2. Immunology/Inflammation NF-κB Anti-infection
  3. Interleukin Related NF-κB Parasite
  4. Anti-Mouse IL-9 Antibody (9C1)

Anti-Mouse IL-9 Antibody (9C1) 

Cat. No.: HY-P990208 Purity: 95.00%
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Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9 IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for research on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma.

For research use only. We do not sell to patients.

Anti-Mouse IL-9 Antibody (9C1)

Anti-Mouse IL-9 Antibody (9C1) Chemical Structure

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Anti-Mouse IL-9 Antibody (9C1) Related Antibodies

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Description

Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9 IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for research on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma[1][2][3][4].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1]

NF-κB

 

IL-9

 

In Vivo

Anti-Mouse IL-9 Antibody (9C1) (100 μg, i.p., once every 3 days, for 12 weeks) reduces activation of inflammatory pathways but exacerbates parasite proliferation in female BALB/c mice with a parasitic infection model[1].
Anti-Mouse IL-9 Antibody (9C1) (100 μg, i.p., once daily, for 5 days) effectively blocks Th9 cell-mediated allergic inflammatory response in C57BL/6 mice with sllergic reaction model[2].
Anti-Mouse IL-9 Antibody (9C1) (100 μg, i.p., once every 2 days, until the end of the experiment) significantly reduces the anti-tumor effect of Th9 cells in BALB/c mice bearing K7M2 or 4T1 tumors[3].
Anti-Mouse IL-9 Antibody (9C1) (0.5 mg, i.p., once daily, from day -1 to day 8) can improve parasitic anemia in male Swiss Albino mice with a Plasmodium berghei ANKA infected model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2000 Echinococcus granulosus injected female BALB/c mice (8-10 weeks, 20 g)[1]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days, for 12 weeks
Result: Significantly reduced the mRNA level of TLR2, NF-κB and IL-9.
Reduced inflammatory cell infiltration and fibrosis.
Exacerbated parasite proliferation and liver damage.
Animal Model: Ovalbumin (OVA) (HY-P0286) (100 μg) and TSLP (HY-P70818) (200 ng) induced C57BL/6 mice[2]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once daily, for 5 days
Result: Significantly reduced pulmonary eosinophil infiltration and inflammatory response.
Animal Model: 1×105 K7M2 or 4T1 cells injected BALB/c mice[3]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once every 2 days, until the end of the experiment
Result: Significantly reduced the inhibitory effect of Th9 cells on tumor lung metastasis.
Animal Model: 1×106 infected red blood cells injected male Swiss Albino mice (6-8 weeks, 25 g)[4]
Dosage: 0.5 mg
Administration: Intraperitoneal injection (i.p.), once daily, from day -1 to day 8
Result: Significantly increased mouse survival rate to 66.67 %.
Reduced parasitic infections and neurological symptom scores.
Reduced Th17 cell frequency and improved Th17/Treg ratio imbalance.
Downregulated the expression of pro-inflammatory cytokines such as IL-6 and IL-1β.
Gene ID

16198  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-9 Antibody (9C1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-9 Antibody (9C1) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-9 Antibody (9C1)Interleukin RelatedNF-κBParasiteILNuclear factor-κBNuclear factor-kappaBIL-9allergic reactionsparasitic4T1K7M2Inhibitorinhibitorinhibit

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