2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis SHP2
  4. TK-684

TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, ＞1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK.

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TK-684 Chemical Structure

TK-684 Chemical Structure

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TK-684 Related Antibodies

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Description

TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, ＞1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK[1].

In Vitro

TK-684 (1.25-100 μM; 72 h) inhibits cell proliferative in KYSE-150 cells[1].
TK-684 (0-40 μM; 48 h) induces apoptosis[1].
TK-684 (0-20 μM; 2 h) decreases the protein expression of p-AKT, p-ERK in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TK-684 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: KYSE-150 cells
Concentration: 1.25-100 μM
Incubation Time: 72 h
Result: Inhibited cell proliferative.

Apoptosis Analysis[1]

Cell Line: KYSE-150 cells
Concentration: 0-40 μM
Incubation Time: 48 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: KYSE-150 cells
Concentration: 0-20 μM
Incubation Time: 2 h
Result: Decreased the protein expression of p-AKT, p-ERK in a dose-dependent manner.
Parmacokinetics
Species Dose Route Indicator value
Rat 10 mg/kg p.o. T1/2 (Metabolic) 2.41 hr
Rat 10 mg/kg p.o. F 0.9 %
Molecular Weight

420.92

Formula

C17H21ClN8OS
SMILES

ClC1=C(N=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TK-684 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK-684TK684TK 684ApoptosisSHP2Src homology phosphatase 2PTPN11KYSE-150 cellsapoptosisp-AKTp-ERKproliferationInhibitorinhibitorinhibit

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