2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism
  4. (3S,4R)-ME-344

(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 (HY-112749). ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research.

For research use only. We do not sell to patients.

(3S,4R)-ME-344

(3S,4R)-ME-344 Chemical Structure

CAS No. : 1374524-84-1

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(3S,4R)-ME-344 Related Antibodies

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Description

(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 (HY-112749). ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research[1].

Molecular Weight

348.39

Formula

C22H20O4
CAS No.
SMILES

CC1=C2C([C@@H](C3=CC=C(C=C3)O)[C@@H](C4=CC=C(C=C4)O)CO2)=CC=C1O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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(3S,4R)-ME-344 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3S,4R)-ME-3441374524-84-1Heme Oxygenase (HO)Reactive Oxygen Species (ROS)Mitochondrial MetabolismHeme Oxygenase(3S,4R)-enantiomerHO-1InhibitorROSATPRedox homeostasisMitochondrial functionAntitumorH460 cellsSHP-77 cellsBreast cancerinhibitorinhibit

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