SR31527 chloride

Name: SR31527 chloride
Brand: MedChemExpress
SKU: HY-118961
Rating: 4.5 (1 reviews)

Cat. No.: HY-118961: Data Sheet
SDS
Handling Instructions
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SR31527 chloride is a potent KIFC1 inhibitor with an IC₅₀ value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation.

For research use only. We do not sell to patients.

SR31527 chloride Chemical Structure

CAS No. : 311814-78-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

SR31527 chloride is a potent KIFC1 inhibitor with an IC₅₀ value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation^[1].

IC₅₀ & Target

IC₅₀: 6.6 µM (KIFC1)^[1]

In Vitro

SR31527 chloride binds to KIFC1 with a K_d value of 25.4 nM^[1].
SR31527 chloride (50 µM; 24 h) induces multiple spindle formation in MDA-MB-231, BT549 and MDA-MB-435s cells^[1].
SR31527 chloride (0-100 µM; 96 h, 10-12 days) decreases the cell viability and colony formation of breast cancer cells and is less cytotoxic to LL47 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231, BT549, MDA-MB-435s cells
Concentration:	0-100 µM
Incubation Time:	96 h
Result:	Decreased cell viability with IC₅₀s of 29, 33, 20 µM for MDA-MB-231, BT549, MDA-MB-435s cells, respectively.

Molecular Weight

319.81

Formula

C₁₅H₁₄ClN₃OS

CAS No.

311814-78-5

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C=C1)C2=[N+](SC(N)=N2)C3=CC=CC=C3.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (312.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1269 mL	15.6343 mL	31.2686 mL
5 mM	0.6254 mL	3.1269 mL	6.2537 mL
10 mM	0.3127 mL	1.5634 mL	3.1269 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (276 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Zhang W, et al. Discovery of a novel inhibitor of kinesin-like protein KIFC1. Biochem J. 2016 Apr 15;473(8):1027-35. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1269 mL	15.6343 mL	31.2686 mL	78.1714 mL
	5 mM	0.6254 mL	3.1269 mL	6.2537 mL	15.6343 mL
	10 mM	0.3127 mL	1.5634 mL	3.1269 mL	7.8171 mL
	15 mM	0.2085 mL	1.0423 mL	2.0846 mL	5.2114 mL
	20 mM	0.1563 mL	0.7817 mL	1.5634 mL	3.9086 mL
	25 mM	0.1251 mL	0.6254 mL	1.2507 mL	3.1269 mL
	30 mM	0.1042 mL	0.5211 mL	1.0423 mL	2.6057 mL
	40 mM	0.0782 mL	0.3909 mL	0.7817 mL	1.9543 mL
	50 mM	0.0625 mL	0.3127 mL	0.6254 mL	1.5634 mL
	60 mM	0.0521 mL	0.2606 mL	0.5211 mL	1.3029 mL
	80 mM	0.0391 mL	0.1954 mL	0.3909 mL	0.9771 mL
	100 mM	0.0313 mL	0.1563 mL	0.3127 mL	0.7817 mL