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1447

Inhibitors & Agonists

6

Screening Libraries

5

Fluorescent Dye

32

Biochemical Assay Reagents

90

Peptides

23

Inhibitory Antibodies

269

Natural
Products

114

Isotope-Labeled Compounds

1

Click Chemistry

12

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125062
    Steviolmonoside

    Glucosilsteviol

    		 GLUT Metabolic Disease
    Steviolmonoside (Glucosilsteviol) is a structural analogue of steviol. Steviolmonoside decreases glucose production and inhibits oxygen uptake in rat renal cortical tubules .
    Steviolmonoside
  • HY-B0615A
    Moricizine Hydrochloride

    EN 313; Ethmozin; Moracizine

    		 Cytochrome P450 Cardiovascular Disease
    Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .
    Moricizine Hydrochloride
  • HY-A0119
    Nitroprusside disodium dihydrate
    5+ Cited Publications

    Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate

    		 Autophagy Cardiovascular Disease Cancer
    Nitroprusside disodium dehydrate (Sodium nitroprusside dihydrate) is a vasodilator that available for the research of acute hypertension, heart failure. Nitroprusside disodium dehydrate induces autophagy in glutathione-depleted osteoblasts. Nitroprusside disodium dehydrate acts as a nitric oxide (NO) donor in a rat intestinal ischemia reperfusion model .
    Nitroprusside disodium dihydrate
  • HY-N0582
    Otophylloside B

    		Amyloid-β Neurological Disease
    Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .
    Otophylloside B
  • HY-119926
    13-Hydroxylupanine

    Hydroxylupanine

    		 Integrin Cardiovascular Disease Neurological Disease
    13-Hydroxylupanine (Hydroxylupanine) is the typical alkaloid profile of sweet lupins.13-Hydroxylupanine blocks ganglionic transmission, decreases cardiac contractility and contracts uterine smooth muscle .
    13-Hydroxylupanine
  • HY-135222
    MMAI hydrochloride

    5-Methoxy-6-methyl-2-aminoindan hydrochloride

    		 5-HT Receptor Neurological Disease
    MMAI (5-Methoxy-6-methyl-2-aminoindan) hydrochloride is a selective serotonin releaser that does not produce psychoactive or hallucinogenic effects in the context of drug discrimination in rats. MMAI hydrochloride induces a behavioral syndrome in rats, including hypokinesia with freezing, spinning, Straub tail, flat posture, and reduced sleep time .
    MMAI hydrochloride
  • HY-N3486
    Isodunnianol

    		Autophagy Cardiovascular Disease
    Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity .
    Isodunnianol
  • HY-B0615AS
    Moricizine-d8(Hydrochloride)

    EN 313-d8; Ethmozin-d8; Moracizine-d8

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Moricizine-d8 (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .
    Moricizine-d8(Hydrochloride)
  • HY-16403
    Polythiazide

    		Others Cardiovascular Disease
    Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity .
    Polythiazide
  • HY-129694
    Lenoremycin

    Ro 21-6150; Antibiotic A-130-A

    		 β-catenin CDK Reactive Oxygen Species (ROS) Cancer
    Lenoremycin (Ro 21-6150) is a microbial metabolite. Lenoremycin decreases β-catenin and cyclin D1 proteins levels. Lenoremycin decreases cancer stem cells (CSCs) populations via inducing reactive oxygen species production .
    Lenoremycin
  • HY-118656
    Cannabicitran

    		Cannabinoid Receptor Neurological Disease
    Cannabicitran is a cannabinoid. Cannabicitran can decrease intraocular pressure in rabbits .
    Cannabicitran
  • HY-N0229R
    L-Alanine (Standard)

    Alanine (Standard)

    		 Reference Standards Endogenous Metabolite Neurological Disease Metabolic Disease
    L-Alanine (Standard) is the analytical standard of L-Alanine. This product is intended for research and analytical applications. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system. In Vitro: The viability of both hiPSCs, 201B7 cells and ehiPSCs decrease with an increase in L-Alanine concentration, and reach 7.5±1.3% and 3.7±0.7% respectively at 1.2 M of L-Alanine. On the other hand, no decrease in the viability of hFBs and hSkMCs are observed. Although the viability of iCMs slightly decreases along with the increase of the L-Alanine concentration, viability of iCMs at 1.2 M concentration of L-Alanine, 49.4±6.9%, is significantly higher than that of undifferentiated iPSCs, 201B7 cells and ehiPSCs (p< 0.01). The viability of hiPSCs, 201B7 cells and ehiPSCs, drastically decrease even after 2 or 4 h treatment. In contrast, the viability of hFBs fails to decrease at 1, 2, and 4 h and shows a small decrease at 24 h treatment. The viability of 201B7 cells in suspension culture decreases to 11.8±6.0% following treatment with 1.2 M L-Alanine for 2 h, whereas that of hFBs is 72.9±14.2% .
    L-Alanine (Standard)
  • HY-139576
    Larsucosterol

    DUR-928

    		 LXR Endogenous Metabolite Metabolic Disease
    Larsucosterol (DUR-928), a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol as a potent endogenous regulator decreases lipogenesis. Larsucosterol inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .
    Larsucosterol
  • HY-139576A
    Larsucosterol sodium

    DUR-928 sodium

    		 LXR Endogenous Metabolite Metabolic Disease
    Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol sodium as a potent endogenous regulator decreases lipogenesis. Larsucosterol sodium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .
    Larsucosterol sodium
  • HY-101606
    Etersalate

    Eterylate; Etherylate

    		 Prostaglandin Receptor Cardiovascular Disease Endocrinology
    Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
    Etersalate
  • HY-163794
    DC371739

    		ANGPTL PCSK9 Metabolic Disease
    DC371739 is a potent and orally activity PCSK9 inhibitor. DC371739 decreases the mRNA expression of PCSK9 and ANGPTL3. DC371739 decreases the protein expression of PCSK9 and increases the protein expression of LDLR. DC371739 has the potential for the research of hyperlipidemia .
    DC371739
  • HY-139576C
    Larsucosterol ammonium

    DUR-928 ammonium

    		 LXR Endogenous Metabolite Metabolic Disease
    Larsucosterol (DUR-928) ammonium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol ammonium as a potent endogenous regulator decreases lipogenesis. Larsucosterol ammonium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .
    Larsucosterol ammonium
  • HY-139576B
    Larsucosterol (trimethylamine)

    DUR-928 (trimethylamine)

    		 LXR Endogenous Metabolite Metabolic Disease
    Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .
    Larsucosterol (trimethylamine)
  • HY-B1319
    Pramocaine hydrochloride

    Pramoxine hydrochloride

    		 Sodium Channel Neurological Disease
    Pramocaine hydrochloride decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses.
    Pramocaine hydrochloride
  • HY-104037A
    Cintirorgon sodium

    LYC-55716 sodium

    		 ROR Cancer
    Cintirorgon sodium is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon sodium (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival .
    Cintirorgon sodium
  • HY-159518
    ROS inducer 4

    		Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis Cancer
    ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic signaling in mitochondria .
    ROS inducer 4
  • HY-158333
    Tasuldine

    		Mucin Others
    Tasuldine is a mucolytic agent, which decreases the sialomucin content of mucus, improves mucociliary and cough clearance .
    Tasuldine
  • HY-135747
    Gut restricted-7
    3 Publications Verification

    GR-7

    		 Bacterial Infection
    Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice .
    Gut restricted-7
  • HY-139324
    Cu(II)GTSM
    1 Publications Verification

    		 GSK-3 Amyloid-β Neurological Disease Cancer
    Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent .
    Cu(II)GTSM
  • HY-104037
    Cintirorgon
    5+ Cited Publications

    LYC-55716

    		 ROR Cancer
    Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival .
    Cintirorgon
  • HY-N7800
    Himbacine

    (+)-Himbacine

    		 Others Cardiovascular Disease
    Himbacine ((+)-Himbacine) is a potent antihypertensive agent. Himbacine decreases in both mean blood pressure and heart rate .
    Himbacine
  • HY-103471
    Y11

    		FAK Cancer
    Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397 and decreases tumor growth .
    Y11
  • HY-W017448
    Mepiquat chloride

    N,N-Dimethylpiperidinium chloride; PIX

    		 Biochemical Assay Reagents Others
    Mepiquat chloride (N,N-Dimethylpiperidinium chloride; PIX) is a potent plant growth regulator. Mepiquat chloride decreases plant height .
    Mepiquat chloride
  • HY-N0852
    Benzoylpaeoniflorin

    		Apoptosis Cardiovascular Disease
    Benzoylpaeoniflorin, a natural product from Chinese paeony root, has the potential for coronary heart disease by decreasing apoptosis.
    Benzoylpaeoniflorin
  • HY-108560
    (+)-Fluprostenol

    		Prostaglandin Receptor Others
    (+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1) .
    (+)-Fluprostenol
  • HY-121118
    Coronaridine
    1 Publications Verification

    		 Wnt Neurological Disease Cancer
    Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression .
    Coronaridine
  • HY-N4321
    Glucotropaeolin potassium

    Benzylglucosinolate potassium

    		 DNA/RNA Synthesis Cancer
    Glucotropaeolin potassium (Benzylglucosinolate potassium) , a glucosinolate contained in cruciferous vegetables, causes a moderate decrease in spontaneous DNA damage in animals .
    Glucotropaeolin potassium
  • HY-N0261
    Aurantio-obtusin
    1 Publications Verification

    		 TNF Receptor COX Cardiovascular Disease Inflammation/Immunology
    Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation .
    Aurantio-obtusin
  • HY-N3480
    Isogosferol

    (+)-Isogospherol; Isogospherol

    		 Others Inflammation/Immunology
    Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 .
    Isogosferol
  • HY-110216
    5J-4

    		CRAC Channel Inflammation/Immunology
    5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation .
    5J-4
  • HY-114929
    THDP17

    		Glutaminase Neurological Disease
    THDP17 is an orally active glutaminase inhibitor. THDP17 decreases ammonia production through glutaminase inhibition .
    THDP17
  • HY-113821
    1-Naphthyl phosphate potassium salt

    		Phosphatase Others
    1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor. 1-Naphthyl phosphate potassium salt decreases the splice-correcting effect .
    1-Naphthyl phosphate potassium salt
  • HY-122007
    AM-0561

    		NF-κB Cancer
    AM-0561 is a NIK inhibitor (Ki: 0.3 nM). AM-0561 decreases p52 levels .
    AM-0561
  • HY-P1494
    Substance P (1-9)

    		Neurokinin Receptor Neurological Disease
    Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.
    Substance P (1-9)
  • HY-N0465
    Olaquindox

    		Antibiotic Bacterial Infection
    Olaquindox, a quinoxalin derivative, is an orally active antibiotic. Olaquindox stimulates growth and decreases intestinal mucosal immunity of piglets .
    Olaquindox
  • HY-150412
    VU0364739

    		Phospholipase Cancer
    VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM). VU0364739 decreases cancer cell proliferation .
    VU0364739
  • HY-125088
    Oleoylestrone

    		Apoptosis Metabolic Disease
    Oleoylestrone, an adipose tissue-derived hormonal signal, is a slimming agent that decreases food intake and maintains energy expenditure .
    Oleoylestrone
  • HY-104056
    Fura Red

    		Fluorescent Dye Others
    Fura Red is a Ca 2+-sensitive fluorescent dye, which decreases in fluorescence with rising [Ca 2+] .
    Fura Red
  • HY-135066
    Triallyl pentaerythritol

    Pentaerythritol triallyl ether

    		 Biochemical Assay Reagents Others
    Triallyl pentaerythritol (PEATA), a crosslinker, decreases the protein rejection compared to membranes functionalized with MBAA or without any crosslinker .
    Triallyl pentaerythritol
  • HY-139566
    Abrucomstat
    1 Publications Verification

    3-Nitroxypropanol; 3-NOP

    		 Others Others
    Abrucomstat (3-Nitroxypropanol) is an orally active methyl coenzyme M reductase inhibitor. Abrucomstat decreases ruminal methanogenesis .
    Abrucomstat
  • HY-130361
    Isoxadifen-ethyl

    		Herbicide Others
    Isoxadifen-ethyl is a widely used herbicide safener in rice which can decrease the phytotoxicity caused by fenoxaprop-P-ethyl .
    Isoxadifen-ethyl
  • HY-P4786
    Acetyl-ACTH (7-24) (human, bovine, rat)

    		Androgen Receptor Neurological Disease Metabolic Disease
    Acetyl-ACTH (7-24) (human, bovine, rat) causes a marked decrease of ACTH-evoked corticosterone and aldosterone release .
    Acetyl-ACTH (7-24) (human, bovine, rat)
  • HY-P4253
    Arginyl-Glutamine

    		VEGFR Cardiovascular Disease
    Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .
    Arginyl-Glutamine
  • HY-168884
    AV457

    		mTOR Metabolic Disease
    AV457 is a potent and selective mTOR inhibitor with an IC50 value of 0.54 µM. AV457 inhibits cyst growth in polycystic kidney disease (PKD) organoids. AV457 decreases the protein expression of P-s6, P-p70s6 and don’t decreases the protein expression of P-AKT .
    AV457
  • HY-168483
    FTO-IN-13

    		Apoptosis Fat Mass and Obesity-associated Protein (FTO) Cancer
    FTO-IN-13 (compound 8t) is a potent FTO inhibitor. FTO-IN-13 shows antiproliferative activity. FTO-IN-13 induces apoptosis. FTO-IN-13 decreases the protein expression of Bcl-2 and Caspase 3 active. FTO-IN-13 decreases MYC and CEBPA gene expression. FTO-IN-13 shows anticancer activity .
    FTO-IN-13

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