight

Predicted band size: 96 kDa; Observed band size: 99 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human Metabotropic Glutamate Receptor 2
Database

Entrez Gene: 2912 Human ; 108068 Mouse ;

SwissProt: Q14416 Human ; Q14832 Human ; Q14BI2 Mouse ;

OMIM: 604099 Human

Documentation
User Guide for Antibodies (1077 KB)

Metabotropic Glutamate Receptor 2 Antibody (YA3218) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Metabotropic Glutamate Receptor 2 Antibody (YA3218)
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