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Results for "

Factor B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adrenergic Receptor (1) Akt (2) AMPK (2) Amyloid-β (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (10) Apoptosis (25) Arp2/3 Complex (1) Autophagy (1) Bacterial (16) Bcl-2 Family (2) Biochemical Assay Reagents (1) BMX Kinase (1) Btk (1) c-Fms (1) c-Met/HGFR (1) Calcineurin (1) Calcium Channel (2) Caspase (5) Cathepsin (1) CCR (1) CD28 (1) CDK (1) Ceramidase (1) CFTR (2) Complement System (16) COX (6) CXCR (1) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Metabolite (2) EGFR (5) Endogenous Metabolite (10) Endothelin Receptor (1) Enterovirus (2) Epigenetic Reader Domain (1) ERK (10) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (2) Factor VIIa (2) Factor Xa (10) Factor XI (1) FAK (2) Fat Mass and Obesity-associated Protein (FTO) (1) Ferroptosis (3) FGFR (6) G Protein-coupled Receptor Kinase (GRK) (1) Glucocorticoid Receptor (2) Glutathione Peroxidase (2) HDAC (1) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (10) Histamine Receptor (2) Histone Demethylase (2) Histone Methyltransferase (1) HSP (1) IFNAR (2) IGF-1R (1) IKK (2) Insecticide (3) Insulin Receptor (4) Interleukin Related (6) Isotope-Labeled Compounds (10) JAK (1) JNK (3) Keap1-Nrf2 (6) Leukotriene Receptor (2) Ligands for E3 Ligase (8) Liposome (1) Lipoxygenase (2) LPL Receptor (1) mAChR (1) MEK (1) MicroRNA (1) Mitophagy (1) MMP (1) Molecular Glues (8) Monoamine Oxidase (1) mRNA (8) mTOR (1) Necroptosis (1) NF-κB (18) NO Synthase (3) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (5) PAI-1 (3) Parasite (1) PD-1/PD-L1 (1) PDGFR (4) PGE synthase (2) Phosphatase (3) Phosphodiesterase (PDE) (1) Phospholipase (1) Platelet-activating Factor Receptor (PAFR) (5) PROTACs (4) Proton Pump (2) Raf (1) RANKL/RANK (3) Ras (1) Reactive Oxygen Species (ROS) (4) Reference Standards (9) Ser/Thr Protease (2) SF3B1 (1) Sirtuin (1) STAT (2) Survivin (1) TGF-β Receptor (2) Thrombin (9) Tissue Factor Pathway Inhibitor (TFPI) (3) TNF Receptor (10) Toll-like Receptor (TLR) (2) Transmembrane Glycoprotein (1) Trk Receptor (2) TRP Channel (2) VEGFR (5)
By Research Areas:	Cancer (83) Cardiovascular Disease (24) Endocrinology (7) Infection (26) Inflammation/Immunology (64) Metabolic Disease (19) Neurological Disease (33)
Oligonucleotides:	Aptamers (5) Nucleotide Analogs (2) mRNA (8) Cationic Lipids (1) Antisense Oligonucleotides (2)

192

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

186

Recombinant Proteins

Isotope-Labeled Compounds

122

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136556

Factor B-IN-1	Complement System	Inflammation/Immunology
Factor B-IN-1 is a Factor B inhibitor extracted from patent WO2013164802A1, Example 24 .

HY-N8118

*Euphorbia factor* L7b**	Others	Others
Euphorbia factor L7b is an isolathyrolditerpene compound .

HY-127105A

Iptacopan hydrochloride 5+ Cited Publications LNP023 hydrochloride	Complement System	Metabolic Disease Inflammation/Immunology
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. LNP023 inhibits factor B with an IC₅₀ value of 10 nM .

HY-178284

Factor B-IN-7	Complement System	Inflammation/Immunology
Factor B-IN-7 (Compound (I)) is a selective Factor B inhibitor. Factor B-IN-7 inhibits Factor B-C3b interaction to suppress complement hyperactivation. Factor B-IN-7 is promising for research of paroxysmal nocturnal hemoglobinuria (PNH), C3 glomerulopathy, and age-related macular degeneration (AMD) associated with complement-mediated diseases .

HY-177388

Factor B-IN-6	Complement System	Inflammation/Immunology
Factor B-IN-6 is an orally active Factor B inhibitor. Factor B-IN-6 exhibits significant inhibitory activity against activation of the human serum serotonin pathway. Factor B-IN-6 can improve the severity of renal lesions and renal function, and reduce urinary protein in animal models. Factor B-IN-6 is useful for kidney disease research .

HY-174913

Factor B-IN-5	Complement System	Metabolic Disease Inflammation/Immunology
Factor B-IN-5 is an orally active *complement factor* B (CFB)** inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy .

HY-147605

Factor B-IN-3	Complement System	Inflammation/Immunology
Factor B-IN-3 (Example 3 target compound) is a potent *complement factor* B** inhibitor. Factor B-IN-3 can be used for the research of diseases related to inflammation and immunity .

HY-147606

Factor B-IN-4	Complement System	Inflammation/Immunology
Factor B-IN-4 (Example 13 target compound) is a potent *complement factor* B inhibitor, with an IC₅₀** of 1 μM. Factor B-IN-4 can be used for the research of diseases related to inflammation and immunity .

HY-147604

Factor B-IN-2	Complement System	Inflammation/Immunology
Factor B-IN-2 (Example 1 target compound) is a potent *complement factor* B inhibitor, with an IC₅₀** of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity .

HY-112935

Nonacog alfa BAX326; Coagulation Factor IX [Recombinant]; BeneFIX	Ser/Thr Protease	Others
Nonacog alfa (BAX326) is a recombinant human factor IX that can be used for the research of haemophilia B .

HY-148370A

IONIS-FB-LRx sodium Sefaxersen sodium; RG6299 sodium	Complement System	Others
IONIS-FB-LRx sodium is a specific antisense oligonucleotide (ASO) targeting *complement factor* B (CFB)**. IONIS-FB-LRx sodium effectively reduces circulating levels of CFB, and can be used for geographic atrophy (GA) research .

HY-148370

IONIS-FB-LRx Sefaxersen; RG6299	Complement System	Others
IONIS-FB-LRx is a specific antisense oligonucleotide (ASO) targeting *complement factor* B (CFB)**. IONIS-FB-LRx effectively reduces circulating levels of CFB. IONIS-FB-LRx can be used for geographic atrophy (GA) research .

HY-127105

Iptacopan 5+ Cited Publications LNP023	Complement System	Metabolic Disease Inflammation/Immunology
Iptacopan (LNP023) is a first-in-class, orally bioavailable, highly potent and highly selective factor B inhibitor with an IC₅₀ value of 10 nM. Iptacopan shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. Iptacopan targets the underlying cause of complement 3 glomerulopathy (C3G) .

HY-147607

Lanoracopan	Complement System	Inflammation/Immunology
Factor B-IN-5 (Example 5 target compound) is a potent *complement factor* B inhibitor, with an IC₅₀** of 1.2 μM. Factor B-IN-5 can be used for the research of diseases related to inflammation and immunity .

HY-174509

Human VEGFB mRNA	mRNA	Cancer
Human VEGFB mRNA encodes the human vascular endothelial growth factor B (VEGFB) protein, a member of the platelet-derived growth factor (PDGF)/ vascular endothelial growth factor (VEGF) family. VEGFB is a growth factor for endothelial cells.

HY-N10431

Stigmane B	Keap1-Nrf2	Neurological Disease
Stigmane B (Compound 2) is a *nuclear factor* E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS)** generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-B0441

Tobramycin 10+ Cited Publications Nebramycin Factor 6; Deoxykanamycin B	Bacterial Antibiotic	Infection Cancer
Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .

HY-P990378

*Anti-Complement Factor* P/Properdin Antibody**	Complement System	Inflammation/Immunology
Anti-Complement Factor P/Properdin Antibody is a humanized antibody expressed in CHO, targeting *Complement Factor* P/Properdin*. Anti-Complement Factor* P/Properdin Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Complement Factor P/Properdin Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-122700

Factor D inhibitor 6	Complement System	Inflammation/Immunology
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC₅₀ of 30 nM and a K_d of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .

HY-125086

Leustroducsin B LSN-B	c-Fms	Cardiovascular Disease
Leustroducsin B is a *colony-stimulating factor* (CSF)** inducer. Leustroducsin B induces CSF production in bone marrow stromal cells .

HY-160048

PEG40K unconjugated/naked AX102 sodium	PDGFR	Cancer
PEG40K unconjugated/naked AX102 sodium is AX102 without PEG40K conjugation. AX102 is a DNA oligonucleotide aptamer for platelet-derived growth factor PDGF-B. AX102 is 34 bases in length, selectively binds platelet-derived growth factor B (PDGF-B), and causes tumor vessel regression .

HY-174568

Human NFKB2 mRNA	mRNA	Inflammation/Immunology
Human NFKB2 mRNA encodes the human nuclear factor kappa B subunit 2 (NFKB2) protein, a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. NFKB2 can function as either a transcriptional activator or repressor depending on its dimerization partner.

HY-111492

DIM-C-pPhOCH3 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A	Cancer
DIM-C-pPhOCH₃ is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

HY-N12566

Erinacin B	Others	Neurological Disease
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-N11640

Methyl Ganoderic acid B	Others	Neurological Disease
Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects .

HY-B0441A

Tobramycin sulfate 10+ Cited Publications Nebramycin Factor 6 sulfate; Deoxykanamycin B sulfate	Bacterial Antibiotic	Infection Cancer
Tobramycin sulfate (Nebramycin Factor 6 sulfate) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .

HY-B0441R

Tobramycin (Standard) Nebramycin Factor 6 (Standard); Deoxykanamycin B (Standard)	Reference Standards Bacterial Antibiotic	Infection Cancer
Tobramycin (Standard) is the analytical standard of Tobramycin. This product is intended for research and analytical applications. Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .

HY-174552

Human PDGFB mRNA	mRNA	Cancer
Human PDGFB mRNA encodes the human platelet derived growth factor B (PDGFB) protein, a member of the platelet-derived growth factor family. PDGFB plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.

HY-174668

Human HNF1B mRNA	mRNA	Metabolic Disease
Human HNF1B mRNA encodes the human HNF1 homeobox B (HNF1B) protein, a member of the homeodomain-containing superfamily of transcription factors. HNF1B has been shown to function in nephron development, and regulates development of the embryonic pancreas.

HY-111053

P11	Phospholipase	Cancer
P11 is a selective inhibitor of platelet-activating factor acetylhydrolases (PAFAHs) 1b2 and 1b3 that impairs cancer cell survival. P11 exhibits IC₅₀ values of ~40 and 900 nM for PAFAH1b2 and 1b3, respectively .

HY-P3206A

*Serum thymic factor* acetate** Thymulin acetate; Thymic Factor acetate	ERK	Neurological Disease Inflammation/Immunology Endocrinology
Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .

HY-N10009

Cudraflavone B	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin	Inflammation/Immunology
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of *nuclear factor* κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1**. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

HY-100540

Golgicide A 5+ Cited Publications GCA	Enterovirus	Infection Cancer
Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 . Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .

HY-P3206

Serum thymic factor Thymulin; Thymic Factor	ERK	Neurological Disease Inflammation/Immunology Endocrinology
Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .

HY-N14982

Ferrimycin A1	Antibiotic	Infection Inflammation/Immunology
Ferrimycin A1 is an iron-containing peptide antibiotic and an acyl derivative of ferrimycin B, a competitive antagonist and microbial growth factor .

HY-153480A

ARC19499 sodium BAX499 sodium	Factor Xa Factor VIIa Tissue Factor Pathway Inhibitor (TFPI)	Others
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-Y1322

Triphenyl phosphate	Monoamine Oxidase Reactive Oxygen Species (ROS) NF-κB Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology
Triphenyl phosphate is an organic phosphate flame retardant. Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, leading to abnormal neurological behavior. Triphenyl phosphate promotes oxidative stress by inducing inflammatory factors like nuclear factor kappa B (NFκB), interleukin-6, and *tumor necrosis factor* α**. Triphenyl phosphate can also cause allergic contact dermatitis .

HY-153480

ARC19499 BAX499	Factor Xa Factor VIIa Tissue Factor Pathway Inhibitor (TFPI)	Others
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

HY-P991213

Nonacog gamma	Factor XI	Cardiovascular Disease
Nonacog gamma is a coagulation factor IX (FIX) supplement. Nonacog gamma activates coagulation factor X (FX), promotes the generation of thrombin, and then converts fibrinogen into fibrin, forming a stable blood clot to exert hemostatic activity. Nonacog gamma is promising for research of hemophilia B .

HY-124875

Arylsulfonamide 64B HIF inhibitor 64B	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Arylsulfonamide 64B (HIF inhibitor 64B) is an inhibitor of the hypoxia-induced factor (HIF). Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma mouse model .

HY-129973

4-Chlorophenylurea NSC-12971; 4-Chlorophenylurea	Factor Xa	Others
4-Chlorophenylurea is metabolite of diflubenzuron (HY-B1973). 4-Chlorophenylurea can be used to form factor Xa inhibitors .

HY-110154

NSC636819	Histone Demethylase	Cancer
NSC636819 is a competitive and selective inhibitor of *KDM4A/KDM4B. KDM4A/KDM4B are potential progression factors* for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer .

HY-N0366

Sennoside B 3 Publications Verification	PDGFR	Inflammation/Immunology
Sennoside B is a potent and orally active *platelet-derived growth factor* (PDGF)** inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis .

HY-162599

Spirohypertone B	TNF Receptor	Infection Cancer
Spirohypertone B is a potent *Tumor necrosis factor-α (TNF-α)* inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559) .

HY-N11920

Kadsurenin B	Platelet-activating Factor Receptor (PAFR)	Infection Neurological Disease Inflammation/Immunology
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-174684

Human FLT1 mRNA	mRNA	Cancer
Human FLT1 mRNA encodes the human fms related receptor tyrosine kinase 1 (FLT1) protein, a member of the vascular endothelial growth factor receptor (VEGFR) family. FLT1 binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis.

HY-N12173

Isonanangenine B SF002-96-1	Survivin	Cancer
Isonanangenine B (SF002-96-1) is a selective survivin inhibitor (IC₅₀=1.6 µM). Isonanangenine B blocks the binding of key transcription factors, such as Stat3 and NF-κB, to the survivin promoter. Isonanangenine B is promising for research of cancers .

HY-112648

Stafib-2	STAT	Others
Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC₅₀ of 82 nM and 1.7 μM for *STAT5b* and STAT5a, respectively. Stafib-2 exhibits poor cell permeability .

HY-111547

M1001	HIF/HIF Prolyl-Hydroxylase	Cancer
M1001 is a weak hypoxia-inducible factor-2α (HIF-2α) agonist. M1001 can bind to the HIF-2α PAS-B domain, with a K_d of 667 nM. M1001 can be used in chronic kidney disease research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8118

*Euphorbia factor* L7b**	other families Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Plants Disease Research Fields	Others
Euphorbia factor L7b is an isolathyrolditerpene compound .

HY-B0441

Tobramycin Maximum Cited Publications 12 Publications Verification Nebramycin Factor 6; Deoxykanamycin B	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .

HY-B0441A

Tobramycin sulfate Maximum Cited Publications 12 Publications Verification Nebramycin Factor 6 sulfate; Deoxykanamycin B sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Tobramycin sulfate (Nebramycin Factor 6 sulfate) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .

HY-N10431

Stigmane B	Zea mays L. Terpenoids Gramineae Source classification Diterpenoids Plants	Keap1-Nrf2
Stigmane B (Compound 2) is a *nuclear factor* E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS)** generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-125086

Leustroducsin B LSN-B	Structural Classification Natural Products Microorganisms Source classification	c-Fms
Leustroducsin B is a *colony-stimulating factor* (CSF)** inducer. Leustroducsin B induces CSF production in bone marrow stromal cells .

HY-N12566

Erinacin B	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-N11640

Methyl Ganoderic acid B	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects .

HY-B0441R

Tobramycin (Standard) Nebramycin Factor 6 (Standard); Deoxykanamycin B (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Reference Standards Bacterial Antibiotic
Tobramycin (Standard) is the analytical standard of Tobramycin. This product is intended for research and analytical applications. Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .

HY-N10009

Cudraflavone B	Structural Classification Brosimopsis oblongifolia Source classification Phenols Polyphenols Plants Moraceae	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of *nuclear factor* κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1**. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-N14982

Ferrimycin A1	Structural Classification Natural Products Microorganisms Source classification	Antibiotic
Ferrimycin A1 is an iron-containing peptide antibiotic and an acyl derivative of ferrimycin B, a competitive antagonist and microbial growth factor .

HY-N0366

Sennoside B 3 Publications Verification	Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Cassia angustifolia Plants Disease Research Fields Cancer	PDGFR
Sennoside B is a potent and orally active *platelet-derived growth factor* (PDGF)** inhibitor. Sennoside B inhibits cell proliferation and the expression of phosphorylation of PDGFR-β, STAT-5, AKT and ERK induced by PDGF-BB. Sennoside B shows gastroprotective activities. Sennoside B has the potential for the research of gastritis .

HY-162599

Spirohypertone B	Source classification Hypericaceae Hypericum patulum Thunb. Plants	TNF Receptor
Spirohypertone B is a potent *Tumor necrosis factor-α (TNF-α)* inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559) .

HY-N11920

Kadsurenin B	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi	Platelet-activating Factor Receptor (PAFR)
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-N12173

Isonanangenine B SF002-96-1	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Survivin
Isonanangenine B (SF002-96-1) is a selective survivin inhibitor (IC₅₀=1.6 µM). Isonanangenine B blocks the binding of key transcription factors, such as Stat3 and NF-κB, to the survivin promoter. Isonanangenine B is promising for research of cancers .

HY-126307

Urolithin B 5 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB JNK ERK Akt AMPK Endogenous Metabolite
Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality .

HY-B0441AR

Tobramycin sulfate (Standard) Nebramycin Factor 6 sulfate (Standard); Deoxykanamycin B sulfate (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Reference Standards Bacterial Antibiotic
Tobramycin (sulfate) (Standard) is the analytical standard of Tobramycin (sulfate). This product is intended for research and analytical applications. Tobramycin sulfate (Nebramycin Factor 6 sulfate) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms[1].

HY-N10313

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases *apoptosis-inducing factor* (AIF) and Bax expression and suppresses Keap1-Nrf2** .

HY-129209

Myrotoxin B	Structural Classification Natural Products Source classification Morus alba L. Plants Moraceae	Others
Myrotoxin B is a toxin produced by the fungus Myrothecium roridum that can induce necrotic lesions in mulberry leaves. Myrotoxin B can also promote the infection rate of Myrothecium roridum, acting as an infection factor, increasing the ability of the fungus to infect host plants. Myrotoxin B can be used in plant pathology and mycotoxin research .

HY-126307R

Urolithin B (Standard)	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	NF-κB JNK ERK Akt AMPK Endogenous Metabolite
Urolithin B (Standard) is the analytical standard of Urolithin B. This product is intended for research and analytical applications. Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality .

HY-N3938

Gelsemiol	Structural Classification Iridoids Terpenoids Source classification Populus tomentosa Plants Salicaceae	Others
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-N13955

Bacithrocin B	Structural Classification Natural Products Microorganisms Source classification	Thrombin Factor Xa Ser/Thr Protease
Bacithrocin B is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 84 μM, 17 μM, 1.7 μM, and 0.02 μM, respectively .

HY-N14933

Aggreceride B	Structural Classification Natural Products Microorganisms Source classification	Platelet-activating Factor Receptor (PAFR)
Aggreceride B is a platelet aggregation inhibitor. Aggreceride B shows an inhibitory activity against aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590) and PAF (platelet activating factor), but was less active against aggregation induced by collagen .

HY-N0784

Ginkgolide B 5+ Cited Publications BN-52021	Structural Classification Ginkgoaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Ginkgo biloba Disease Research Fields Cancer	Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N4171

Dihydrocucurbitacin B	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

HY-N0784R

Ginkgolide B (Standard) BN-52021 (Standard)	Structural Classification Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Ginkgo biloba	Reference Standards Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (Standard) is the analytical standard of Ginkgolide B. This product is intended for research and analytical applications. Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N3643

Cryptomeridiol	Phaulopsis dorsiflora (Retzius) Santapau Acanthaceae Source classification Plants	Platelet-activating Factor Receptor (PAFR)
Cryptomeridiol is a *platelet-activating factor* (PAF) receptor** binding inhibitor. Cryptomeridiol has melanogenesis inhibitory activity in the α-MSH (HY-P0252)-stimulated B16 melanoma cells .

HY-N8936

Narchinol B	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

HY-B1746

Pyridoxamine 5′-phosphate	Structural Classification Alkaloids Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of Pyridoxal 5'-?phosphate monohydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase Leukotriene Receptor NF-κB
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and *nuclear factor-kappa B (NF-κB)* activation and tumor necrosis factor alpha generation production .

HY-N15720

HN-saponin F Pulsatilla saponin B	Triterpenes Structural Classification Polysaccharides Caprifoliaceae Terpenoids Source classification Plants Lonicera macrantha (D. Don) Spreng. Saccharides	Others
HN-saponin F (Pulsatilla saponin B) is an orally active triterpenoid saponin found in Lonicera macranthoides. HN-saponin F exerts anti-inflammatory activity by regulating inflammation-related pathways (e.g., inhibiting pro-inflammatory factor release). HN-saponin F is promising for research of inflammatory diseases .

HY-N2106R

Dehydroevodiamine (Standard)	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Indole Alkaloids	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N2106

Dehydroevodiamine 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N2056R

11-Keto-beta-boswellic acid (Standard) 11-Keto-β-boswellic acid (Standard)	Triterpenes Structural Classification Terpenoids Source classification Boswellia serrata Plants Burseraceae	Reference Standards Lipoxygenase Leukotriene Receptor NF-κB
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-N6769

Radicicol 3 Publications Verification Monorden	Structural Classification Antifungal Classification of Application Fields Marine natural products Source classification Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Marine microorganism Disease Research Fields	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-N2424

Flavone 2-Phenyl-4-chromone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	CDK Apoptosis Caspase
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21_waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21_waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .

HY-N0632

Esculentoside A 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Phytolacca acinosa Roxb. Plants Inflammation/Immunology Disease Research Fields Phytolaccaceae	COX NF-κB
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-N9736

6,4'-Dihydroxy-7-methoxyflavanone	Structural Classification Flavonoids Dalbergia odorifera T. Chen Flavones Leguminosae Source classification Plants	Calcineurin
6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis .

HY-N0787

Cryptochlorogenic acid 1 Publications Verification 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid	Structural Classification Classification of Application Fields Source classification Plants Moraceae Endogenous metabolite Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Disease Research Fields Morus alba Linn.	Endogenous Metabolite NF-κB Keap1-Nrf2 mTOR HIF/HIF Prolyl-Hydroxylase
Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-κB activity, promoting Nrf2 nuclear transfer, and regulating PI3Kα/Akt/ mTOR / HIF-1α signaling pathway Induced physiological stress response .

HY-W010737

Guanosine-5'-triphosphate disodium salt 5+ Cited Publications 5'-GTP disodium salt	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite MicroRNA
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-12695

Guanosine 5'-triphosphate trisodium salt 4 Publications Verification 5'-GTP trisodium salt	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

HY-N0632R

Esculentoside A (Standard)	Triterpenes Structural Classification Terpenoids Source classification Phytolacca acinosa Roxb. Plants Phytolaccaceae	Reference Standards COX NF-κB
Esculentoside A (Standard) is the analytical standard of Esculentoside A. This product is intended for research and analytical applications. Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .

HY-N13009

MO-2097	Structural Classification Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Raf HIF/HIF Prolyl-Hydroxylase ERK MEK Reactive Oxygen Species (ROS) Apoptosis Caspase
MO-2097 is a RAF-1/HIF-1α inhibitor. MO-2097 induces RAF-1 destabilization, leading to a reduction in EMT-associated transcription factors and mesenchymal markers. MO-2097 inhibits HIF-1a protein expression mediated by hnRNPA2B1 under hypoxic and mimetic hypoxia. MO-2097 induces mitochondrial ROS, which leads to apoptosis in cells. MO-2097 effectively suppresses colorectal cancer metastasis by inhibiting the RAF/MEK/ERK signaling pathway. MO-2097 attenuates tumor growth in a xenograft HCT116 cell mouse model. MO-2097 can be used for the study of colorectal cancer .

HY-N3097R

Pellitorine (Standard)	Alkaloids Other Alkaloids Source classification Piperaceae Plants Piper nigrum Linn.	Reference Standards TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.

HY-N3097

Pellitorine	Alkaloids Classification of Application Fields Other Alkaloids Source classification Piperaceae Plants Disease Research Fields Piper nigrum Linn. Biological Pesticide Research Cancer Agricultural Research	TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .

HY-N6871

Abietic acid 2 Publications Verification	Infection Structural Classification Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial IKK Ferroptosis
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

Cat. No.	Product Name	Chemical Structure

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid (HY-B0167). Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-B1811AS1

Vasopressin-d5 TFA

Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5 (HY-B1811S1). Vasopressin-d5 TFA is an isotope-labeled compound of Vasopressin (HY-B1811). Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-175483S

TrkB activator-1

TrkB activator-1 is a specific, orally active and brain-penetrant tropomyosin receptor kinase B (TrkB) activator. TrkB activator-1 shows potent antidepressant effects through activation of the activates the BDNF (brainderived neurotrophic factor)-Tropomyosin-related kinase B (TrkB)-CREB (cAMP response element binding protein) signaling aixs. TrkB activator-1 increaes neuroplasticity. TrkB activator-1 can be used for the research of neurological disease, such as depression .

HY-114456S

Ganglioside GM3-d7

Ganglioside GM3-d₇ is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-B0636S1

Triamcinolone acetonide-13C3

Triamcinolone acetonide- ¹³C₃ is the ¹³C-labeled Triamcinolone acetonide (HY-B0636). Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .

HY-W754236

(R)-Carnitine Hydrochloride-13C3

(R)-Carnitine Hydrochloride- ¹³C₃ is the ¹³C-labeled L-Carnitine hydrochloride (HY-B2246). L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .

HY-B0399S2

L-Carnitine-13C3

L-Carnitine- ¹³C₃ ((R)-Carnitine- ¹³C₃) is the ¹³C--labeled L-Carnitine (HY-B0399). L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .

HY-A0003S2

Lenalidomide-13C5,15N

Lenalidomide- ¹³C₅, ¹⁵N is ¹⁵N and ¹³C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-A0003S3

Lenalidomide-d4

Lenalidomide-d₄ (CC-5013-d₄) is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

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