2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. SR31527 chloride

SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation.

For research use only. We do not sell to patients.

SR31527 chloride Chemical Structure

SR31527 chloride Chemical Structure

CAS No. : 311814-78-5

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Based on 1 publication(s) in Google Scholar

SR31527 chloride Related Antibodies

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Description

SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation[1].

IC50 & Target

IC50: 6.6 µM (KIFC1)[1]
In Vitro

SR31527 chloride binds to KIFC1 with a Kd value of 25.4 nM[1].
SR31527 chloride (50 µM; 24 h) induces multiple spindle formation in MDA-MB-231, BT549 and MDA-MB-435s cells[1].
SR31527 chloride (0-100 µM; 96 h, 10-12 days) decreases the cell viability and colony formation of breast cancer cells and is less cytotoxic to LL47 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR31527 chloride Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-231, BT549, MDA-MB-435s cells
Concentration: 0-100 µM
Incubation Time: 96 h
Result: Decreased cell viability with IC50s of 29, 33, 20 µM for MDA-MB-231, BT549, MDA-MB-435s cells, respectively.
Molecular Weight

319.81

Formula

C15H14ClN3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C=C1)C2=[N+](SC(N)=N2)C3=CC=CC=C3.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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SR31527 chloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR31527311814-78-5SR 31527SR-31527KinesinantiproliferativeMDA-MB-231BT549MDA-MB-435s cellsLL47 cellsanticancerInhibitorinhibitorinhibit

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SR31527 chloride
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HY-118961
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