2. Immunology/Inflammation
  3. FAP
  4. TriOncoFAP-GlyPro-MMAE

TriOncoFAP-GlyPro-MMAE is a small molecule drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC50 of 13 pmol/L. TriOncoFAP-GlyPro-MMAE combines a FAP-targeting ligand (TriOnco), a cleavable glycine-proline linker, and a cytotoxic payload (MMAE).

For research use only. We do not sell to patients.

TriOncoFAP-GlyPro-MMAE

TriOncoFAP-GlyPro-MMAE Chemical Structure

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TriOncoFAP-GlyPro-MMAE Related Antibodies

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Description

TriOncoFAP-GlyPro-MMAE is a small molecule drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC50 of 13 pmol/L. TriOncoFAP-GlyPro-MMAE combines a FAP-targeting ligand (TriOnco), a cleavable glycine-proline linker, and a cytotoxic payload (MMAE)[1].

Molecular Weight

3563.79

Formula

C167H218F6N36O43S
SMILES

O=C(CCC(NC1=CC=CC2=C1N=CC=C2C(NCC(N3[C@@H](CC(F)(C3)F)C#N)=O)=O)=O)NCCNC(CCOCC(NC(CCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CSC4C(N(CCCCCC(NCC(N5[C@H](C(NC6=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N7[C@](CCC7)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C8=CC=CC=C8)O)=O)=O)=O)=O)=O)C=C6)=O)CCC5)=O)=O)C(C4)=O)=O)=O)=O)=O)=O)=O)(COCCC(NCCNC(CCC(NC9=CC=CC%10=C9N=CC=C%10C(NCC(N%11CC(F)(C[C@H]%11C#N)F)=O)=O)=O)=O)=O)COCCC(NCCNC(CCC(NC%12=C(C%13=CC=C%12)N=CC=C%13C(NCC(N%14CC(F)(C[C@H]%14C#N)F)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TriOncoFAP-GlyPro-MMAE Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TriOncoFAP-GlyPro-MMAEFAPFibroblast activation proteinLigandMMAEInhibitorinhibitorinhibit

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TriOncoFAP-GlyPro-MMAE
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