p53 Antibody (YA3645)

p53 Antibody (YA3645) is a mouse-derived and non-conjugated IgG1 antibody, targeting to p53. It can be applicated for WB, IHC-P, ELISA assays, in the background of human.

p53 protein functions as a tumor suppressor in numerous tumor types, exerting its effects through the induction of growth arrest or apoptosis depending on the physiological conditions and cell type. In the realm of cell cycle regulation, p53 acts as a trans-activator that negatively regulates cell division by overseeing a set of genes crucial for this process, including an inhibitor of cyclin-dependent kinases. Apoptosis induction by p53 is thought to occur through the stimulation of BAX and FAS antigen expression or repression of Bcl-2 expression. The multifaceted role of p53 underscores its significance in orchestrating cellular responses to maintain genomic integrity and counteract aberrant cell proliferation.

P04637

Predicted band size: 44 kDa; Observed band size: 53 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; IHC: 1/200-1/1000; ELISA: 1/10000

WB, IHC-P, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human p53 expressed in E. Coli.