CD80 Antibody (YA5496)

CD80 Antibody (YA5496) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD80.

B7-1 is a costimulatory molecule belonging to the immunoglobulin superfamily and plays a crucial role in T-lymphocyte activation. It acts as the primary auxiliary signal, augmenting the MHC/TCR signal in naive T-cells alongside the constitutively expressed CD28 receptor. This interaction activates signaling pathways such as NF-kappa-B and MAPK, leading to cytokine production. Additionally, the CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis in T-cells via the PI3K/Akt pathway. B7-1 also regulates PDL1/PDCD1 interactions to limit excessive PDL1 engagement and its immunosuppressive effects. Expressed on B-cells, it is critical for modulating B-cell and T-cell interactions during germinal center responses, essential for effective humoral immunity (By similarity). Furthermore, B7-1 serves as a receptor for adenovirus subgroup B (Microbial infection).

P33681

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Recombinant Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

ELISA: 1:5000-100000; FC: 1-2μg/Test

FC, ELISA

Liquid

Supplied in Phosphate-buffered solution

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant human CD80