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Glycine-<sup>15</sup>N,d<sub>2</sub>

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-A0042S1
    Rufinamide-15N,d2

    CGP 33101-<sup>15sup>N,d<sub>2sub>; E 2080-<sup>15sup>N,d<sub>2sub>; RUF 331-<sup>15sup>N,d<sub>2sub>

    		 Isotope-Labeled Compounds Sodium Channel Neurological Disease
    Rufinamide- 15N,d2 (CGP 33101- 15N,d2) is the deuterium and 15N labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na + current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome [2] .
    Rufinamide-15N,d2
  • HY-W727879
    Upadacitinib-15N,d2
    1 Publications Verification

    ABT-494-<sup>15sup>N,d<sub>2sub>

    		 Isotope-Labeled Compounds Others
    Upadacitinib- 15N,d2 (ABT-494- 15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib- 15N,d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib- 15N,d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib- 15N,d2 (ABT-494) can be used for several autoimmune disorders research [2].
    Upadacitinib-15N,d2
  • HY-16973S
    Fluralaner-13C2,15N,d3

    A1443-<sup>13sup>C<sub>2sub>,<sup>15sup>N,d<sub>3sub>; AH252723-<sup>13sup>C<sub>2sub>,<sup>15sup>N,d<sub>3sub>

    		 Isotope-Labeled Compounds Parasite Infection
    Fluralaner- 13C2, 15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
    Fluralaner-13C2,15N,d3
  • HY-17427S
    Emtricitabine-15N,d2

    BW1592-<sup>15sup>N,d<sub>2sub>

    		 HIV Reverse Transcriptase Endogenous Metabolite Infection
    Emtricitabine- 15N,d2 is a 15N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
    Emtricitabine-15N,d2
  • HY-129242S
    Tempone-15N,d16

    4-Oxo-Tempo-<sup>15sup>N,d<sub>16sub>

    		 Isotope-Labeled Compounds Others
    Tempone- 15N,d16 is the deuterium and 15N labeled Tempone .
    Tempone-15N,d16
  • HY-A0042S2
    Rufinamide-15N,d2-1

    CGP 33101-<sup>15sup>N,d<sub>2sub>-1; E 2080-<sup>15sup>N,d<sub>2sub>-1; RUF 331-<sup>15sup>N,d<sub>2sub>-1

    		 Isotope-Labeled Compounds Sodium Channel Neurological Disease
    Rufinamide- 15N,d2-1 (CGP 33101- 15N,d2-1) is 15N- and deuterium-labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na + current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome [2] .
    Rufinamide-15N,d2-1
  • HY-B1418S2
    Tazobactam-15N,d2

    CL-298741-<sup>15sup>N<sub>,d<sub>2sub>; YTR-830H-<sup>15sup>N<sub>,d<sub>2sub>

    		 Isotope-Labeled Compounds Bacterial Antibiotic Beta-lactamase Infection Cancer
    Tazobactam- 15N,d2 (CL-298741- 15N,d2) is 15N and deuterium labeled Tazobactam. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research [2].
    Tazobactam-15N,d2
  • HY-10285S
    Saxagliptin-15N,d2 hydrochloride

    BMS-477118-<sup>15sup>N,d<sub>2sub> Hydrochloride

    		 Isotope-Labeled Compounds Dipeptidyl Peptidase Metabolic Disease
    Saxagliptin-15N,d2 Hydrochloride (BMS-477118-15N,d2 Hydrochloride) is the 15N and deuterium labeled isotope of Saxagliptin (HY-10285). Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research [2] .
    Saxagliptin-15N,d2 hydrochloride
  • HY-N0650S9
    L-Serine-15N,d3

    (-)-Serine-<sup>15sup>N,d<sub>3sub>; (S)-Serine-<sup>15sup>N,d<sub>3sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Cancer
    L-Serine- 15N,d3 is the deuterium and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
    L-Serine-15N,d3
  • HY-B0250S
    Lamivudine-15N,d2

    BCH-189-<sup>15sup>N,d<sub>2sub>

    		 HBV HIV Reverse Transcriptase Isotope-Labeled Compounds Infection Cancer
    Lamivudine- 15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS [2].
    Lamivudine-15N,d2
  • HY-W776833
    MTSSL-15N,d15-1

    Otmpmms-<sup>15sup>N,d<sub>15sub>

    		 Isotope-Labeled Compounds Biochemical Assay Reagents Others
    MTSSL- 15N,d15-1 (Otmpmms- 15N,d15) is the deuterium and 15N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .
    MTSSL-15N,d15-1
  • HY-N0717S3
    L-Valine-13C5,15N,d2

    (S)-Valine-<sup>13sup>C<sub>5sub>,<sup>15sup>N,d<sub>2sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    L-Valine- 13C5, 15N,d2 is the deuterium, 13C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
    L-Valine-13C5,15N,d2
  • HY-N0717S9
    L-Valine-15N,d8

    (S)-Valine-<sup>15sup>N,d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    L-Valine- 15N,d8 is the deuterium and 15 N labeled L-Valine . L-Valine (Valine) is a new nonlinear semiorganic material [2].
    L-Valine-15N,d8
  • HY-N0650S3
    L-Serine-13C3,15N,d3

    (-)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>3sub>; (S)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>3sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Cancer
    L-Serine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
    L-Serine-13C3,15N,d3
  • HY-10981S2
    Lenvatinib-15N,d4

    E7080-<sup>15sup>N,d<sub>4sub>

    		 VEGFR c-Kit FGFR RET PDGFR Isotope-Labeled Compounds Cancer
    Lenvatinib- 15N,d4 is 15N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities [2].
    Lenvatinib-15N,d4
  • HY-A0166S
    Cilastatin-15N,d3

    MK0791-<sup>15sup>N,d<sub>3sub>

    		 Bacterial Antibiotic Infection
    Cilastatin- 15N,d3 is a 15N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct [2] .
    Cilastatin-15N,d3
  • HY-N0771S6
    L-Cysteine-13C3,15N,d3

    Cysteine-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>3sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    L-Cysteine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Isoleucine (HY-Y0337). L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
    L-Cysteine-13C3,15N,d3
  • HY-N0717S2
    L-Valine-13C5,15N,d8

    (S)-Valine-<sup>13sup>C<sub>5sub>,<sup>15sup>N,d<sub>8sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    L-Valine- 13C5, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
    L-Valine-13C5,15N,d8
  • HY-B0084S4
    Dienogest-13C,15N,d4

    STS 557-<sup>13sup>C,<sup>15sup>N,d<sub>4sub>

    		 Isotope-Labeled Compounds Progesterone Receptor Endocrinology
    Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the 13C, 15N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia [2].
    Dienogest-13C,15N,d4
  • HY-N0229S14
    L-Alanine-15N,d4

    L-2-Aminopropionic acid-<sup>15sup>N,d<sub>4sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease Metabolic Disease
    L-Alanine- 15N,d4 is the deuterium and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-15N,d4
  • HY-W653882
    Carbamazepine-d2,15N

    CBZ-d<sub>2sub>,<sup>15sup>N; NSC 169864-d<sub>2sub>,<sup>15sup>N

    		 Isotope-Labeled Compounds Others
    Carbamazepine-d2,15N is a deuterated labeled Carbamazepine-d2,15N .
    Carbamazepine-d2,15N
  • HY-176305S
    Neurofilament, U-15N

    		Isotope-Labeled Compounds Neurological Disease
    Neurofilament, U- 15N is the 15N-labeled Neurofilament.
    Neurofilament, U-15N
  • HY-N0229S5
    L-Alanine-13C3,15N,d4

    L-2-Aminopropionic acid-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>4sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease Metabolic Disease
    L-Alanine- 13C3, 15N,d4 is the deuterium, 13C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-13C3,15N,d4
  • HY-N0215S14
    L-Phenylalanine-15N,d8

    (S)-2-Amino-3-phenylpropionic acid-<sup>15sup>N,d<sub>8sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals [2] .
    L-Phenylalanine-15N,d8
  • HY-N0215S9
    L-Phenylalanine-13C9,15N,d8

    (S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C<sub>9sub>,<sup>15sup>N,d<sub>8sub>

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 13C9, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals [2] .
    L-Phenylalanine-13C9,15N,d8
  • HY-W759458
    N-Phthaloylglycine-13C2,15N

    Phthaloyl Glycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N

    		 Isotope-Labeled Compounds Cancer
    N-Phthaloylglycine- 13C2, 15N (Phthaloyl glycine- 13C2, 15N) is the 13C- and 15N-labeled N-Phthaloylglycine (HY-W014665). N-Phthaloylglycine (Phthaloyl glycine) is an FX-type hapten that attaches to free amine groups of proteins .
    N-Phthaloylglycine-13C2,15N
  • HY-Y1250S6
    Fmoc-Gly-OH-13C2,15N

    Fmoc Glycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N

    		 Isotope-Labeled Compounds Influenza Virus Bacterial Infection
    Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
    Fmoc-Gly-OH-13C2,15N
  • HY-Y0966S9
    Glycine-15N,d2

    		Isotope-Labeled Compounds Endogenous Metabolite iGluR Neurological Disease
    Glycine- 15N,d2 is the deuterium and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-15N,d2
  • HY-13613S2
    Dutasteride-13C,15N,d

    GG 745-<sup>13sup>C,<sup>15sup>N,d; GI 198745-<sup>13sup>C,<sup>15sup>N,d

    		 5 alpha Reductase Apoptosis Isotope-Labeled Compounds Cancer
    Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
    Dutasteride-13C,15N,d
  • HY-N0667S2
    L-Asparagine-15N2 monohydrate

    (-)-Asparagine-<sup>15sup>N<sub>2sub> monohydrate; Asn-<sup>15sup>N<sub>2sub> monohydrate; Asparamide-<sup>15sup>N<sub>2sub> monohydrate

    		 Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis Inflammation/Immunology
    L-Asparagine- 15N2 monohydrate is the 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia [2] .
    L-Asparagine-15N2 monohydrate
  • HY-Y0966S11
    Glycine-13C2,15N,d2

    		iGluR Endogenous Metabolite Neurological Disease
    Glycine- 13C2, 15N,d2 is the deuterium, 13C and 15N labeled Glycine . Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors [2].
    Glycine-13C2,15N,d2
  • HY-Y0271S
    Urea-15N2

    Carbamide-<sup>15sup>N<sub>2sub>; Carbonyldiamide-<sup>15sup>N<sub>2sub>

    		 Endogenous Metabolite Cardiovascular Disease Cancer
    Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms . A potent emollient and keratolytic agent [2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function . Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
    Urea-15N2
  • HY-N1150S9
    Thymidine-15N2

    DThyd-<sup>15sup>N<sub>2sub>; NSC-<sup>15sup>N<sub>2sub>

    		 DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus Cancer
    Thymidine- 15N2 is the 15N labeled Thymidine . Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication [2] .
    Thymidine-15N2
  • HY-Y1250S5
    Fmoc-Gly-OH-13C2

    Fmoc-Glycine-<sup>13sup>C<sub>2sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Inflammation/Immunology
    Fmoc-Gly-OH- 13C2 is a 13C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds [2].
    Fmoc-Gly-OH-13C2
  • HY-N0623S8
    L-Tryptophan-15N2

    Tryptophan-<sup>15sup>N<sub>2sub>; Tryptophane-<sup>15sup>N<sub>2sub>

    		 Endogenous Metabolite Metabolic Disease
    L-Tryptophan- 15N2 is the 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .
    L-Tryptophan-15N2
  • HY-W777154
    Zoledronic acid-15N2,13C2

    CGP 42446-<sup>15sup>N<sub>2sub>,<sup>13sup>C<sub>2sub>; CGP42446A-<sup>15sup>N<sub>2sub>,<sup>13sup>C<sub>2sub>; ZOL 446-<sup>15sup>N<sub>2sub>,<sup>13sup>C<sub>2sub>

    		 Isotope-Labeled Compounds Apoptosis Bacterial Autophagy Metabolic Disease
    Zoledronic acid- 15N2, 13C2 (CGP 42446- 15N2, 13C2) is the 13C- and 15N-labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .
    Zoledronic acid-15N2,13C2
  • HY-B1028S
    Pantethine-15N2

    D-Pantethine-<sup>15sup>N<sub>2sub>; LBF disulfide-<sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
    Pantethine- 15N2 is the 15N2 labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration [2] .
    Pantethine-15N2
  • HY-B0688S3
    Dapsone-15N2

    4,4′-Diaminodiphenyl sulfone-<sup>15sup>N<sub>2sub>; DDS-<sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Antibiotic Reactive Oxygen Species (ROS) Bacterial Parasite Infection Inflammation/Immunology
    Dapsone- 15N2 (4,4′-Diaminodiphenyl sulfone- 15N2) is 15N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al [2] .
    Dapsone-15N2
  • HY-A0061S
    Trifluridine-13C,15N2

    Trifluorothymidine-<sup>13sup>C,<sup>15sup>N<sub>2sub>; 5-Trifluorothymidine-<sup>13sup>C,<sup>15sup>N<sub>2sub>; TFT-<sup>13sup>C,<sup>15sup>N<sub>2sub>

    		 Thymidylate Synthase Nucleoside Antimetabolite/Analog HSV Orthopoxvirus Cancer
    Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity [2].
    Trifluridine-13C,15N2
  • HY-B1118S1
    Secnidazole-13C2, 15N2

    RP-14539-<sup>13sup>C<sub>2sub>, <sup>15sup>N<sub>2sub>; PM-185184-<sup>13sup>C<sub>2sub>, <sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Parasite Antibiotic Infection
    Secnidazole- 13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research.
    Secnidazole-13C2, 15N2
  • HY-N2362S9
    DL-Alanine-13C2,15N

    DL-2-Aminopropionic acid-<sup>13sup>C<sub>2sub>,<sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    DL-Alanine- 13C2, 15N (DL-2-Aminopropionic acid- 13C2, 15N) is 13C and 15N labeled DL-Alanine. DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver [2] .
    DL-Alanine-13C2,15N
  • HY-W770956
    Cefotiam-13C,15N2

    SCE-963-<sup>15sup>N<sub>2sub>; Cefotiam Dihydrochloride-<sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection
    Cefotiam- 13C, 15N2 (SCE-963- 13C, 15N2) is the 13C- and 15N-labeled Cefotiam (HY-B0734). Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria [2].
    Cefotiam-13C,15N2
  • HY-13599S1
    Cladribine-13C5,15N2

    2-Chloro-2′-deoxyadenosine-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>2sub>; CldAdo-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>2sub>; 2CdA-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease Cancer
    Cladribine- 13C5, 15N2 (2-Chloro-2′-deoxyadenosine- 13C5, 15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis [2].
    Cladribine-13C5,15N2
  • HY-W011240S1
    Hydroflumethiazide-15N2,13C,d2

    Methforylthiazidine-<sup>15sup>N<sub>2sub>,<sup>13sup>C,d<sub>2sub>; Rontyl-<sup>15sup>N<sub>2sub>,<sup>13sup>C,d<sub>2sub>

    		 Isotope-Labeled Compounds Others
    Hydroflumethiazide- 15N2, 13C,d2 is the 13C- and 15N-labeled Hydroflumethiazide .
    Hydroflumethiazide-15N2,13C,d2
  • HY-D0187S
    L-Glutathione reduced-13C2,15N

    GSH-<sup>13sup>C<sub>2sub>,<sup>15sup>N; γ-L-Glutamyl-L-cysteinyl-Glycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    L-Glutathione reduced- 13C2, 15N is the 13C- and 15N-labeled L-Glutathione reduced. L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
    L-Glutathione reduced-13C2,15N
  • HY-13458S1
    Droxidopa-13C2,15N hydrochloride

    L-DOPS-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride; DOPS-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride; SM5688-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride

    		 Adrenergic Receptor Isotope-Labeled Compounds Neurological Disease
    Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier [2].
    Droxidopa-13C2,15N hydrochloride
  • HY-66005S4
    Acetaminophen-13C2,15N

    Paracetamol-<sup>13sup>C<sub>2sub>,<sup>15sup>N; 4-Acetamidophenol-<sup>13sup>C<sub>2sub>,<sup>15sup>N; 4'-Hydroxyacetanilide-<sup>13sup>C<sub>2sub>,<sup>15sup>N

    		 COX Bacterial Histone Acetyltransferase Parasite Endogenous Metabolite Inflammation/Immunology
    Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen . Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent [2] . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
    Acetaminophen-13C2,15N
  • HY-D0844S
    Glutathione oxidized-13C4,15N2
    1 Publications Verification

    L-Glutathione oxidized-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>; GSSG-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>; Oxiglutatione-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Endogenous Metabolite Metabolic Disease
    Glutathione oxidized- 13C4, 15N2 is the 13C and 15N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes [2].
    Glutathione oxidized-13C4,15N2
  • HY-W699983
    Imidazole-15N2

    Glyoxaline-<sup>15sup>N<sub>2sub>; 1,3-Diaza-2,4-cyclopentadiene-<sup>15sup>N<sub>2sub>

    		 Isotope-Labeled Compounds Thrombopoietin Receptor Ser/Thr Protease Xanthine Oxidase Neurological Disease Inflammation/Immunology
    Imidazole- 15N2 (Glyoxaline- 15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease [2] .
    Imidazole-15N2
  • HY-D0184S2
    2'-Deoxycytidine-15N3

    Deoxycytidine-<sup>15sup>N<sub>3sub>; Cytosine deoxyriboside-<sup>15sup>N<sub>3sub>; Deoxyribose cytidine-<sup>15sup>N<sub>3sub>

    		 Endogenous Metabolite Others
    2'-Deoxycytidine- 15N3 is the 15N labeled 2'-Deoxycytidine . 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu) [2].
    2'-Deoxycytidine-15N3

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