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Results for "

53

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MDM-2/p53 (314) 17β-HSD (2) 5 alpha Reductase (1) 5-HT Receptor (10) Acetyl-CoA Carboxylase (2) Acyltransferase (1) ADC Payload (1) Adenosine Receptor (3) Adrenergic Receptor (3) Akt (18) Amino Acid Derivatives (1) Aminopeptidase (2) AMPK (4) Amylases (3) Amyloid-β (1) Androgen Receptor (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (12) Antifolate (1) AP-1 (3) Apical Sodium-Dependent Bile Acid Transporter (4) Apoptosis (240) Aryl Hydrocarbon Receptor (3) Atg8/LC3 (1) ATM/ATR (5) Aurora Kinase (2) Autophagy (37) Bacterial (24) Bcl-2 Family (28) BCL6 (1) Beta-lactamase (1) Beta-secretase (2) Biochemical Assay Reagents (10) BMI1 (1) BMX Kinase (1) Btk (2) c-Fms (2) c-Kit (1) c-Myc (2) Calcium Channel (6) Cannabinoid Receptor (2) Carbonic Anhydrase (2) Carboxylesterase (CES) (2) Casein Kinase (7) Caspase (36) Cathepsin (3) CCR (1) CDK (20) CETP (1) Checkpoint Kinase (Chk) (5) Chloride Channel (1) Cholinesterase (ChE) (5) CMV (1) Complement System (1) COX (15) Cryptochrome (1) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (2) Cytochrome P450 (13) Deubiquitinase (13) Dihydroorotate Dehydrogenase (3) Dipeptidyl Peptidase (1) Discoidin Domain Receptor (1) DNA Alkylator/Crosslinker (3) DNA Methyltransferase (3) DNA/RNA Synthesis (31) Dopamine Receptor (2) Dopamine Transporter (1) Drug Derivative (4) Drug Intermediate (3) Drug Isomer (2) Drug Metabolite (4) Drug-Linker Conjugates for ADC (2) Dystrophin (3) E1/E2/E3 Enzyme (39) E3 Ligase Ligand-Linker Conjugates (3) EAAT (1) Early 2 Factor (E2F) (1) EBI2/GPR183 (1) EGFR (16) Endogenous Metabolite (27) Endonuclease (1) Endothelin Receptor (2) Enolase (1) Enterovirus (1) Epigenetic Reader Domain (8) Epoxide Hydrolase (2) ERK (9) Estrogen Receptor/ERR (4) FAAH (1) FAK (2) Ferroptosis (14) FGFR (1) Flavivirus (1) FLT3 (2) Fluorescent Dye (3) Free Fatty Acid Receptor (1) Fungal (12) FXR (1) GABA Receptor (3) Galectin (2) GCGR (1) GLP Receptor (1) Glucocorticoid Receptor (1) GLUT (1) Glutaminase (3) Glutathione Peroxidase (4) Glycosidase (5) GnRH Receptor (1) GPR109A (1) GPR35 (2) GPR52 (1) GPR88 (1) GSK-3 (3) HBV (4) HCV (2) HCV Protease (1) HDAC (15) Herbicide (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (13) Histamine Receptor (3) Histone Acetyltransferase (4) Histone Demethylase (3) Histone Methyltransferase (3) HIV (6) HIV Protease (3) HMG-CoA Reductase (HMGCR) (2) HSP (6) HSV (1) ICMT (2) iGluR (5) IKK (1) IKZF Family (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (3) Insulin Receptor (1) Integrin (4) Interleukin Related (12) IRAK (2) Isotope-Labeled Compounds (35) Itk (1) JAK (3) JNK (16) Lactate Dehydrogenase (2) Leukotriene Receptor (3) Ligands for E3 Ligase (5) Ligands for Target Protein for PROTAC (1) Lipoxygenase (3) LPL Receptor (1) LRRK2 (1) LXR (1) MAGL (1) MAP3K (1) MAP4K (2) MAPKAPK2 (MK2) (1) MEK (5) mGluR (1) MHC (1) MicroRNA (1) Microtubule/Tubulin (17) Mitochondrial Metabolism (3) Mitophagy (6) Mitosis (2) Mixed Lineage Kinase (1) MMP (5) Molecular Glues (6) Monoamine Oxidase (2) mRNA (2) mTOR (6) MyD88 (1) nAChR (7) Necroptosis (1) Neuropeptide FF Receptor (1) NF-κB (22) NO Synthase (7) NOD-like Receptor (NLR) (4) Notch (2) Nuclear Factor of activated T Cells (NFAT) (5) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (7) Oct3/4 (1) OGT (1) Opioid Receptor (1) Orexin Receptor (OX Receptor) (4) Organoid (2) P-glycoprotein (1) p38 MAPK (17) PAI-1 (1) Pantetheinase (1) Parasite (21) PARP (11) PD-1/PD-L1 (3) PDK-1 (1) Penicillin-binding protein (PBP) (1) PERK (3) Phosphatase (6) Phosphodiesterase (PDE) (3) Phosphoglycerate Dehydrogenase (PHGDH) (1) Phosphorylase (1) PI3K (6) PI4K (1) Pim (1) PKC (3) PKD (2) Polo-like Kinase (PLK) (3) Potassium Channel (5) PPAR (3) Prostaglandin Receptor (6) PROTACs (18) Proteasome (6) Protein Arginine Deiminase (2) PTEN (3) Pyroptosis (2) RAD51 (2) Raf (2) RANKL/RANK (2) RAR/RXR (1) Ras (4) Reactive Oxygen Species (ROS) (28) Reference Standards (32) RET (2) Reverse Transcriptase (3) RIP kinase (3) ROCK (1) ROR (1) ROS Kinase (2) RSV (2) SARS-CoV (13) Ser/Thr Kinase (1) Ser/Thr Protease (1) SGLT (1) SHMT (1) Sigma Receptor (1) Sirtuin (15) Small Interfering RNA (siRNA) (29) SOD (5) SOS1 (1) Src (2) STAT (9) STING (3) Survivin (1) Syk (1) TAM Receptor (2) TGF-β Receptor (8) Thyroid Hormone Receptor (1) TNF Receptor (10) Toll-like Receptor (TLR) (7) Topoisomerase (4) Transmembrane Glycoprotein (6) Trk Receptor (1) TRP Channel (2) Tryptophan Hydroxylase (1) TSH Receptor (1) Tyrosinase (3) Vasopressin Receptor (1) VD/VDR (1) VEGFR (4) Virus Protease (2) VISTA (1) Wnt (5) Xanthine Oxidase (4) YAP (1) α-synuclein (2) β-catenin (6)
By Research Areas:	Cancer (617) Cardiovascular Disease (39) Endocrinology (24) Infection (94) Inflammation/Immunology (135) Metabolic Disease (60) Neurological Disease (80)
Click Chemistry:	Azide (4) Alkynes (2)
Oligonucleotides:	Nucleoside Analogs (3) Uridine (2) Rat Pre-designed siRNA Sets (5) mRNA (2) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (19) siRNA drugs (2) Polymers (1) Antisense Oligonucleotides (4) Cytidine (1) Cholesterol (1) siRNAs (29)

917

Inhibitors & Agonists

Screening Libraries

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Peptides

MCE Kits

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Isotope-Labeled Compounds

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PMX-53 4 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

5-(3-Iodopropoxy)-2-nitrobenzenemethanol	Biochemical Assay Reagents	Others
5-(3-Iodopropoxy)-2-nitrobenzenemethanol is a biochemical reagent.

5-(3-Hydroxybenzylidene)-rhodanine	Drug Derivative	Others
5-(3-Hydroxybenzylidene)-rhodanine, a derivative of rhodanine, can be used as an algicidal agent .

5-(3-hydroxyphenyl)-5-phenylhydantoin	Drug Metabolite	Others
5-(3-hydroxyphenyl)-5-phenylhydantoin, is a metabolite of anti-seizure agent Phenytoin .

5-(3'-Hydroxyphenyl)-γ-valerolactone 3′-OH-PVL	Endogenous Metabolite	Metabolic Disease
5-(3'-Hydroxyphenyl)-γ-valerolactone is a flavan-3-ols metabolitec of human faecal microbiota .

5-(3-Azidopropyl)uridine	Nucleoside Antimetabolite/Analog	Cancer
5-(3-Azidopropyl)uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis . 5-(3-Azidopropyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

7-Methoxy-5-benzofuranpropanol 5-(3-Hydroxypropyl)-7-methoxybenzofuran	Others	Others
7-Methoxy-5-benzofuranpropanol (5-(3-Hydroxypropyl)-7-methoxybenzofuran) is a Chalcones product that can be isolated from the roots of Lindera strychnifolia .

5-(3-Azidopropyl)cytidine	Nucleoside Antimetabolite/Analog	Others
5-(3-Azidopropyl)cytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities . 5-(3-Azidopropyl)cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Anticancer agent 53	Apoptosis	Cancer
Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity .

Antifungal agent 53	Fungal	Infection
Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety .

YH-53	SARS-CoV	Infection
YH-53 is a potent 3CL ^pro inhibitor with K_i values of 6.3 nM, 34.7 nM for SARS-CoV-1 3CL ^pro and SARS-CoV-2 3CL ^pro, respectively. YH-53 strongly blocks the SARS-CoV-2 replication. YH-53 is a peptidomimetic compound with a unique benzothiazolyl ketone. YH-53 has the potential for COVID-19 research .

ReACp53 2 Publications Verification	MDM-2/p53	Cancer
ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.

OSU-53	AMPK mTOR Autophagy Atg8/LC3	Cancer
OSU-53 is an orally active AMPK activator (EC₅₀: 0.3 μM) and a direct mTOR inhibitor. OSU-53 induces autophagy and increases conversion of LC3 I to LC3 II. OSU-53 also modulates energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of PGC1α and NRF-1. OSU-53 has antitumor activity in various tumor models, such as breast cancer and thyroid cancer .

p53 CBS p53 Consensus binding sequence	MDM-2/p53	Others
p53 CBS (p53 Consensus binding sequence) is a biological active peptide. (p53 consensus DNA binding site)

Antitumor agent-53	Apoptosis	Cancer
Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors .

PMX 53 monoacetate 3D53 monoacetate	Endogenous Metabolite	Inflammation/Immunology
PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC₅₀ value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC₅₀ value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2 .

STR-V-53	HDAC	Cancer
STR-V-53 is an HDAC inhibitor (IC₅₀ in nM).STR-V-53 increases histone acetylation in tumor cells by inhibiting the activity of these enzymes, which in turn regulates gene expression.STR-V-53 inhibits tumor growth, and induces apoptosis .

Tubulin-IN-53	Microtubule/Tubulin Apoptosis Reactive Oxygen Species (ROS)	Cancer
Tubulin-IN-53 is a potent Tubulin inhibitor with an IC₅₀ of 6.06 μM. Tubulin-IN-53 inhibits the polymerization of tubulin by targeting the colchicine binding site of tubulin and destroys the microtubule network. Tubulin-IN-53 induces MCF-7 cell cycle arrest in the G2/M phase and apoptosis, and inhibits cell migration accompanied by the decrease of mitochondrial membrane potential and increase the accumulation of ROS. Tubulin-IN-53 destroys the angiogenesis of human umbilical vein endothelial cells.Tubulin-IN-53 can used for the study of cancers such as breast cancer and lung cancer .

EGFR-IN-53	EGFR	Cancer
EGFR-IN-53 (Compound 7) is a potent EGFR inhibitor with an IC₅₀ of 8.264 µM. EGFR-IN-53 shows cytotoxic activity against cancer cell lines .

SLMP53-2	MDM-2/p53 Apoptosis	Cancer
SLMP53-2 is a mutant *p53* reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity .

HDAC-IN-53	HDAC Apoptosis	Cancer
HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC₅₀ values of 47 nM, 125 nM, and 450 nM, respectively. HDAC-IN-53 does not inhibit class II HDACs (HDAC4, 5, 6, 7, 9; IC₅₀>10 μM). HDAC-IN-53 induces caspase-dependent apoptosis. HDAC-IN-53 significantly inhibits the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice bearing MC38 colon cancer .

MG-V-53	VISTA	Cancer
MG-V-53 is a potent small molecule V domain T-cell activating immunoglobulin suppressor (VISTA) inhibitor with IC₅₀ value of 121 nM. MG-V-53 has antitumor activity .

TP53 neoepitope	MHC	Cancer
TP53 neoepitope is a high-affinity antigenic peptide targeting HLA-A. TP53 neoepitope can triggers CD8 ⁺ T cell-mediated killing of TP53-mutant tumor cells. TP53 neoepitope is promising for research of solid tumors harboring TP53 hotspot mutations (e.g., R175H, R273H) .

P53R3	MDM-2/p53	Cancer
P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53 ^R175H, p53 ^R248W and p53 ^R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 ^M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research .

DJ-53	Epoxide Hydrolase	Cancer
DJ-53 (compund 68) is an orally active phenylquinoline-based soluble epoxide hydrolase inhibitor .

ZK53	Mitochondrial Metabolism	Cancer
ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC₅₀: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model .

VEGFR-2-IN-53	VEGFR Apoptosis	Cancer
VEGFR-2-IN-53 (Compound 15w) is a VEGFR-2 inhibitor with an IC₅₀ of 4.34 μM. VEGFR-2-IN-53 induces apoptosis by inhibiting VEGFR-2 activity and preventing cell migration, thereby exhibiting anti-angiogenic effects. The IC₅₀ value of VEGFR-2-IN-53 for inhibiting MCF-7 cell growth is 3.87 μM. VEGFR-2-IN-53 can be used in cancer research .

Tubulin polymerization-IN-53	Microtubule/Tubulin	Others
Tubulin polymerization-IN-53 (compound 4b) is an inhibitor of β-tubulin polymerization. Tubulin polymerization-IN-53 can arrest the cell cycle at the G2/M stage. Tubulin polymerization-IN-53 has antiproliferative efficacy against the MDA-MB-231 cell line with an IC₅₀ value of 3.24 μM .

COX-2-IN-53	COX	Inflammation/Immunology
COX-2-IN-53 (compound 9) is a potent COX-2 inhibitor with an IC₅₀ of 0.373 μM. COX-2-IN-53 reduces radiation-induced oxidative stress .

ICMT-IN-53	ICMT	Cancer
ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC₅₀=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC₅₀s of 5.14 μM and 5.88 μM, respectively .

UCM53	Bacterial	Infection
UCM53, a FtsZ inhibitor, is an antibacterial agent. UCM53 can inhibit the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis

Pigment Red 53 Lake Red C	Endogenous Metabolite
Pigment Red 53 (Lake Red C) is an organic pigment with good color stability and spectral properties. Pigment Red 53 is widely used in the coatings and plastics industries to provide a vivid red color. Pigment Red 53 is also used in food and cosmetics as a safe colorant to ensure an attractive product appearance.

HIV-1 inhibitor-53	HIV Protease Reverse Transcriptase	Infection Inflammation/Immunology
HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC₅₀ values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .

SLMP53-1	MDM-2/p53	Cancer
SLMP53-1 is a wild-type and mutant *p53* reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels .

p53 Stabilizer 2	MDM-2/p53 Apoptosis Checkpoint Kinase (Chk)	Cancer
p53 Stabilizer 2 (Compound 17a16) is a *p53* stabilizer. p53 Stabilizer 2 induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells. p53 Stabilizer 2 induces mitochondrial stress and activates two checkpoint pathways: NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. p53 Stabilizer 2 inhibits tumor growth in p53-deficient xenograft model .

TG53	Glutaminase Integrin FAK Src	Cancer
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research .

MDM2-p53-IN-16	MDM-2/p53	Cancer
MDM2-p53-IN-16 is a *MDM2-p53* complex inhibitor with an IC₅₀ value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research .

ReACp53 scrambled peptide	MDM-2/p53	Cancer
ReACp53 scrambled peptide is a negative control for ReACp53 (HY-P0121). ReACp53 scrambled peptide can be used in the study of ovarian cancer .

p53 (17-26)	MDM-2/p53	Cancer
p53 (17-26) is amino acids 17 to 26 fragment of p53. p53 (17-26) is mdm-2-binding domain .

Intermedin1-53 (Human)	Apoptosis	Cardiovascular Disease
Intermedin1-53 (Human) is a 53-aa human calcitonin family peptide that reduces the vulnerability of atherosclerotic plaques by inhibiting CHOP-mediated macrophage apoptosis and inflammasome .

PRL-8-53	Drug Derivative	Neurological Disease
PRL-8-53 is a derivative of 2-PhenylethylaMine. PRL-8-53 is an orally active psychotropic agent .

AChE-IN-53	iGluR	Neurological Disease
AChE-IN-53 (Compound I-52) is a potent NMDAR inhibitor, which is a compound with favorable behavioral and neuroprotective effects .

p53-MDM2-IN-6	MDM-2/p53 Apoptosis	Cancer
p53-MDM2-IN-6 (Compound 10a), a LSM-83177 hydrazone analog, is a potent *p53-MDM2* inhibitor with an IC₅₀ value of 11.08 µg/mL. p53-MDM2-IN-6 arrests the cell cycle in the S phase and induces early and late Apoptosis with antiproliferative activity against HT29 cell lines with an IC₅₀ value of 10.44 µg/mL. p53-MDM2-IN-6 inhibits p53-MDM2 interaction with increment in p-53 level and decrease the expression of GST enzymes. p53-MDM2-IN-6 is promising for research of colorectal cancer .

p53 Activator 12	MDM-2/p53	Cancer
p53 Activator 12 (compound 510B) is a potent *p53* activator. p53 Activator 12 binds to mutant p53 and restores the ability of the p53 mutant to bind DNA .

p53-MDM2-IN-5	Apoptosis Autophagy MDM-2/p53	Cancer
p53-MDM2-IN-5 (compound 5a) is a potent *p53-MDM2* inhibitor. p53-MDM2-IN-5 induces apoptosis, autophagy and DNA damage. p53-MDM2-IN-5 induces cell cycle arrest at S and G2/M phases. p53-MDM2-IN-5 shows anti-tumor activity .

MDM2-p53-IN-15	MDM-2/p53 Apoptosis	Cancer
MDM2-p53-IN-15 is a *MDM2-p53* inhibitor with an IC₅₀ value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer .

Cat. No.	Product Name

HY-L077

Anti-Pancreatic Cancer Compound Library

3,563 compounds

Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer.

MCE offers a unique collection of 3,563 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

HY-L097

Animal Disease Model Inducer Library

53 compounds

Animal disease models are used in a variety of settings in basic research, such as studies on mechanisms of disease progression and evaluation new drugs. Animal models can be broadly classified into five categories: 1) experimental, 2) spontaneous, 3) negative, 4) orphan, 5) genetically engineered. Experimental models, which are induced artificially in the laboratory, are most common. Some small molecular compounds are usually used as inducers for animal models, such as Ceruletide for inflammatory model, Azoxymethane for tumor model. These inducers are useful tool in building animal models.

MCE offers a unique collection of 53 animal model inducers, involving inflammatory model, tumor model, nervous disease model, etc. MCE Animal Disease Model library is a powerful tool for the establishment of animal disease models.

HY-L034

Anti-Aging Compound Library

6,223 compounds

Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

MCE Anti-Aging Compound Library contains 6,223 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

HY-L003

Apoptosis Compound Library

3,084 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 3,084 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

HY-L109

Protein-protein Interaction Inhibitor Library

686 compounds

Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs.

However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.

With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 686 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.

HY-L051

Ferroptosis Compound Library

969 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 969 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

HY-L103

Anti-Colorectal Cancer Compound Library

2,129 compounds

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer.

Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 2,129 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-D1072

DiOC5(3) 3,3′-Dipentyloxacarbocyanine iodide	Fluorescent Dyes/Probes
DiOC5(3) is the membrane potential (MP)-modifying fluorochrome. DiOC5(3) is an anti-LSC compound available for diagnostic imaging. DiOC5(3) has the advantage of being a single fluorescent chemical .

HY-19980G

Eprenetapopt (GMP) APR-246 (GMP); PRIMA-1Met (GMP)	Fluorescent Dye
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

Cat. No.	Product Name	Type

HY-B1102

Evans Blue

20+ Cited Publications

Direct Blue 53; T-1824; C.I. 23860

Cell Assay Reagents

Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .

HY-126437

Poly-L-lysine hydrobromide (MW 30000-70000)

1 Publications Verification

Drug Delivery

Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material .

HY-D0848

N,N'-Methylenebisacrylamide

Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide

Thickeners

N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel .

HY-W967441

5-(3-Iodopropoxy)-2-nitrobenzenemethanol	Biochemical Assay Reagents
5-(3-Iodopropoxy)-2-nitrobenzenemethanol is a biochemical reagent.

HY-19980G

Eprenetapopt (GMP) APR-246 (GMP); PRIMA-1Met (GMP)	Biochemical Assay Reagents
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

Cat. No.	Product Name	Target	Research Area

HY-106178

PMX-53 4 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-P0121

ReACp53 2 Publications Verification	MDM-2/p53	Cancer
ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.

HY-P0121B

ReACp53 scrambled peptide TFA	MDM-2/p53	Cancer
ReACp53 scrambled peptide TFA is a negative control for ReACp53 (HY-P0121). ReACp53 scrambled peptide can be used in the study of ovarian cancer .

HY-P5343

p53 CBS p53 Consensus binding sequence	MDM-2/p53	Others
p53 CBS (p53 Consensus binding sequence) is a biological active peptide. (p53 consensus DNA binding site)

HY-P11089

TP53 neoepitope	MHC	Cancer
TP53 neoepitope is a high-affinity antigenic peptide targeting HLA-A. TP53 neoepitope can triggers CD8 ⁺ T cell-mediated killing of TP53-mutant tumor cells. TP53 neoepitope is promising for research of solid tumors harboring TP53 hotspot mutations (e.g., R175H, R273H) .

HY-P0121A

ReACp53 scrambled peptide	MDM-2/p53	Cancer
ReACp53 scrambled peptide is a negative control for ReACp53 (HY-P0121). ReACp53 scrambled peptide can be used in the study of ovarian cancer .

HY-P1755

p53 (17-26)	MDM-2/p53	Cancer
p53 (17-26) is amino acids 17 to 26 fragment of p53. p53 (17-26) is mdm-2-binding domain .

HY-P11289

Intermedin1-53 (Human)	Apoptosis	Cardiovascular Disease
Intermedin1-53 (Human) is a 53-aa human calcitonin family peptide that reduces the vulnerability of atherosclerotic plaques by inhibiting CHOP-mediated macrophage apoptosis and inflammasome .

HY-P10295

p53 (232-240)	MDM-2/p53	Cancer
p53 (232-240) is a peptide segment of the 232-240 amino acid sequence of the human tumor suppressor protein p53. p53 (232-240) enhances its binding affinity to the Major histocompatibility complex (MHC), thereby enhancing the immunogenicity of this peptide to enhance the immune system's response to tumor antigens. p53 (232-240) can be used in the development of cancer vaccines and in the study of tumor cell recognition and clearance by the immune system .

HY-P3605

GnRH Associated Peptide (25-53), human GAP (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P5490

Spexin-2 (53-70), human,mouse,rat NPQ 53-70	Peptides	Others
Spexin-2 (53-70), human,mouse,rat (NPQ 53-70) is a biological active peptide. (This is Spexin-2 (53-70), non-amidated version of the novel peptide hormone that is derived from prohormone proNPQ and is conserved amongst mammalian species. It is a central modulator of cardiovascular and renal function. Spexin-2, when administered to rats, decreases heart rate and increases urine flow rate)

HY-P10982

SjDX5-53	Toll-like Receptor (TLR)	Inflammation/Immunology
SjDX5-53 is a selective TLR2 inducer derived from a 3 kDa peptide from Schistosoma japonicum eggs. SjDX5-53 inhibits inflammatory Th1 and Th17 responses by inducing tolerogenic dendritic cells (tolDCs) and promoting the generation of regulatory T cells (Tregs) and their suppressive capacity. SjDX5-53 is primarily used in the treatment of autoimmune and inflammatory diseases such as colitis and psoriasis .

HY-P11014

SjDX5-53 control peptide	Toll-like Receptor (TLR)	Inflammation/Immunology
SjDX5-53 control peptide is a control peptide of the TLR2 activator SjDX5-53 (HY-P10982) that does not target a specific receptor and does not modulate regulatory T cells (Tregs) or dendritic cells. SjDX5-53 control peptide can be used to exclude nonspecific effects and help verify the specific role of SjDX5-53 in inducing Tregs and alleviating autoimmune diseases. SjDX5-53 control peptide is used in the study of autoimmune diseases such as colitis and psoriasis .

HY-P4700

pTH (53-84) (human)	Thyroid Hormone Receptor	Endocrinology
pTH (53-84) (human) is apTH ((Human parathyroid hormone) fragment.

HY-P11036

p53-hDM2 cyclic peptide inhibitor 16e	MDM-2/p53	Cancer
p53-hDM2 cyclic peptide inhibitor 16e is a *p53-hDM2* cell-permeable peptide inhibitor with an IC₅₀ of 9.24 nM for hDM2. p53-hDM2 cyclic peptide inhibitor 16e can be used for cancers like breast, colorectal and cervical cancers research .

HY-P1755F

p53 (17-26), FITC labeled	MDM-2/p53	Others
p53 (17-26), FITC labeled is a biological active peptide.

HY-P2479

Peripheral Myelin Protein P2 (53-78), bovine	Peptides	Inflammation/Immunology
Peripheral Myelin Protein P2 (53-78), bovine is derived from bovine peripheral myelin P2 protein amino acid residues 53-78. Peripheral Myelin Protein P2 (53-78), bovine is a T cell epitope for the induction of experimental autoimmune neuritis (EAN) in Lewis rats .

HY-P3343A

hFSH-β-(33-53) (TFA) 1 Publications Verification	Estrogen Receptor/ERR	Cancer
hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells .

HY-P1815

C-Type Natriuretic Peptide (1-53), human	Angiotensin Receptor	Cardiovascular Disease Endocrinology
C-Type Natriuretic Peptide (1-53), human is the 1-53 fragment of C-Type Natriuretic Peptide. C-Type Natriuretic Peptide is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone .

HY-P1019

[Ala1,3,11,15]-Endothelin (53-63)	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction

HY-P3976

Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is a blood pressure lowering peptide containing 4 amino acids. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is an angiotensin-converting Enzyme (ACE) inhibitor. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine can be used in research of high blood pressure .

HY-P1815A

C-Type Natriuretic Peptide (1-53), human TFA	Angiotensin Receptor	Cardiovascular Disease Endocrinology
C-Type Natriuretic Peptide (1-53), human TFA is the 1-53 fragment of C-Type Natriuretic Peptide. C-Type Natriuretic Peptide TFA is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone .

HY-P1019A

[Ala1,3,11,15]-Endothelin (53-63) (TFA)	Endothelin Receptor	Cardiovascular Disease Endocrinology
[Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ET ^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction .

HY-P10720

C-Type Natriuretic Peptide (1-53), Porcine, Rat,mouse	Endogenous Metabolite	Cardiovascular Disease
C-Type Natriuretic Peptide (1-53), Porcine, Rat, mouse is an activator of particulate guanylate cyclase B (pGC-B), which is highly expressed in endothelial cells, kidneys, and the heart. C-Type Natriuretic Peptide (1-53), Porcine, Rat, mouse can mediate a potent anti-fibrotic effect in human cardiac and renal fibroblasts by generating the second messenger cGMP .

HY-P4210

Sulanemadlin ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-P10286

Phage-derived 12/1 peptide	MDM-2/p53	Cancer
Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC₅₀ of 0.15 and 1.25 μM .

HY-141584

ATSP-7041	MDM-2/p53	Cancer
ATSP-7041, a selective dual peptide inhibitor of MDM2 and MDMX, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers .

HY-P5910

Azurin p28 peptide	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P3508A

PNC-27 acetate	MDM-2/p53	Cancer
PNC-27 acetate, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 acetate is an anticancer peptide. PNC-27 acetate can be used in acute myeloid leukemia research .

HY-P3508

PNC-27	MDM-2/p53	Cancer
PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research .

HY-P5910A

Azurin p28 peptide TFA	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces apoptosis or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P10610

Peptide 234CM	MDM-2/p53	Cancer
Peptide 234CM is a peptide containing isoleucine at position 3, corresponding to the sequence of a point mutation in p53 codon 234. Peptide 234CM induces potent cytotoxic T cell (CTL) and antitumor immune responses against mutant p53 .

HY-P3528

GPR	Caspase Apoptosis	Neurological Disease
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting *caspase-3/p53* dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P10877

Bicyclic UK18	PAI-1	Cancer
Bicyclic UK18 is a competitive inhibitor for human urokinase-type plasminogen activator (uPA) with a K_i of 53 nM .

HY-W010913

(S)-2-((tert-Butoxycarbonyl)amino)-5-(3-tosylguanidino)pentanoic acid	Amino Acid Derivatives	Others
(S)-2-((tert-Butoxycarbonyl)amino)-5-(3-tosylguanidino)pentanoic acid is an arginine derivative .

HY-P1562

PUMA BH3	Bcl-2 Family	Cancer
PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM.

HY-P1562A

PUMA BH3 TFA	Bcl-2 Family	Cancer
PUMA BH3 TFA is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM .

HY-P3103

PINT-87aa	DNA/RNA Synthesis	Cancer
PINT-87aa, an 87-amino acid (aa) peptide, is encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT). PINT-87aa directly interacts with polymerase associated factor complex (PAF1c) and inhibits the transcriptional elongation of multiple oncogenes. PINT-87aa suppresses glioblastoma cell proliferation in vitro and in vivo .

HY-P3103A

PINT-87aa TFA	DNA/RNA Synthesis	Cancer
PINT-87aa TFA, an 87-amino acid (aa) peptide, is encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT). PINT-87aa TFA directly interacts with polymerase associated factor complex (PAF1c) and inhibits the transcriptional elongation of multiple oncogenes. PINT-87aa TFA suppresses glioblastoma cell proliferation in vitro and in vivo .

HY-P1948

Thioredoxin reductase peptide	Peptides	Inflammation/Immunology Cancer
Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research. Thioredoxin reductase acts as a reductant of disulfide-containing proteins and plays crucial role in cellular antioxidant defense .

HY-P1948A

Thioredoxin reductase peptide TFA	Peptides	Others
Thioredoxin reductase peptide TFA corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research. Thioredoxin reductase acts as a reductant of disulfide-containing proteins and plays crucial role in cellular antioxidant defense .

HY-P4157

FOXO4-DRI	MDM-2/p53 Apoptosis	Metabolic Disease
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and *p53. FOXO4-DRI is a senolytic peptide that induces apoptosis* of senescent cells .

HY-P4157A

FOXO4-DRI acetate	MDM-2/p53 Apoptosis	Metabolic Disease
FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and *p53. FOXO4-DRI acetate is a senolytic peptide that induces apoptosis* of senescent cells .

HY-N7491

Verticilide	Calcium Channel	Inflammation/Immunology
Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC₅₀ value of 4.2 μM (whereas inhibition against mouse ryanodine receptors was weak (IC₅₀=53.9 μM)) .

HY-P3509A

PNC-28 acetate	MDM-2/p53	Cancer
PNC-28 acetate is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 acetate can be used for pancreatic cancer research .

HY-P3509

PNC-28	MDM-2/p53	Cancer
PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research .

HY-P10589

Phomopsinamine A	Microtubule/Tubulin	Cancer
Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for tubulin polymerization with IC₅₀ of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC₅₀ =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC₅₀ =0.32 μM) .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species (ROS) Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

HY-P11212

Ac-RHKK(Ac)-AMC	Fluorescent Dye	Metabolic Disease Cancer
Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research .

Cat. No.	Product Name

HY-KE8008

T4 DNA Polymerase
T4 DNA polymerase has 5′→3′ DNA polymerase activity and can catalyze the synthesis of DNA along the 5′→3′ direction with the presence of templates and primers.

HY-KE7050

BsmB I
BsmB I is one of the endonucleases of Type IIs that recognize non-palindromic sequences and cut outside of the recognition sequence, and is commonly used in Golden Gate assembly. Isoschizomers: Esp3 I, BstGZ53 I, Esp16 I, Esp23 I.

HY-KE7052

BsmB I, ADCF
BsmB I, ADCF is animal derived component free, and has good redundancy of enzyme activity, which can easily cope with excessive substrate or difficult template enzyme cutting. Isoschizomers: Esp3 I, BstGZ53 I, Esp16 I, Esp23 I.

HY-KE8002

Bst DNA Polymerase, Full Length
Bst DNA Polymerase is derived from Bacillus stearothermophilus and has 5'→3' DNA polymerase activity and double-stranded specific 5'→3' exonuclease activity.

Cat. No.	Product Name	Target	Research Area

HY-P99128

Anti-Mouse CD8 beta Antibody (53-5.8)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse CD8 beta Antibody (53-5.8) is an anti-mouse CD8 beta IgG2a monoclonal antibody. Anti-Mouse CD8 beta Antibody (53-5.8) can deplete CD8 ⁺ T cells and enhance cytotoxicity. Anti-Mouse CD8 beta Antibody (53-5.8) can be used for research on immunology .

HY-P990820

Anti-Mouse TIM-4 Antibody (RMT4-53)	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Anti-Mouse TIM-4 Antibody (RMT4-53) is a rat-derived IgG2b κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-53) can block T cell immunoglobulin and mucin domain 4 (TIM-4). Anti-Mouse TIM-4 Antibody (RMT4-53) can inhibit the engulfment of apoptotic cells and T cell proliferation. Anti-Mouse TIM-4 Antibody (RMT4-53) can be used for the researches of cancer, immunology and metabolic disease, such as MC38 tumor and graft .

HY-P99129

Anti-Mouse CD8a Antibody (53-6.7) 2 Publications Verification	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice .

HY-P990123

Anti-Mouse ICOSL/CD275 Antibody (HK5.3)	Transmembrane Glycoprotein Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is an anti-mouse ICOSL/CD275 IgG2a monoclonal antibody. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can inhibit the adhesion between T cells and endothelial cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can reduce the expansion of tissue resident (TR) Treg cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can be used for researches on inflammation and infection conditions such as influenza virus infection and arthritis .

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces *p53* expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

HY-P990235

Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3)	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) contains the D265A mutation region. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can be used for researches of inflammation and infection.

HY-P990234

Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3)	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) contains the LALA-PG mutation region. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) can be used for researches of inflammation and infection.

Species:	Human (40) Virus (1) Rat (2) Mouse (5) Bovine (1) Cynomolgus (3)
Tag:	His (38) SUMO (2) Tag Free (7) Avi (11) TAT (1) GST (3) Fc (5)
Source:	HEK293 (24) Sf9 insect cells (3) P. pastoris (1) E. coli (24)

Cat. No.	Compare	Product Name	Species	Source

HY-P71703

	p53 Protein, Rat (His) Tp53; P53; Cellular tumor antigen p53; Tumor suppressor p53	Rat	E. coli
	The p53 protein acts as a tumor suppressor, regulates the cell cycle and induces growth arrest or apoptosis.It activates genes that inhibit cell division and trigger apoptosis by controlling the expression of various proteins.p53 Protein, Rat (His) is the recombinant rat-derived p53 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P72257

	Cellular tumor antigen P53/TP53, Human (His-SUMO) 1 Publications Verification BCC7; p53; p53 tumor suppressor; Phosphoprotein p5	Human	E. coli
	The cellular tumor antigen P53/TP53 is a tumor suppressor that can induce growth arrest or apoptosis in a variety of tumor types. It regulates the cell cycle by negatively controlling genes critical for division. Cellular tumor antigen P53/TP53, Human (His-SUMO) is the recombinant human-derived Cellular tumor antigen P53/TP53, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P76806

	CD53 Protein, Cynomolgus (HEK293, His) Leukocyte surface antigen CD53; Cell surface glycoprotein CD53	Cynomolgus	HEK293
	CD53 protein is an important member of the tetraspanin family and plays an important role in immune response, cell adhesion and signal transduction. Its research enhances understanding of cell membrane organization and function, with potential applications in immunology and cancer research. CD53 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD53 protein, expressed by HEK293 , with N-His labeled tag.

HY-P703091

	BRCA1 Protein, Human RNF53	Human	E. coli
	BRCA1 Protein, Human is the recombinant human-derived BRCA1, expressed by E. coli, with tag free labeled tag.

HY-P703417

	TRIm72 Protein, Human MG53	Human	E. coli
	TRIm72 Protein, Human is the recombinant human-derived TRIm72, expressed by E. coli , with tag Free labeled tag. ,

HY-P701428

	USP53 Protein, Human USP53; Inactive ubiquitin carboxyl-terminal hydrolase 53; Inactive ubiquitin-specific peptidase 53	Human	E. coli
	USP53 protein, a critical element in tight junctions, is essential for the survival of auditory hair cells and the maintenance of hearing function. Although lacking peptidase activity, USP53's importance is highlighted by its interaction with the TJP1:TJP2 heterodimer, suggesting nuanced involvement in the molecular architecture of tight junctions. This interaction emphasizes USP53's potential impact on cellular survival and auditory processes. USP53 Protein, Human is the recombinant human-derived USP53 protein, expressed by E. coli , with tag free.

HY-P701427

	USP53 Protein, Human (His, GST) USP53; Inactive ubiquitin carboxyl-terminal hydrolase 53; Inactive ubiquitin-specific peptidase 53	Human	E. coli
	USP53 protein, a critical element in tight junctions, is essential for the survival of auditory hair cells and the maintenance of hearing function. Although lacking peptidase activity, USP53's importance is highlighted by its interaction with the TJP1:TJP2 heterodimer, suggesting nuanced involvement in the molecular architecture of tight junctions. This interaction emphasizes USP53's potential impact on cellular survival and auditory processes. USP53 Protein, Human (His, GST) is the recombinant human-derived USP53 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.

HY-P75396

	CD53 Protein, Mouse (HEK293, His) Leukocyte surface antigen CD53; Cell surface glycoprotein CD53; CD53	Mouse	HEK293
	CD53 Protein plays a crucial role in efficient myofiber formation during muscle regeneration, specifically facilitating cell fusion. Additionally, CD53 is implicated in growth regulation in hematopoietic cells. Its interaction with SCIMP underscores its involvement in various cellular processes. CD53 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD53 protein, expressed by HEK293 , with N-His labeled tag.

HY-P76807

	CD53 Protein, Cynomolgus (HEK293, Fc) Leukocyte surface antigen CD53; Cell surface glycoprotein CD53	Cynomolgus	HEK293
	CD53 protein is an important member of the tetraspanin family and plays an important role in immune response, cell adhesion and signal transduction. Its research enhances understanding of cell membrane organization and function, with potential applications in immunology and cancer research. CD53 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD53 protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P70116

	Cornulin Protein, Human (His) rHuCornulin, His; Cornulin; 53 kDa Putative Calcium-Binding Protein; 53 kDa Squamous Epithelial-Induced Stress Protein; 58 kDa Heat Shock Protein; Squamous Epithelial Heat Shock Protein 53; Tumor-Related Protein; CRNN; C1orf10; DRC1; PDRC1; SEP53	Human	E. coli
	Cornulin protein is critical in cell dynamics, promoting proliferation and promoting G1/S cell cycle progression, inducing the key regulator CCND1. It actively participates in the NFKB1 and PI3K/AKT pathways and responds to pro-inflammatory cytokines. Cornulin Protein, Human (His) is the recombinant human-derived Cornulin protein, expressed by E. coli , with N-6*His labeled tag.

HY-P77778

	*HLA-A02:01&B2M&P53 WT(HMTEVVRRC) Monomer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77779

	*HLA-A02:01&B2M&P53 WT(HMTEVVRRC) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77780

	*HLA-A02:01-B2M&P53 WT(HMTEVVRRC) Tetramer Protein, Human (HMTEVVRRC, HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77775

	*HLA-A02:01&B2M&P53 R175H(HMTEVVRHC) Monomer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77777

	*HLA-A02:01&B2M&P53 R175H(HMTEVVRHC) Tetramer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77776

	*HLA-A02:01&B2M&P53 R175H(HMTEVVRHC) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P703418

	TRIM72 Protein, Human (His) MG53	Human	E. coli
	TRIM72 Protein, Human (His) is the recombinant human-derived TRIM72, expressed by E. coli , with His labeled tag. ,

HY-P76534

	p53R2 Protein, Human (His) Ribonucleoside-diphosphate reductase subunit M2 B; p53R2; RRM2B	Human	E. coli
	The p53R2 protein is essential for cell survival and operates in a p53/TP53-dependent manner to support DNA repair. It provides essential deoxyribonucleotides for DNA repair, particularly in G1 or G2 arrested cells, and contains an iron-tyrosyl radical center critical for catalysis. p53R2 Protein, Human (His) is the recombinant human-derived p53R2 protein, expressed by E. coli , with N-His labeled tag.

HY-P77461

	PANP/C12orf53 Protein, Human (HEK293, Fc) PILR alpha-associated neural protein; C12orf53; PANP; PIANP	Human	HEK293
	PANP/C12orf53 Protein acts as a neural tissue ligand for PILRA, indicating its potential role in immune regulation in this context. PANP/C12orf53 Protein, Human (HEK293, Fc) is the recombinant human-derived PANP/C12orf53 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74481

	UNC5B Protein, Human (HEK293, His) Netrin receptor UNC5B; p53RDL1; UNC5B; P53RDL1; UNC5H2	Human	HEK293
	UNC5B is an important netrin receptor that mediates axonal repulsion during nervous system development and binds to DCC to trigger signaling pathways. It negatively regulates vascular branching in angiogenesis, inducing tip cell filopodia retraction. UNC5B Protein, Human (HEK293, His) is the recombinant human-derived UNC5B protein, expressed by HEK293 , with C-His labeled tag.

HY-P74482

	UNC5B Protein, Human (HEK293, hFc) Netrin receptor UNC5B; p53RDL1; UNC5B; P53RDL1; UNC5H2	Human	HEK293
	UNC5B is an important netrin receptor that mediates axonal repulsion during nervous system development and binds to DCC to trigger signaling pathways. It negatively regulates vascular branching in angiogenesis, inducing tip cell filopodia retraction. UNC5B Protein, Human (HEK293, hFc) is the recombinant human-derived UNC5B protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76120

	UNC5B Protein, Rat (HEK293, Fc) Netrin receptor UNC5B; p53RDL1; UNC5B; P53RDL1; UNC5H2	Rat	HEK293
	UNC5B is a netrin-1-dependent receptor. It negatively regulates vascular branching during angiogenesis. In addition, UNC5B protects myelin and partially alleviates injury-induced neuropathic pain (NP). UNC5B is involved in the guidance of axons and the positive regulation of exogenous apoptosis signaling pathways without binding to netrin-1. UNC5B Protein, Rat (HEK293, Fc) is the recombinant rat-derived UNC5B protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705328

	*HLA-A02:01&B2M&p53(GLAPPQHLIRV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A*0201 & B2M & p53 (GLAPPQHLIRV)	Human	HEK293

HY-P705329

	*HLA-A02:01&B2M&p53(HMTEVVRHC) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A*0201 & B2M & p53 (HMTEVVRHC)	Human	HEK293

HY-P705331

	*HLA-A02:01&B2M&p53(RMPEAAPPV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A*0201 & B2M & p53 (RMPEAAPPV)	Human	HEK293

HY-P705363

	*HLA-A24:02&B2M&p53 Monomer(TYSPALNKMF) Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A*2402 & B2M & p53 (TYSPALNKMF)	Human	HEK293

HY-P704415

	*PE-Labeled HLA-A02:01&B2M&p53(G25-I308) Tetramer Protein, Human (HEK293, His-Avi)** HLA-A*0201 & B2M & p53 (HMTEVVRHC)	Human	HEK293

HY-P71134

	WARS Protein, Human (His) WARS also known as Tryptophanyl-tRNA synthetase; Interferon-induced protein 53.	Human	E. coli
	WARS includes isomer 1, isomer 2, T1-TrpRS and T2-TrpRS, and has aminoacylation activity, except T2-TrpRS. Unlike isoform 1, isoform 2, T1-TrpRS and T2-TrpRS, exhibit vasostatic activity. WARS Protein, Human (His) is the recombinant human-derived WARS protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74632

	PIG3 Protein, Human (His) Quinone oxidoreductase PIG3; TP53I3; PIG3	Human	E. coli
	PIG3 is a key player in cellular processes, functioning as an enzyme that catalyzes NADPH-dependent quinone reduction. It exhibits moderate enzymatic activity towards β-naphthoquinone, with the para -quinone isomer (1,2-β-naphthoquinone) compared to the para -isomer (1,4-β-naphthoquinone). Obvious preference. PIG3 Protein, Human (His) is the recombinant human-derived PIG3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P73540

	WARS Protein, Human (sf9, His) Tryptophan--tRNA ligase, cytoplasmic; IFP53; TrpRS; WARS1; WARS	Human	Sf9 insect cells
	WARS includes isomer 1, isomer 2, T1-TrpRS and T2-TrpRS, and has aminoacylation activity, except T2-TrpRS. Unlike isoform 1, isoform 2, T1-TrpRS and T2-TrpRS, exhibit vasostatic activity. WARS Protein, Human (sf9, His) is the recombinant human-derived WARS protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P70417

	GAMT Protein, Human (His) rHuGuanidinoacetate N-methyltransferase/GAMT, His; Guanidinoacetate N-methyltransferase; GAMT; PIG2; TP53I2	Human	E. coli
	GAMT protein uses S-adenosylmethionine as a methyl donor to catalyze the conversion of guanidinoacetic acid into creatine, playing a key role in cell metabolism. This enzyme activity is essential for the biosynthesis of creatine, a compound necessary for cellular energy storage and transport. GAMT Protein, Human (His) is the recombinant human-derived GAMT protein, expressed by E. coli , with N-6His, C-6His labeled tag.

HY-P71919

	TIGAR Protein, Human (TAT) 6-bisphosphatase TIGAR; C12ORF5; chromosome 12 open reading frame 5; FR2BP; Fructose-2,6-bisphosphatase TIGAR; Fructose-2,6-bisphosphate 2-phosphatase; Probable fructose 2,6 bisphosphatase TIGAR; Probable fructose-2; tigar; TIGAR_HUMAN; TP53 induced glycolysis and apoptosis regulator; TP53 induced glycolysis regulatory phosphatase; TP53-induced glycolysis and apoptosis regulator; Transactivated by NS3TP2 protein	Human	E. coli
	TIGAR is a protein that helps cells survive stress by regulating glycolysis and promoting cell survival. It reduces reactive oxygen species (ROS) levels and protects against oxidative damage. TIGAR also plays a role in promoting tissue regeneration and has neuroprotective effects. In cancer cells, TIGAR promotes DNA repair and is involved in tumor progression. TIGAR Protein, Human (TAT) is the recombinant human-derived TIGAR protein, expressed by E. coli , with C-TAT labeled tag.

HY-P76537

	PDRG1 Protein, Human (His) p53 and DNA damage-regulated protein 1; PDRG1; C20orf126; PDRG	Human	E. coli
	As a component of the PAQosome complex, the PDRG1 protein may play a role in chaperone-mediated protein folding. PAQosome is composed of multiple protein complexes, including PDRG1, and coordinates the biogenesis of multiple protein complexes. PDRG1 Protein, Human (His) is the recombinant human-derived PDRG1 protein, expressed by E. coli , with N-His labeled tag.

HY-P703779

	IGFBP2 Protein, Cynomolgus (HEK293, His) IBP-2; IGFBP-2; BP2; AI255832; mIGFBP-2; IGFBP2; IGF-BP53	Cynomolgus	HEK293
	IGFBP2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP2 protein, expressed by HEK293, with C-His tag.

HY-P71799

	HE/Hemagglutinin-esterase Protein, Bovine (P.pastoris, His) HE; 2b; Hemagglutinin-esterase; HE protein; EC 3.1.1.53; E3 glycoprotein	Bovine	P. pastoris
	Hemagglutinin esterase is a structural protein with a short spike that is critical for viral attachment and initiation of infection. It exhibits receptor binding and destructive activities, de-O-acetylating possible viral receptor determinants. HE/Hemagglutinin-esterase Protein, Bovine (P.pastoris, His) is the recombinant bovine-derived HE/Hemagglutinin-esterase, expressed by P. pastoris, with N-His labeled tag. The total length of HE/Hemagglutinin-esterase Protein, Bovine (P.pastoris, His) is 406 a.a..

HY-P74846

	IGFBP-2 Protein, Mouse (HEK293, His) IBP-2; Insulin-like growth factor binding protein 2; IGFBP2; IGF-BP53	Mouse	HEK293
	IGFBP-2 protein, a member of the IGF-binding protein family, inhibits IGF-mediated growth and developmental rates. It can extend the half-life of IGF and exhibit dual functions by inhibiting or stimulating the growth-promoting effect of IGF in cell culture. IGFBP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGFBP-2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74847

	IGFBP-2 Protein, Mouse (HEK293, Fc) IBP-2; Insulin-like growth factor binding protein 2; IGFBP2; IGF-BP53	Mouse	HEK293
	IGFBP-2 protein, a member of the IGF-binding protein family, inhibits IGF-mediated growth and developmental rates. It can extend the half-life of IGF and exhibit dual functions by inhibiting or stimulating the growth-promoting effect of IGF in cell culture. IGFBP-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77821

	PLD4 Protein, Mouse (HEK293, His) 5'-3' exonuclease PLD4; Choline phosphatase 4; Phospholipase D4; PLD 4	Mouse	HEK293
	PLD4 Protein, with 5'->3' DNA exonuclease activity, efficiently digests single-stranded DNA (ssDNA). It crucially regulates inflammatory cytokine responses by degrading nucleic acids, reducing ssDNA concentrations activating TLR9. Additionally, PLD4 actively participates in the phagocytosis process of activated microglia, emphasizing its role in immune responses. PLD4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLD4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78019

	PLD4 Protein, Human (HEK293, His) 5'-3' exonuclease PLD4; Choline phosphatase 4; Phospholipase D4; PLD 4	Human	HEK293
	PLD4 Protein, a phospholipase, plays a crucial role in immune responses and inflammation. Dysregulation of PLD4 Protein has been associated with autoimmune disorders and inflammatory diseases. Targeting PLD4 Protein may provide potential therapeutic interventions in these conditions by modulating immune responses, suppressing inflammation, and managing related disorders. PLD4 Protein, Human (HEK293, His) is the recombinant human-derived PLD4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72107

	BRCC36 Protein, Human (His-SUMO) BRCA1-A complex subunit BRCC36; BRCA1/BRCA2 containing complex subunit 3; BRCA1/BRCA2 containing complex subunit 36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; Brcc3; BRCC3_HUMAN; BRCC36; BRISC complex subunit BRCC36; C6.1A ; Chromosome X open reading frame 53; CXorf53; Lys-63-specific deubiquitinase BRCC36; OTTHUMP00000061450	Human	E. coli
	BRCC36 is a metalloprotease that selectively cleaves "Lys-63" linked polyubiquitin chains, especially histones H2A and H2AX in the BRCA1-A complex during the DNA damage response. As the catalytic subunit of the BRISC complex, it also targets “Lys-63”-linked ubiquitin in various substrates, affecting mitotic spindle assembly and interferon signaling. BRCC36 Protein, Human (His-SUMO) is the recombinant human-derived BRCC36 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P75349

	CHEK2 Protein, Human (sf9, GST) Serine/threonine-protein kinase Chk2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Human	Sf9 insect cells
	The CHEK2 protein is a serine/threonine protein kinase that critically coordinates checkpoint-mediated cell cycle arrest, DNA repair activation, and apoptosis in response to DNA double-strand breaks. Activated CHEK2 phosphorylates CDC25A, CDC25B, and CDC25C, inhibiting their phosphatase activities and preventing the CDK-cyclin complex from activating cell cycle progression. CHEK2 Protein, Human (sf9, GST) is the recombinant human-derived CHEK2 protein, expressed by Sf9 insect cells , with GST labeled tag.

HY-P75348

	CHEK2 Protein, Mouse (sf9, His-GST) Serine/threonine-protein kinase Chk2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Mouse	Sf9 insect cells
	CHEK2 is a serine/threonine protein kinase that coordinates cellular responses to DNA double-strand breaks by activating cell cycle arrest, DNA repair, and apoptosis. It phosphorylates effectors and inhibits CDC25A, CDC25B, and CDC25C, thereby enhancing CDK cyclin inhibition and cell cycle arrest. CHEK2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CHEK2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P704891

	SNCA Protein, Human (A53T) Alpha-Synuclein; Non-A Beta Component of AD Amyloid; Non-A4 Component of Amyloid Precursor; NACP; SNCA; NACP; PARK1	Human	E. coli

HY-P704890

	SNCA Protein, Human (A53T, His) Alpha-Synuclein; Non-A Beta Component of AD Amyloid; Non-A4 Component of Amyloid Precursor; NACP; SNCA; NACP; PARK1	Human	E. coli

HY-P703359

	PPP1CB Protein, Human (His) Serine/threonine-protein phosphatase PP1-beta catalytic subunit; PP-1B; PPP1CD; EC:3.1.3.16; EC:3.1.3.53	Human	E. coli
	PPP1CB Protein, Human (His) is the recombinant human-derived PPP1CB, expressed by E. coli , with N-6*His labeled tag.

HY-P70358

	Galectin-7/LGALS7 Protein, Human rHuGalectin-7; Galectin-7; Gal-7; HKL-14; PI7; p53-Induced Gene 1 Protein; LGALS7; PIG1; LGALS7B	Human	E. coli
	Galectin-7 (LGALS7), a protein with potential involvement in cell-cell and/or cell-matrix interactions crucial for normal growth control, serves as a pro-apoptotic factor. It functions intracellularly, playing a role upstream of JNK activation and cytochrome c release, thus contributing to apoptotic pathways. Galectin-7 exists as a monomer, highlighting its individual unit structure. Galectin-7/LGALS7 Protein, Human is the recombinant human-derived Galectin-7/LGALS7 protein, expressed by E. coli , with tag free.

HY-P75097

	HA/Hemagglutinin Protein, H3N2 (AGG53108, HEK293, His) Influenza A H3N2 (A/swine/Thailand/CU-P53/2012) Hemagglutinin / HA Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis.HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions.HA/Hemagglutinin Protein, H3N2 (AGG53108, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P704895

	SNCA Pre-formed Fibrils Protein, Human (A53T, His) Alpha-Synuclein; Non-A Beta Component of AD Amyloid; Non-A4 Component of Amyloid Precursor; NACP; SNCA; NACP; PARK1	Human	E. coli

HY-P700080AF

	Animal-Free Galectin-7/LGALS7 Protein, Human (His) Galectin-7; Galectin-7; Gal-7; HKL-14; PI7; p53-Induced Gene 1 Protein; LGALS7; PIG1; LGALS7B	Human	E. coli
	Galectin-7 (LGALS7), a protein with potential involvement in cell-cell and/or cell-matrix interactions crucial for normal growth control, serves as a pro-apoptotic factor. It functions intracellularly, playing a role upstream of JNK activation and cytochrome c release, thus contributing to apoptotic pathways. Galectin-7 exists as a monomer, highlighting its individual unit structure. Animal-Free Galectin-7/LGALS7 Protein, Human (His) is the recombinant human-derived animal-FreeGalectin-7/LGALS7 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P703577

	PDE7A1 Protein, Human High affinity 3',5'-cyclic-AMP phosphodiesterase 7A; HCP1; TM22; cAMP-specific phosphodiesterase 7A; PDE7A; Homo sapiens; Human; Hydrolase; 3.1.4.53	Human	E. coli
	PDE7A1 Protein, Human is the recombinant human-derived PDE7A1, expressed by E. coli , with tag Free labeled tag. ,

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HY-P80001

	53BP1 Antibody (YA649) 1 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	53BP1 Antibody (YA649) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 53BP1.

HY-P80938

	p53 Antibody TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
	p53 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to p53.

HY-P80843

	Phospho-p53 (Ser37) Antibody 1 Publications Verification TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF	Human, Mouse, Rat
	Phospho-p53 (Ser37) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-p53 (Ser37).

HY-P80844

	Phospho-p53 (Ser6) Antibody (YA166) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, IHC-P, IP	Human
	Phospho-p53 (Ser6) Antibody (YA166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p53 (Ser6).

HY-P86652

	Phospho-p53(S15) Antibody (YA6344) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF	Human
	Phospho-p53(S15) Antibody (YA6344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p53(S15).

HY-P86435

	53BP1 Antibody (YA6127) TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1	WB, ICC/IF, IP, ELISA	Human
	53BP1 Antibody (YA6127) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 53BP1.

HY-P84521

	53BP1 Antibody (YA4218) p202; 53BP1	IHC-P, FC, ELISA	Human
	53BP1 Antibody (YA4218) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to 53BP1.

HY-P86169

	p53 Antibody (YA5861) Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; p53; p53 tumor suppressor; P53_HUMAN; Phosphoprotein p53; Tp53; Transformation related protein 53; TRP53; tumor antigen p55; Tumor protein 53; Tumor protein p53; Tumor suppressor p53;	WB, IHC-P, ICC/IF, IP, ELISA	Human
	p53 Antibody (YA5861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53.

HY-P83948

	p53 Antibody (YA3645) LFS1, TRP53, TP53	WB, IHC-P, ELISA	Human
	p53 Antibody (YA3645) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p53.

HY-P81370

	CD53 Antibody (YA1115) CD53; MOX44; TSPAN25; Leukocyte surface antigen CD53; Cell surface glycoprotein CD53; Tetraspanin-25; Tspan-25; CD53	IHC-P	Human
	CD53 Antibody (YA1115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD53.

HY-P80532

	Acetyl-p53 (Lys370) Antibody (YA640) P53; BCC7; LFS1; TRP53	WB, ICC/IF, IP	Human, Mouse, Rat
	Acetyl-p53 (Lys370) Antibody (YA640) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Acetyl-p53 (Lys370).

HY-P82831

	TP53BP2 Antibody (YA2576) 53BP2; ASPP2; p53BP2; PPP1R13A; Tp53bp2	WB, IHC-P, ICC/IF	Human
	TP53BP2 Antibody (YA2576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TP53BP2.

HY-P80573

	BRCA1 Antibody BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Rat
	BRCA1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to BRCA1.

HY-P86277

	TP53BP2 Antibod (YA5969) TP53BP2; ASPP2; BBP; Apoptosis-stimulating of p53 protein 2 ; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2;	WB, IHC-P, ICC/IF, ICC	Human
	TP53BP2 Antibody (YA5969) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TP53BP2.

HY-P82939

	ACTL6A Antibody (YA2684) ACTL6A; BAF53; BAF53A; INO80K; Actin-like protein 6A; 53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K	WB, ICC/IF, IP	Human
	ACTL6A Antibody (YA2684) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ACTL6A.

HY-P80257

	p53 Antibody (YA250) 1 Publications Verification	WB, IHC-P, ICC/IF	Human
	p53 Antibody (YA250) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53.

HY-P81863

	Tryptophan tRNA Ligase Antibody (YA1608) Gamma2; hWRS; IFI53; IFP53; TrpRS; WARS; WRS	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Tryptophan tRNA Ligase Antibody (YA1608) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tryptophan tRNA Ligase.

HY-P80259

	p53 DINP1 Antibody (YA249)	WB, ICC/IF	Human, Mouse, Rat
	p53 DINP1 Antibody (YA249) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53 DINP1.

HY-P84670

	C17ORF53 Antibody (YA4367)	ICC/IF, FC, ELISA	Human
	C17ORF53 Antibody (YA4367) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to C17ORF53.

HY-P84289

	BRCA1 Antibody (YA3986) IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53	IHC-P, ELISA	Human
	BRCA1 Antibody (YA3986) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BRCA1.

HY-P80258

	p53 (acetyl K382) Antibody (YA251)	WB, ICC/IF, IHC-P	Human
	p53 (acetyl K382) Antibody (YA251) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53 (acetyl K382).

HY-P80260

	p53 (acetyl K370)Antibody (YA248)	WB, ICC/IF, IP	Human
	p53 (acetyl K370)Antibody (YA248) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53 (acetyl K370).

HY-P80472

	Phospho-p53 (Ser392) Antibody (YA167) 1 Publications Verification	WB, IHC-P, IP	Human, Mouse
	Phospho-p53 (Ser392) Antibody (YA167) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p53 (Ser392).

HY-P81495

	p73 Antibody (YA1240) TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein	IHC-P	Human
	p73 Antibody (YA1240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p73.

HY-P82183

	CDK5RAP3 Antibody (YA1928) C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114	WB, IHC-P, IP	Human, Mouse
	CDK5RAP3 Antibody (YA1928) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK5RAP3.

HY-P84157

	CD53 Antibody (YA3854) MOX44; TSPAN25	WB, IHC-P, FC, ELISA	Human
	CD53 Antibody (YA3854) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD53.

HY-P87349

	PAG608 Antibody (YA7032) FLJ12296 antibody; FLJ31683 antibody; MGC10613 antibody; OTTHUMP00000211906 antibody; OTTHUMP00000211907 antibody; p53 activated gene 608 antibody; p53 inducible zinc finger protein antibody; p53 target zinc finger protein antibody; p53-activated gene 608 protein antibody; PAG 608 antibody	WB	Human, Rat
	PAG608 Antibody (YA7032) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PAG608.

HY-P82098

	RBBP4 Antibody (YA1843) NURF55; RBAP48; lin-53	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
	RBBP4 Antibody (YA1843) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RBBP4.

HY-P82553

	BRCC36 Antibody (YA2298) C6.1A; BRCC36; CXorf53	WB, IP	Human, Mouse, Rat
	BRCC36 Antibody (YA2298) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRCC36.

HY-P85272

	MDMX Antibody (YA4964) MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4	WB, IHC-P, ICC/IF, ELISA	Human
	MDMX Antibody (YA4964) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MDMX.

HY-P84796

	p63 Antibody (YA4493) TP63,AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)	IHC-P, FC, ELISA	Human
	p63 Antibody (YA4493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P83399

	Killin Antibody (YA3144) killin; p53-regulated DNA replication inhibitor; CWS4; KILLIN	WB	Human, Mouse, Rat
	Killin Antibody (YA3144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Killin.

HY-P84041

	SAA1 Antibody (YA3738) SAA; PIG4; SAA2; TP53I4	IHC-P, FC, ELISA	Human
	SAA1 Antibody (YA3738) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SAA1.

HY-P85481

	WDR79 Antibody (YA5173) WRAP53; TCAB1; WDR79; Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53	WB	Human, Mouse, Rat
	WDR79 Antibody (YA5173) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to WDR79.

HY-P81626

	Nesprin3 Antibody (YA1371) KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341	WB	Human
	Nesprin3 Antibody (YA1371) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nesprin3.

HY-P86329

	PUMA Antibody (YA6021) BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PUMA Antibody (YA6021) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PUMA.

HY-P85926

	PGP9.5 Antibody (YA5618) Epididymis luminal protein 117; Epididymis secretory protein Li 53; HEL 117; HEL S 53; NDGOA; Neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; Park 5; PARK5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal hydrolase; Ubiquitin C terminal hydrolase L1; Ubiquitin carboxyl terminal esterase L1; Ubiquitin carboxyl terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; Ubiquitin thiolesterase; Ubiquitin thiolesterase L1; UCH-L1; UCHL1; UCHL1_HUMAN	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	PGP9.5 Antibody (YA5618) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGP9.5.

HY-P82704

	MAD1L1 Antibody (YA2449) hMAD1; HsMAD1; MAD1; MAD1L1; PIG9; TP53I9; TXBP181	WB	Human, Mouse, Rat
	MAD1L1 Antibody (YA2449) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAD1L1.

HY-P83887

	ALDH1A1 Antibody (YA3584) ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e	WB, IHC-P, FC, ELISA	Human
	ALDH1A1 Antibody (YA3584) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ALDH1A1.

HY-P84038

	PGP9.5 Antibody (YA3735) NDGOA; PARK5; PGP95; SPG79; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	PGP9.5 Antibody (YA3735) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PGP9.5.

HY-P81996

	Prostaglandin E Synthase Antibody (YA1741) PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1	WB	Human, Mouse, Rat
	Prostaglandin E Synthase Antibody (YA1741) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prostaglandin E Synthase.

HY-P85877

	Lyn Antibody (YA5569) Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Lyn Antibody (YA5569) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lyn.

HY-P83705

	MDM2 Antibody (YA3442) ACTFS antibody; Double minute 2 protein antibody; E3 ubiquitin-protein ligase Mdm2 antibody; Hdm 2 antibody; Hdm2 antibody; HDMX antibody; MDM 2 antibody; MDM2 antibody; MDM2 oncogene E3 ubiquitin protein ligase antibody; Mdm2 p53 E3 ubiquitin protein ligase homolog antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; MDM2_HUMAN antibody; MDM2BP antibody; Mouse Double Minute 2 antibody; MTBP antibody; Murine Double Minute Chromosome 2 antibody; Oncoprotein Mdm2 antibody; p53 Binding Protein Mdm2 antibody; p53-binding protein Mdm2 antibody; Ubiquitin protein ligase E3 Mdm2 antibody; Ubiquitin protein ligase E3 Mdm2 antibody	WB, IHC-P, ICC/IF	Human, Monkey
	MDM2 Antibody (YA3442) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MDM2.

HY-P86219

	MDM2 Antibody (YA5911) MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MDM2 Antibody (YA5911) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MDM2.

HY-P80747

	Lyn Antibody (YA707) LYN; JTK8; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn	WB	Human
	Lyn Antibody (YA707) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lyn.

HY-P85265

	Lyn Antibody (YA4957) LYN; JTK8; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn	WB, ELISA	Human
	Lyn Antibody (YA4957) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Lyn.

HY-P86494

	Chk2 Antibody (YA6186) CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Chk2 Antibody (YA6186) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Chk2.

HY-P80799

	Phospho-Chk2 (Thr68) Antibody 1 Publications Verification CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Phospho-Chk2 (Thr68) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-Chk2 (Thr68).

HY-P81260

	beta 2 Microglobulin Antibody (YA934) B2MG; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin form pI 5.3; CDABP0092; Hdcma22p	ELISA	Human
	beta 2 Microglobulin Antibody (YA934) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to beta 2 Microglobulin.

HY-P81260A

	beta 2 Microglobulin Antibody (YA935) B2MG; Beta 2 microglobin; Beta 2 microglobulin; Beta-2-microglobulin form pI 5.3; CDABP0092; Hdcma22p	WB, IP	Human, Mouse, Rat
	beta 2 Microglobulin Antibody (YA935) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta 2 Microglobulin.

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Cat. No.	Product Name		Classification

HY-159493

BI2536-PEG2-Halo		Azide
BI2536-PEG2-Halo is a bifunctional molecule containing a ligand for Halo tag and a Polo-like kinase 1 (PLK1) inhibitor BI-2536 (HY-50698). BI2536-PEG2-Halo inhibits the proliferation of 293T cells with Halo-p53R273H(FL)-mCherry tag (IC₅₀=23 nM), exhibits selective toxicity against p53 mutant cancer cells .

HY-W001538

S-Propargylcysteine SPRC		Alkynes
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H₂S-releasing compound. S-Propargylcysteine reduces Ca ²⁺ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .

HY-154255

5-(3-Azidopropyl)uridine		Azide
5-(3-Azidopropyl)uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis . 5-(3-Azidopropyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152787

5-(3-Azidopropyl)cytidine		Azide
5-(3-Azidopropyl)cytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities . 5-(3-Azidopropyl)cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159132

CAIX/CAXII-IN-2		Azide
CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with K_i values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research .

HY-149926

Cathepsin Inhibitor 3		Alkynes
Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [ ¹⁸F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research . Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-154255

5-(3-Azidopropyl)uridine		Nucleoside Analogs Uridine
5-(3-Azidopropyl)uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis . 5-(3-Azidopropyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152787

5-(3-Azidopropyl)cytidine		Nucleoside Analogs Cytidine
5-(3-Azidopropyl)cytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities . 5-(3-Azidopropyl)cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-174511

Human TP53 mRNA		mRNA
Human TP53 mRNA encodes the human tumor protein p53 (TP53) protein, a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. TP53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.

HY-RS15846

WRAP53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
WRAP53 Human Pre-designed siRNA Set A contains three designed siRNAs for WRAP53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03658

DDX53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DDX53 Human Pre-designed siRNA Set A contains three designed siRNAs for DDX53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26380

Cd53 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cd53 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd53 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11256

PRSS53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRSS53 Human Pre-designed siRNA Set A contains three designed siRNAs for PRSS53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19881

Cd53 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cd53 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd53 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20514

Usp53 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Usp53 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Usp53 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14913

Tp53 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tp53 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp53 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15564

USP53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
USP53 Human Pre-designed siRNA Set A contains three designed siRNAs for USP53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15698

VPS53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VPS53 Human Pre-designed siRNA Set A contains three designed siRNAs for VPS53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15102

Trp53 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Trp53 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trp53 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02254

CD53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CD53 Human Pre-designed siRNA Set A contains three designed siRNAs for CD53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14912

TP53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27023

Usp53 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Usp53 Rat Pre-designed siRNA Set A contains three designed siRNAs for Usp53 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14922

TP53RK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53RK Human Pre-designed siRNA Set A contains three designed siRNAs for TP53RK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04717

FAM53B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FAM53B Human Pre-designed siRNA Set A contains three designed siRNAs for FAM53B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14915

TP53BP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01705

C19orf53 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
C19orf53 Human Pre-designed siRNA Set A contains three designed siRNAs for C19orf53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26028

Tp53i3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tp53i3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp53i3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14920

TP53INP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53INP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53INP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14917

TP53I11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53I11 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28596

Tp53inp1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tp53inp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp53inp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14916

TP53BP2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53BP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53BP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14918

TP53I13 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53I13 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14919

TP53I3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53I3 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14921

TP53INP2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53INP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53INP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14914

TP53AIP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TP53AIP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53AIP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-132611A

Golodirsen sodium SRP-4053 sodium		Antisense Oligonucleotides
Golodirsen sodium is a phosphorodiamidate morpholino oligomer (PMO) that specifically targets exon 53 of dystrophin pre-mRNA. Golodirsen sodium can be used for the research of Duchenne muscular dystrophy (DMD) .

HY-132611

Golodirsen SRP-4053		Antisense Oligonucleotides
Golodirsen (SRP-4053) is a phosphorodiamidate morpholino oligomer (PMO) that specifically targets exon 53 of dystrophin pre-mRNA. Golodirsen can be used for the research of Duchenne muscular dystrophy (DMD) .

HY-132586

Viltolarsen NS-065/NCNP-01		Antisense Oligonucleotides
Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen has the potential for Duchenne muscular dystrophy (DMD) research .

HY-132586A

Viltolarsen sodium NS-065/NCNP-01 sodium		Antisense Oligonucleotides
Viltolarsen (NS-065/NCNP-01) sodium is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen sodium binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen sodium has the potential for Duchenne muscular dystrophy (DMD) research .

HY-RS00187

ACP2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ACP2 Human Pre-designed siRNA Set A contains three designed siRNAs for ACP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-132595A

Teprasiran sodium QPI-1002 sodium		siRNAs siRNA drugs
Teprasiran sodium is a small interfering RNA that temporarily inhibits *p53*-mediated cell death that underlies acute kidney injury (AKI) .

HY-132595

Teprasiran QPI-1002		siRNAs siRNA drugs
Teprasiran (QPI-1002) is a small interfering RNA that temporarily inhibits *p53*-mediated cell death that underlies acute kidney injury (AKI) .

HY-152543

5-[3-[(Trifluoroacetyl)amino]propyl]uridine		Nucleoside Analogs Uridine
5-[3-[(Trifluoroacetyl)amino]propyl]uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis .

HY-174777

Human BAK1 mRNA		mRNA
Human BAK1 mRNA encodes the human BCL2 antagonist/killer 1 (BAK1) protein, a member of the BCL2 protein family. BAK1 localizes to mitochondria, and functions to induce apoptosis. It also interacts with the tumor suppressor P53 after exposure to cell stress.