Visfatin Antibody (YA5011)

Visfatin Antibody (YA5011) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PBEF. It can be applicated for WB, ELISA assays, in the background of human.

PBEF catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce nicotinamide mononucleotide, an intermediate in NAD biosynthesis. As the rate-limiting component in mammalian NAD biosynthesis, its secreted form acts both as an immunomodulatory cytokine and an anti-diabetic adipokine, though it lacks enzymatic activity (partly due to insufficient ATP activation in extracellular spaces and plasma). The protein modulates circadian clock function via NAMPT-dependent oscillatory NAD production, which regulates the oscillation of clock target gene expression by releasing the core clock component CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

P43490

Predicted band size: 56 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of PBEF expressed in E. Coli.