ASPP2 Antibody (YA5969)

ASPP2 Antibody (YA5969) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ASPP2. It can be applicated for WB, IHC-P, ICC/IF, ICC assays, in the background of human.

ASPP2 is a key regulator that plays a central role in apoptosis and cell growth control through its interactions with proteins such as TP53. It modulates TP53 by enhancing its DNA binding and transactivation function on the promoters of proapoptotic genes. Additionally, ASPP2 inhibits NAE1's ability to conjugate NEDD8 to CUL1, thereby reducing NAE1-mediated apoptosis induction. It also impedes cell cycle progression at the G2/M phase. Notably, its apoptosis-stimulating activity is suppressed by its interaction with DDX42.

Q13625

Observed band size: 124 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human

WB: 1:1000-5000; IHC: 1:100-300; ICC/ICC/IF: 1:100-300

WB, IHC-P, ICC/IF, ICC

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG