B7-1 Antibody (YA1413)

B7-1 Antibody (YA1413) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1413), targeting B7-1. B7-1 Antibody (YA1413) can be used for FC, ELISA experiment in human background.

B7-1 is a costimulatory molecule belonging to the immunoglobulin superfamily and plays a crucial role in T-lymphocyte activation. It acts as the primary auxiliary signal, augmenting the MHC/TCR signal in naive T-cells alongside the constitutively expressed CD28 receptor. This interaction activates signaling pathways such as NF-kappa-B and MAPK, leading to cytokine production. Additionally, the CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis in T-cells via the PI3K/Akt pathway. B7-1 also regulates PDL1/PDCD1 interactions to limit excessive PDL1 engagement and its immunosuppressive effects. Expressed on B-cells, it is critical for modulating B-cell and T-cell interactions during germinal center responses, essential for effective humoral immunity (By similarity). Furthermore, B7-1 serves as a receptor for adenovirus subgroup B (Microbial infection).

P33681

Predicted band size: 33 kDa; Observed band size: 50-75 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

FC: 1/50-1/100;ELISA: 1/10000

FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant human B7-1 protein