2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase
  4. Mitoquinol

Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs.

For research use only. We do not sell to patients.

Mitoquinol Chemical Structure

Mitoquinol Chemical Structure

CAS No. : 845959-55-9

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Based on 1 publication(s) in Google Scholar

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Mitoquinol Related Antibodies

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Description

Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs[1][2][3].

In Vitro

Mitoquinol (150-500 nM; 30 min-18 h) reduces the oxygen consumption rate associated with ATP production (IC50: 189 nM), increases mitochondrial proton leak, basal oxygen consumption rate, superoxide anion and H2O2 production, and enhances glycolysis in bovine aortic endothelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mitoquinol Related Antibodies

Immunofluorescence[1]

Cell Line: Bovine aortic endothelial cells
Concentration: 200 and 300 nM
Incubation Time: Overnight exposure
Result: Enhanced superoxide production as demonstrated by fluorescence of the mitochondrial-targeted dihydroethidium probe MitoSOX.
In Vivo

Mitoquinol (40 mg/d; oral administration; twice daily; 3 days) exerts ameliorative effects against heat stress in crossbred barrows[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crossbred barrows (59.0±5.6 kg) treated acute heat stress[2]
Dosage: 40 mg/d
Administration: Oral administration; twice daily; 3 days
Result: Partially ameliorated the negative effects of acute heat stress on animal performance, inflammation, and metabolism, as evidenced by increased feed intake, attenuated body weight loss, increased blood glucose, and decreased circulating non-esterified fatty acids in heat-stressed pigs compared to heat-stressed controls.
Clinical Trial
Molecular Weight

680.83

Formula

C38H49O7PS
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC1=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(O)=C(OC)C(OC)=C1O.CS(=O)([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (44.06 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4688 mL 7.3440 mL 14.6880 mL
5 mM 0.2938 mL 1.4688 mL 2.9376 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.00%

SDS (251 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4688 mL 7.3440 mL 14.6880 mL 36.7199 mL
5 mM 0.2938 mL 1.4688 mL 2.9376 mL 7.3440 mL
10 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6720 mL
15 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
20 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8360 mL
25 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
30 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
40 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
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Mitoquinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitoquinol845959-55-9Reactive Oxygen Species (ROS)HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHantioxidantreduced form of mitoquinoneH2O2crossbred barrowsacute heat stressInhibitorinhibitorinhibit

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