TCEB3 Protein, Human (Sf9, His, StrepⅡ)

TCEB3, also known as SIII, acts as a key transcription elongation factor that promotes RNA polymerase II progression beyond the blocking site. It interacts with SIII regulatory subunits B and C to form the elongin BC complex, which significantly enhances the transcriptional activity of subunit A. TCEB3 Protein, Human (Sf9, His, Strep) is the recombinant human-derived TCEB3 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag.

TCEB3, also referred to as SIII, functions as a general transcription elongation factor, facilitating RNA polymerase II transcription elongation beyond template-encoded arresting sites. The transcriptional activity of subunit A is significantly boosted by its interaction with the dimeric complex formed by the SIII regulatory subunits B and C, collectively known as the elongin BC complex. TCEB3 operates within a multisubunit assembly, including elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1, and CUL5. In this context, it polyubiquitinates monoubiquitinated POLR2A, contributing to the regulation of transcriptional processes.

Human

Sf9 insect cells

N-StrepⅡ;N-8*His

Q14241 (H2-R798)

6924

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.