ULK2 Antibody (YA4362)

ULK2 Antibody (YA4362) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ULK2. It can be applicated for WB, FC, ELISA assays, in the background of human, mouse, rat.

ULK2 is a serine/threonine-protein kinase involved in autophagy induction during starvation. It functions upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate autophagophore formation. As part of autophagy regulatory feedback loops, ULK2 acts both as a downstream effector and negative regulator of mTORC1 through interaction with RPTOR. Activated by AMPK-mediated phosphorylation, it also negatively regulates AMPK by phosphorylating its subunits PRKAA1, PRKAB2, and PRKAG1. Potential phosphorylation targets include ATG13/KIAA0652, FRS2, FRS3, and RPTOR, though these findings require further validation. Not implicated in ammonia-induced autophagy or cerebellar granule neuron (CGN) responses to low potassium. Plays an early role in neuronal differentiation and is essential for granule cell axon formation, potentially via Ras-like GTPase signaling and Rab5-mediated endocytic pathway regulation in developing axons.

Q8IYT8

Predicted band size: 113 kDa; Observed band size: 113 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Rat

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human ULK2 (AA: 1-155) expressed in E. Coli.