2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. GW 848687X

GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain.

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GW 848687X

GW 848687X Chemical Structure

CAS No. : 612831-24-0

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Based on 1 publication(s) in Google Scholar

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Description

GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain[1].

In Vivo

GW 848687X (30 mg/kg; po; b.i.d, 5 d) exhibits antihyperalgesic activity in an FCA-induced inflammatory joint pain model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FCA induced joint pain model of inflammatory pain[1]
Dosage: 30mg/kg
Administration: po; twice daily for 5 days
Result: Completely reversed pain sensation in rats and had anti-pain effects.
Molecular Weight

441.85

Formula

C24H18ClF2NO3
CAS No.
SMILES

O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW 848687X612831-24-0Prostaglandin ReceptorInhibitorinhibitorinhibit

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