2. Immunology/Inflammation Apoptosis NF-κB
  3. Interleukin Related MDM-2/p53 NF-κB
  4. Astegolimab

Astegolimab  (Synonyms: MSTT 1041A; RG 6149)

Cat. No.: HY-P99444 Purity: 99.00%
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Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research.

For research use only. We do not sell to patients.

CAS No. : 2173054-79-8

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Based on 2 publication(s) in Google Scholar

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Astegolimab Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research[1][2][3].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Human
IC50 & Target[1]

ST2

 

In Vitro

Astegolimab could block the effect of CM-induced neutrophil extracellular trap (NET) formation in HL-60 cells[2].
Astegolimab (10 μM) blocks the effect of exogenous IL33 on cardiomyocyte (AC16) senescence[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Astegolimab Related Antibodies

Western Blot Analysis[3]

Cell Line: AC16 cells treated with IL33
Concentration: 10 μM
Incubation Time:
Result: Reduced p53 expression.
Mitigated IL33-upregulated SASP factors such as IL1α, IL6 and MCP1.
Mitigated IL33-increased p-p65/p65 ratio.
Clinical Trial
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

144.98 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Astegolimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized ST2/IL1RL1 Protein, Human can bind Astegolimab. The EC50 for this effect is 28.29 ng/mL.
  • Loaded ST2/IL1RL1 Protein, Human (310a.a, HEK293, His, HY-P70615) on AHC2 biosensor, can bind Astegolimab with an affinity constant of 2.022E-10 M as determined in BLI assay.
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (232 KB) SDS-PAGE (110 KB) SEC-HPLC (465 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Astegolimab Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Astegolimab2173054-79-8MSTT 1041A RG 6149RG6149RG 6149RG-6149Interleukin RelatedMDM-2/p53NF-κBILNuclear factor-κBNuclear factor-kappaBIgG2monoclonal antibodyIL-33ST2chronic obstructive pulmonary diseaseCOPDInhibitorinhibitorinhibit

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