2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse/Human IL-5 Antibody (TRFK5)

Anti-Mouse/Human IL-5 Antibody (TRFK5) 

Cat. No.: HY-P990213 Purity: 95.00%
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Anti-Mouse/Human IL-5 Antibody (TRFK5) is a rat-derived anti-mouse IL-5 IgG1 κ type antibody inhibitor. Anti-Mouse/Human IL-5 Antibody (TRFK5) can significantly decrease eosinophils. Anti-Mouse/Human IL-5 Antibody (TRFK5) shows potent anti- inflammation effect on pulmonary inflammation and asthma.

For research use only. We do not sell to patients.

Anti-Mouse/Human IL-5 Antibody (TRFK5) Chemical Structure

Anti-Mouse/Human IL-5 Antibody (TRFK5) Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Anti-Mouse/Human IL-5 Antibody (TRFK5) Related Antibodies

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Description

Anti-Mouse/Human IL-5 Antibody (TRFK5) is a rat-derived anti-mouse IL-5 IgG1 κ type antibody inhibitor. Anti-Mouse/Human IL-5 Antibody (TRFK5) can significantly decrease eosinophils. Anti-Mouse/Human IL-5 Antibody (TRFK5) shows potent anti- inflammation effect on pulmonary inflammation and asthma[1][2][3][4].

IC50 & Target

IL-5
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Human IL-5 Antibody (TRFK5) Related Antibodies
In Vivo

Anti-Mouse/Human IL-5 Antibody (TRFK5) (4 mg/kg, i.p., every day until killed at day 10) reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma [1].
Anti-Mouse/Human IL-5 Antibody (TRFK5) (1 mg/kg, 1 day before myocardial infarction surgery) abolished fully the protection of IL-5 for myocardial infarction by depleting eosinophils[2].
Anti-Mouse/Human IL-5 Antibody (1 mg/kg, i.p., a single dose) inhibits pulmonary and blood eosinophilia in Pulmonary inflammation mice models[3].
Anti-Mouse/Human IL-5 Antibody (100 µg, intranasally, a single dose) significantly attenuates pulmonary eosinophilic inflammation and airway hyperresponsiveness[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic asthma micemodels (C57BL/6, female, 6-10 week)[1]
Dosage: 4 mg/kg
Administration: Intraperitoneally injection, every day until killed at day 10
Result: Showed a dramatic reduction in the absolute number of eosinophils recovered in BAL fluid.
Significantly increased lymphocytosis in BAL fluid.
Exhibited airway hyperresponsiveness (AHR).
Animal Model: Myocardial infarction mice models(C57BL/6, male, 8-10 week)[2]
Dosage: 1 mg/kg
Administration: 1 day before myocardial infarction surgery
Result: Significant reduced cardiac function and wall thickness, and increased of infarct size.
Muted the inhibitive effects of IL-5 on CD206+ macrophage polarization.
Blocked STAT6 phosphorylation.
Animal Model: Pulmonary inflammation mice models (B6D2F1, male, 6-10 weeks)[3]
Dosage: 1 mg/kg
Administration: Intraperitoneally injection
Result: Significantly inhibited eosinophil recruitment into BALF.
Inhibited the reduction of eosinophils in the bone marrow.
Animal Model: IL-5-induced blood eosinophilia mice models (B6D2F1, male, 6-10 weeks)[3]
Dosage: 1 mg/kg
Administration: Intraperitoneally injection
Result: Significantly reduced blood eosinophilia.
Exhibited a dramatic increase in the number of T cells in BALF after 24 weeks.
Increased IL-5 mRNA levels in the lungs.
Animal Model: Asthma mice models[4]
Dosage: 100 µg
Administration: Intranasally
Result: Decreased total number of cells and the percentage of eosinophils recovered from BALF.
Showed a significant reduction in the magnitude of the lung tissue inflammatory cell infiltration elicited.
Showed lower Rrs responses to methacholine.
Showed higher average values for PD100 and MR.
Gene ID

16191  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Human IL-5 Antibody (TRFK5)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse/Human IL-5 Antibody (TRFK5) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human IL-5 Antibody (TRFK5)Interleukin RelatedILIL-5Chronic asthmaEosinophilsMyocardial infarctiPulmonary inflammationInhibitorinhibitorinhibit

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